IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Christelle THIBAULT-CARPENTIER

• Engineers & Technicians

  Violaine ALUNNI

  Marie CERCIAT

  Bernard JOST

  Matthieu JUNG

  Romain KAISER

  Céline KEIME

  Stéphanie LE GRAS

  Damien PLASSARD

  Serge VICAIRE

  Tao YE

• Statistician Engineer

  Doulaye DEMBELE

Technology platforms

Genomeast

Largely opened to the scientific community and one of the partners of the national network France-Génomique, this platform is dedicated to large-scale gene analysis. It provides comprehensive services for two complementary technologies : DNA microarrays and deep sequencing, up to bioinformatic data analysis. Our main activities consist in studying gene expression, identifying genetic mutations and polymorphisms, mapping protein binding sites on chromatin or identifying small regulating RNA.

• Genomeast Platform official website

• Current projects

• Collaborations

• Prizes/Awards

• News

  • New web tool to filter/extract your variants of interest (DNA-seq)
  • Introduction to NGS data analysis – 28-29th of September and 2nd of October 2017 (Training)
  • NGS symposium 2016 - 4-5 July 2016 – Illkirch, France
  • Our new Hiseq 4000 sequencer is now up and ready
  • Double certification: ISO 9001:2008 - NFX 50-900
  • Introduction to NGS data analysis - 10th and 11th of March 2016 (Training)
  • Introduction to NGS data analysis - 29th and 30th of September 2016 (Training)
  • Introduction to NGS data analysis - 24th and 25th of September 2015 (Training)
  • Bioinformatics School AVIESAN IFB - 27th of September to 2nd of October 2015. (Training)
  • 2nd 2015 call for the program High-Throughput sequencing and rare diseases (Call for projects)
  • Melanoma : a better understanding for a better healing

• Publications

  • Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.

    Piccand J(1), Vagne C(1), Blot F(1), Meunier A(1), Beucher A(1), Strasser P(1), Lund ML(2), Ghimire S(1), Nivlet L(1), Lapp C(1), Petersen N(2), Engelstoft MS(2), Thibault-Carpentier C(1), Keime C(1), Correa SJ(1), Schreiber V(1), Molina N(1), Schwartz TW(2), De Arcangelis A(3), Gradwohl G(4).

    Mol Metab Nov 2019

  • Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor.

    Carvalho K(1), Faivre E(1), Pietrowski MJ(2), Marques X(3), Gomez-Murcia V(1), Deleau A(1), Huin V(1), Hansen JN(2), Kozlov S(2), Danis C(1)(4), Temido-Ferreira M(5), Coelho JE(5), Meriaux C(1), Eddarkaoui S(1), Gras SL(6), Dumoulin M(7), Cellai L(1); NeuroCEB Brain Bank, Landrieu I(4), Chern Y(8), Hamdane M(1), Buee L(1), Boutillier AL(9), Levi S(3), Halle A(2)(10), Lopes LV(5), Blum D(1).

    Brain Oct. 10, 2019

  • Novel IQCE variations confirm its role in postaxial polydactyly and cause ciliary defect phenotype in zebrafish.

    Estrada-Cuzcano A(1), Etard C(2), Delvallee C(1), Stoetzel C(1), Schaefer E(1)(3), Scheidecker S(1)(4), Geoffroy V(1), Schneider A(1), Studer F(5), Mattioli F(6), Chennen K(1)(7), Sigaudy S(8), Plassard D(9), Poch O(7), Piton A(4)(6), Strahle U(2), Muller J(1)(4), Dollfus H(1)(3)(5).

    Hum Mutat Sept. 24, 2019

  • Publisher Correction: An actin-based viscoplastic lock ensures progressive body-axis elongation.

    Lardennois A(1), Pasti G(2), Ferraro T(1), Llense F(1), Mahou P(3), Pontabry J(2)(4), Rodriguez D(2), Kim S(2), Ono S(5), Beaurepaire E(3), Gally C(2), Labouesse M(6)(7).

    Nature Sept. 6, 2019

  • In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.

    Rossitto M(1), Ollivier M(1)(2), Dejardin S(1), Pruvost A(3), Brun C(4), Marchive C(1), Nguyen AL(3), Ghettas A(3), Keime C(5), de Massy B(4), Poulat F(1), Philibert P(1)(6), Boizet-Bonhoure B(1).

    Commun Biol Aug. 13, 2019

  • Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm.

    Aldea D(1), Subirana L(1), Keime C(2), Meister L(1), Maeso I(3), Marcellini S(4), Gomez-Skarmeta JL(3), Bertrand S(5), Escriva H(6).

    Nat Ecol Evol Aug 2019

  • Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium.

    Raliou M(1), Dembele D(2), Duvel A(3), Bolifraud P(1), Aubert J(4), Mary-Huard T(4), Rocha D(5), Piumi F(1), Mockly S(1), Heppelmann M(6), Dieuzy-Labaye I(7), Zieger P(8), G E Smith D(9), Schuberth HJ(3), Sheldon IM(10), Sandra O(1).

    PLoS One Aug. 2, 2019

  • Deep RNA-Seq reveals miRNome differences in mammary tissue of lactating Holstein and Montbeliarde cows.

    Billa PA(1), Faulconnier Y(1), Ye T(2), Chervet M(3), Le Provost F(4), Pires JAA(1), Leroux C(5)(6).

    BMC Genomics July 30, 2019

  • Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

    Vogerl K(1), Ong N(1), Senger J(2), Herp D(2), Schmidtkunz K(2), Marek M(3), Muller M(1), Bartel K(1), Shaik TB(3), Porter NJ(4), Robaa D(5), Christianson DW(4), Romier C(3), Sippl W(5), Jung M(2), Bracher F(1).

    J Med Chem Feb. 14, 2019

  • RNA profiling of human testicular cells identifies syntenic lncRNAs associated with spermatogenesis.

    Rolland AD(1), Evrard B(1), Darde TA(1)(2), Le Beguec C(1), Le Bras Y(2), Bensalah K(3), Lavoue S(4), Jost B(5), Primig M(1), Dejucq-Rainsford N(1), Chalmel F(1), Jegou B(1).

    Hum Reprod July 8, 2019

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