IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Christelle THIBAULT-CARPENTIER

• Engineers & Technicians

  Violaine ALUNNI

  Marie CERCIAT

  Bernard JOST

  Matthieu JUNG

  Romain KAISER

  Céline KEIME

  Stéphanie LE GRAS

  Damien PLASSARD

  Serge VICAIRE

  Tao YE

• Statistician Engineer

  Doulaye DEMBELE

Technology platforms

Genomeast

Largely opened to the scientific community and one of the partners of the national network France-Génomique, this platform is dedicated to large-scale gene analysis. It provides comprehensive services for two complementary technologies : DNA microarrays and deep sequencing, up to bioinformatic data analysis. Our main activities consist in studying gene expression, identifying genetic mutations and polymorphisms, mapping protein binding sites on chromatin or identifying small regulating RNA.

• Genomeast Platform official website

• Current projects

• Collaborations

• Prizes/Awards

• News

  • New web tool to filter/extract your variants of interest (DNA-seq)
  • Introduction to NGS data analysis – 28-29th of September and 2nd of October 2017 (Training)
  • NGS symposium 2016 - 4-5 July 2016 – Illkirch, France
  • Our new Hiseq 4000 sequencer is now up and ready
  • Double certification: ISO 9001:2008 - NFX 50-900
  • Introduction to NGS data analysis - 10th and 11th of March 2016 (Training)
  • Introduction to NGS data analysis - 29th and 30th of September 2016 (Training)
  • Introduction to NGS data analysis - 24th and 25th of September 2015 (Training)
  • Bioinformatics School AVIESAN IFB - 27th of September to 2nd of October 2015. (Training)
  • 2nd 2015 call for the program High-Throughput sequencing and rare diseases (Call for projects)
  • Melanoma : a better understanding for a better healing

• Publications

  • TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.

    Yu C, Cvetesic N, Hisler V, Gupta K, Ye T, Gazdag E, Negroni L, Hajkova P, Berger I, Lenhard B, Müller F, Vincent SD, Tora L

    Nat Commun Dec. 22, 2020

  • µgreen-db: a reference database for the 23S rRNA gene of eukaryotic plastids and cyanobacteria.

    Djemiel C, Plassard D, Terrat S, Crouzet O, Sauze J, Mondy S, Nowak V, Wingate L, Ogée J, Maron PA

    Sci Rep April 3, 2020

  • An Integrated Analysis of miRNA and Gene Expression Changes in Response to an Obesogenic Diet to Explore the Impact of Transgenerational Supplementation with Omega 3 Fatty Acids.

    Corral-Jara KF, Cantini L, Poupin N, Ye T, Rigaudière JP, De Saint Vincent S, Pinel A, Morio B, Capel F

    Nutrients Dec. 17, 2020

  • Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.

    Laurent AP, Siret A, Ignacimouttou C, Panchal K, Diop M, Jenni S, Tsai YC, Roos-Weil D, Aid Z, Prade N, Lagarde S, Plassard D, Pierron G, Daudigeos E, Lecluse Y, Droin N, Bornhauser BC, Cheung LC, Crispino JD, Gaudry M, Bernard OA, Macintyre E, Barin Bonnigal C, Kotecha RS, Geoerger B, Ballerini P, Bourquin JP, Delabesse E, Mercher T, Malinge S

    Clin Cancer Res July 1, 2020

  • Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3.

    Burton A, Brochard V, Galan C, Ruiz-Morales ER, Rovira Q, Rodriguez-Terrones D, Kruse K, Le Gras S, Udayakumar VS, Chin HG, Eid A, Liu X, Wang C, Gao S, Pradhan S, Vaquerizas JM, Beaujean N, Jenuwein T, Torres-Padilla ME

    Nat Cell Biol Jul 2020

  • Meiosis Occurs Normally in the Fetal Ovary of Mice Lacking All Retinoic Acid Receptors

    Nadège Vernet (1) , Diana Condrea (1) , Chloé Mayere (2) , Betty Féret (1) , Muriel Klopfenstein (1) , William Magnant (1) , Violaine Alunni (3) , Marius Telentin (1) (4) , Sirine Souali-Crespo (1) , Serge Nef (2) , Manuel Mark (1) (4), Norbert B Ghyselinck (1)

    Science Advances 2020 May 22 2020

  • Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma.

    Rabé M(1), Dumont S(1)(2), Álvarez-Arenas A(3), Janati H(4), Belmonte-Beitia J(3), Calvo GF(3), Thibault-Carpentier C(5), Séry Q(1)(6), Chauvin C(1), Joalland N(1), Briand F(1), Blandin S(7), Scotet E(1), Pecqueur C(1), Clairambault J(4), Oliver L(1)(8), Perez-Garcia V(3), Nadaradjane A(1)(6), Cartron PF(1)(6), Gratas C(9)(10), Vallette FM(11)(12).

    Cell Death Dis Jan. 6, 2020

  • An actin-based viscoplastic lock ensures progressive body-axis elongation

    Alicia Lardennois 1 , Gabriella Pásti 2 , Teresa Ferraro 1 , Flora Llense 1 , Pierre Mahou 3 , Julien Pontabry 2 4 , David Rodriguez 2 , Samantha Kim 2 , Shoichiro Ono 5 , Emmanuel Beaurepaire 3 , Christelle Gally 2 , Michel Labouesse 6 7

    Nature 2019

  • In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.

    Rossitto M(1), Ollivier M(1)(2), Déjardin S(1), Pruvost A(3), Brun C(4), Marchive C(1), Nguyen AL(3), Ghettas A(3), Keime C(5), de Massy B(4), Poulat F(1), Philibert P(1)(6), Boizet-Bonhoure B(7).

    Commun Biol Aug. 13, 2019

  • Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3.

    Florian RT(1), Kraft F(2), Leitao E(1), Kaya S(1), Klebe S(3), Magnin E(4), van Rootselaar AF(5), Buratti J(6), Kuhnel T(1), Schroder C(1), Giesselmann S(2), Tschernoster N(7), Altmueller J(7), Lamiral A(4), Keren B(6), Nava C(6)(8), Bouteiller D(8), Forlani S(8), Jornea L(8), Kubica R(1), Ye T(9), Plassard D(9), Jost B(9), Meyer V(10), Deleuze JF(10), Delpu Y(11), Avarello MDM(11), Vijfhuizen LS(12), Rudolf G(9)(13), Hirsch E(13), Kroes T(14), Reif PS(15)(16), Rosenow F(15)(16), Ganos C(17), Vidailhet M(8)(18), Thivard L(18), Mathieu A(19), Bourgeron T(19), Kurth I(2), Rafehi H(20)(21)(22), Steenpass L(1), Horsthemke B(1); FAME consortium, LeGuern E(6)(8), Klein KM(15)(16)(23), Labauge P(24), Bennett MF(20)(21)(22), Bahlo M(20)(21), Gecz J(14)(25), Corbett MA(14), Tijssen MAJ(26), van den Maagdenberg AMJM(12)(27), Depienne C(28)(29)(30).

    Nat Commun Oct. 29, 2019

  See all publications =>

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