IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Christelle THIBAULT-CARPENTIER

• Engineers & Technicians

  Violaine ALUNNI

  Marie CERCIAT

  Bernard JOST

  Matthieu JUNG

  Romain KAISER

  Céline KEIME

  Stéphanie LE GRAS

  Damien PLASSARD

  Serge VICAIRE

  Tao YE

• Statistician Engineer

  Doulaye DEMBELE

Technology platforms

Genomeast

Largely opened to the scientific community and one of the partners of the national network France-Génomique, this platform is dedicated to large-scale gene analysis. It provides comprehensive services for two complementary technologies : DNA microarrays and deep sequencing, up to bioinformatic data analysis. Our main activities consist in studying gene expression, identifying genetic mutations and polymorphisms, mapping protein binding sites on chromatin or identifying small regulating RNA.

• Genomeast Platform official website

• Current projects

• Collaborations

• Prizes/Awards

• News

  • New web tool to filter/extract your variants of interest (DNA-seq)
  • Introduction to NGS data analysis – 28-29th of September and 2nd of October 2017 (Training)
  • NGS symposium 2016 - 4-5 July 2016 – Illkirch, France
  • Our new Hiseq 4000 sequencer is now up and ready
  • Double certification: ISO 9001:2008 - NFX 50-900
  • Introduction to NGS data analysis - 10th and 11th of March 2016 (Training)
  • Introduction to NGS data analysis - 29th and 30th of September 2016 (Training)
  • Introduction to NGS data analysis - 24th and 25th of September 2015 (Training)
  • Bioinformatics School AVIESAN IFB - 27th of September to 2nd of October 2015. (Training)
  • 2nd 2015 call for the program High-Throughput sequencing and rare diseases (Call for projects)
  • Melanoma : a better understanding for a better healing

• Publications

  • Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (1): specific signatures of stromal, glandular and luminal epithelial cells.

    Chankeaw W, Lignier S, Richard C, Ntallaris T, Raliou M, Guo Y, Plassard D, Bevilacqua C, Sandra O, Andersson G, Humblot P, Charpigny G

    BMC Genomics June 18, 2021

  • Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (2): impacts of post-partum negative energy balance on stromal, glandular and luminal epithelial cells.

    Chankeaw W, Lignier S, Richard C, Ntallaris T, Raliou M, Guo Y, Plassard D, Bevilacqua C, Sandra O, Andersson G, Humblot P, Charpigny G

    BMC Genomics June 18, 2021

  • Photoreceptor cKO of OTX2 enhances OTX2 intercellular transfer in the retina and causes photophobia.

    Pensieri P, Mantilleri A, Plassard D, Furukawa T, Moya KL, Prochiantz A, Lamonerie T

    eNeuro Sept. 2, 2021

  • Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells.

    Zhang J, Le Gras S, Pouxvielh K, Faure F, Fallone L, Kern N, Moreews M, Mathieu AL, Schneider R, Marliac Q, Jung M, Berton A, Hayek S, Vidalain PO, Marçais A, Dodard G, Dejean A, Brossay L, Ghavi-Helm Y, Walzer T

    Nat Commun Sept. 14, 2021

  • Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells.

    Grunddal KV, Tonack S, Egerod KL, Thompson JJ, Petersen N, Engelstoft MS, Vagne C, Keime C, Gradwohl G, Offermanns S, Schwartz TW

    Mol Metab April 5, 2021

  • Nutrigenomic analyses reveal miRNAs and mRNAs affected by feed restriction in the mammary gland of midlactation dairy cows.

    Billa PA, Faulconnier Y, Ye T, Bourdon C, Pires JAA, Leroux C

    PLoS One 2021

  • Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.

    Zorro Shahidian L, Haas M, Le Gras S, Nitsch S, Mourão A, Geerlof A, Margueron R, Michaelis J, Daujat S, Schneider R

    EMBO Rep March 3, 2021

  • Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process.

    Mimouni NEH, Paiva I, Barbotin AL, Timzoura FE, Plassard D, Le Gras S, Ternier G, Pigny P, Catteau-Jonard S, Simon V, Prevot V, Boutillier AL, Giacobini P

    Cell Metab March 2, 2021

  • Radiosensitizing Pancreatic Cancer with PARP Inhibitor and Gemcitabine: An In Vivo and a Whole-Transcriptome Analysis after Proton or Photon Irradiation.

    Waissi W, Nicol A, Jung M, Rousseau M, Jarnet D, Noel G, Burckel H

    Cancers (Basel) Jan. 30, 2021

  • Temozolomide-Induced RNA Interactome Uncovers Novel LncRNA Regulatory Loops in Glioblastoma.

    Fritah S, Muller A, Jiang W, Mitra R, Sarmini M, Dieterle M, Golebiewska A, Ye T, Van Dyck E, Herold-Mende C, Zhao Z, Azuaje F, Niclou SP

    Cancers (Basel) Sept. 10, 2020

  See all publications =>

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