IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Engineers & Technicians

  Violaine ALUNNI

  Marie CERCIAT

  Bernard JOST

  Matthieu JUNG

  Romain KAISER

  Céline KEIME

  Stéphanie LE GRAS

  Damien PLASSARD

  Serge VICAIRE

  Tao YE

• Statistician Engineer

  Doulaye DEMBELE

• Christelle THIBAULT-CARPENTIER

Technology platforms

Genomeast

Largely opened to the scientific community and one of the partners of the national network France-Génomique, this platform is dedicated to large-scale gene analysis. It provides comprehensive services for two complementary technologies : DNA microarrays and deep sequencing, up to bioinformatic data analysis. Our main activities consist in studying gene expression, identifying genetic mutations and polymorphisms, mapping protein binding sites on chromatin or identifying small regulating RNA.

• Genomeast Platform official website

• Current projects

• Collaborations

• Prizes/Awards

• News

  • Introduction to NGS data analysis – 28-29th of September and 2nd of October 2017 (Training)
  • New web tool to filter/extract your variants of interest (DNA-seq)
  • NGS symposium 2016 - 4-5 July 2016 – Illkirch, France
  • Our new Hiseq 4000 sequencer is now up and ready
  • Double certification: ISO 9001:2008 - NFX 50-900
  • Introduction to NGS data analysis - 10th and 11th of March 2016 (Training)
  • Introduction to NGS data analysis - 24th and 25th of September 2015 (Training)
  • Introduction to NGS data analysis - 29th and 30th of September 2016 (Training)
  • Bioinformatics School AVIESAN IFB - 27th of September to 2nd of October 2015. (Training)
  • 2nd 2015 call for the program High-Throughput sequencing and rare diseases (Call for projects)
  • Melanoma : a better understanding for a better healing

• Publications

  • Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm.

    Aldea D(1), Subirana L(1), Keime C(2), Meister L(1), Maeso I(3), Marcellini S(4), Gomez-Skarmeta JL(3), Bertrand S(5), Escriva H(6).

    Nat Ecol Evol Aug 2019

  • Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium.

    Raliou M(1), Dembele D(2), Duvel A(3), Bolifraud P(1), Aubert J(4), Mary-Huard T(4), Rocha D(5), Piumi F(1), Mockly S(1), Heppelmann M(6), Dieuzy-Labaye I(7), Zieger P(8), G E Smith D(9), Schuberth HJ(3), Sheldon IM(10), Sandra O(1).

    PLoS One Aug. 2, 2019

  • Deep RNA-Seq reveals miRNome differences in mammary tissue of lactating Holstein and Montbeliarde cows.

    Billa PA(1), Faulconnier Y(1), Ye T(2), Chervet M(3), Le Provost F(4), Pires JAA(1), Leroux C(5)(6).

    BMC Genomics July 30, 2019

  • Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

    Vogerl K(1), Ong N(1), Senger J(2), Herp D(2), Schmidtkunz K(2), Marek M(3), Muller M(1), Bartel K(1), Shaik TB(3), Porter NJ(4), Robaa D(5), Christianson DW(4), Romier C(3), Sippl W(5), Jung M(2), Bracher F(1).

    J Med Chem Feb. 14, 2019

  • RNA profiling of human testicular cells identifies syntenic lncRNAs associated with spermatogenesis.

    Rolland AD(1), Evrard B(1), Darde TA(1)(2), Le Beguec C(1), Le Bras Y(2), Bensalah K(3), Lavoue S(4), Jost B(5), Primig M(1), Dejucq-Rainsford N(1), Chalmel F(1), Jegou B(1).

    Hum Reprod July 8, 2019

  • Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures.

    Merienne N(1), Meunier C(2), Schneider A(3), Seguin J(3), Nair SS(4), Rocher AB(5), Le Gras S(6), Keime C(6), Faull R(7), Pellerin L(8), Chatton JY(9), Neri C(4), Merienne K(3), Deglon N(10).

    Cell Rep Feb. 26, 2019

  • Identification and expression of microRNAs in european eels Anguilla anguilla from two natural sites with different pollution levels.

    Bertucci A(1), Pierron F(2), Ye T(3), Gonzalez P(2), Couture P(4), Baudrimont M(2).

    Environ Pollut Jul 2019

  • Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.

    Dieudonne Y(1), Gies V(2), Guffroy A(3), Keime C(4), Bird AK(5), Liesveld J(6), Barnas JL(5), Poindron V(1), Douiri N(7), Soulas-Sprauel P(8), Martin T(3), Meffre E(9), Anolik JH(5), Korganow AS(10).

    J Autoimmun August 2019

  • Co-translational assembly of mammalian nuclear multisubunit complexes.

    Kamenova I(1)(2)(3)(4), Mukherjee P(1)(2)(3)(4), Conic S(1)(2)(3)(4), Mueller F(5), El-Saafin F(1)(2)(3)(4), Bardot P(1)(2)(3)(4), Garnier JM(1)(2)(3)(4), Dembele D(1)(2)(3)(4), Capponi S(6), Timmers HTM(6), Vincent SD(1)(2)(3)(4), Tora L(7)(8)(9)(10).

    Nat Commun April 15, 2019

  • Microglia Express Mu Opioid Receptor: Insights From Transcriptomics and Fluorescent Reporter Mice.

    Maduna T(1)(2)(3)(4), Audouard E(1)(2)(3)(4), Dembele D(1)(2)(3)(4), Mouzaoui N(1)(2)(3)(4)(5), Reiss D(1)(2)(3)(4), Massotte D(6), Gaveriaux-Ruff C(1)(2)(3)(4)(5).

    Front Psychiatry Jan. 4, 2019

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