Reconstitution of Artificial Transport Vesicles in Cells

Le 11 septembre 2025 à 10h00 Séminaire

Through molecular biological approaches, many proteins and lipids involved in organelle functions have been identified. However, the functions of organelles are still not fully understood. To address this, we are employing a novel synthetic cell biology approach. Artificial organelles are reconstituted from proteins and lipids in vitro and subsequently introduced into living cells, where their behavior can be analyzed to gain new insights into organelle functions and to create hybrid cells containing artificial organelles (Koike and Jahn, 2017, PNAS).In this presentation, I will talk about our recent work on the construction of artificial transport vesicles that are capable of delivering cargo specifically to designated target sites (Koike and Jahn, 2019, Nature Commun.; Koike and Jahn, 2024, Nature Commun.).