Homeobox genes and neuronal identity specification

Le 06 mai 2022 à 11h00 Séminaire

Webinar connection

The enormous diversity of cell types in any animal model system is defined by neuron type-specific gene batteries that endow distinct cells with distinct anatomical and functional properties. Based on our own work in C. elegans as well as recent gene expression studies in vertebrates and flies, I propose that the diversity of neuronal cell types can be reduced to a simpler descriptor, the combinatorial expression of a specific class of transcription factors, encoded by homeobox genes. Functional studies in multiple animal model systems have corroborated the importance of homeobox genes in specifying neuronal identity. Recent unpublished work from my laboratory also shows that apart from controlling neuron-type specific gene batteries, a specific homeobox gene subfamily also control pan-neuronal identity features. I propose that the preponderance of homeobox genes in neuronal identity control is a reflection of an evolutionary trajectory in which an ancestral neuron type was specified by an ancestral homeobox genes and that this functional linkage then duplicated and diversified to generate distinct cell types in an evolving nervous system.

Development & Stem Cells department