Christophe ROMIER

Publications

• 2021

  • Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

    • Martin Marek
    • Elizabeth Ramos-Morales
    • Gisele F A Picchi-Constante
    • Theresa Bayer
    • Carina Norström
    • Daniel Herp
    • Policarpo A Sales-Junior
    • Eloise P Guerra-Slompo
    • Kristin Hausmann
    • Alokta Chakrabarti
    • Tajith B Shaik
    • Annika Merz
    • Edouard Troesch
    • Karin Schmidtkunz
    • Samuel Goldenberg
    • Raymond J Pierce
    • Marina M Mourão
    • Manfred Jung
    • Johan Schultz
    • Wolfgang Sippl
    • ...

    Cell Reports ; Volume: 37

    HALDOI

  • The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination

    • Elizabeth Ramos Morales
    • Efil Bayam
    • Jordi del Pozo Rodriguez
    • Thalia Salinas-Giegé
    • Martin Marek
    • Peggy Tilly
    • Philippe Wolff
    • Edouard Troesch
    • Eric Ennifar
    • Laurence Drouard
    • Juliette Godin
    • Christophe Romier

    Nucleic Acids Research ; Volume: 49 ; Page: 6529-6548

    HALDOI

  • Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 (smHDAC8) Inhibitors

    • Conrad V. Simoben
    • Ehab Ghazy
    • Patrick Zeyen
    • Salma Darwish
    • Matthias Schmidt
    • Christophe Romier
    • Dina Robaa
    • Wolfgang Sippl

    Molecules ; Volume: 26

    HALDOI

  • Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation

    • Sébastien Coassolo
    • Guillaume Davidson
    • Luc Negroni
    • Giovanni Gambi
    • Sylvain Daujat
    • Christophe Romier
    • Irwin Davidson

    Nature Communications ; Volume: 12

    HALDOI

  • Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity

    • Hany S. Ibrahim
    • Mohamed Abdelsalam
    • Yanira Zeyn
    • Mathes Zessin
    • Al-Hassan Mustafa
    • Marten A. Fischer
    • Patrik Zeyen
    • Ping Sun
    • Emre F. Bulbul
    • Anita Vecchio
    • Frank Erdmann
    • Matthias Schmidt
    • Dina Robaa
    • Cyril Barinka
    • Christophe Romier
    • Mike Schutkowski
    • Oliver H. Kramer
    • Wolfgang Sippl

    International Journal of Molecular Sciences ; Volume: 23 ; Page: 369

    HALDOI

• 2020

  • Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

    • Ehab Ghazy
    • Patrik Zeyen
    • Daniel Herp
    • Martin Hügle
    • Karin Schmidtkunz
    • Frank Erdmann
    • Dina Robaa
    • Matthias Schmidt
    • Elizabeth Morales
    • Christophe Romier
    • Stefan Günther
    • Manfred Jung
    • Wolfgang Sippl

    European Journal of Medicinal Chemistry ; Volume: 200 ; Page: 112338

    HALDOI

• 2019

  • Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors

    • Dmitrii V. Kalinin
    • Sunit K. Jana
    • Maxim Pfafenrot
    • Alokta Chakrabarti
    • Jelena Melesina
    • Tajith B. Shaik
    • Julien Lancelot
    • Raymond J. Pierce
    • Wolfgang Sippl
    • Christophe Romier
    • Manfred Jung
    • Ralph Holl

    ChemMedChem ; Volume: 15 ; Page: 571-584

    HALDOI

  • One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

    • Matthes Zessin
    • Zsófia Kutil
    • Marat Meleshin
    • Zora Nováková
    • Ehab Ghazy
    • Diana Kalbas
    • Martin Marek
    • Christophe Romier
    • Wolfgang Sippl
    • Cyril Bařinka
    • Mike Schutkowski

    Biochemistry ; Volume: 58 ; Page: 4777-4789

    HALDOI

  • Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni ( Sm Sirt2)

    • Daria Monaldi
    • Dante Rotili
    • Julien Lancelot
    • Martin Marek
    • Nathalie Wössner
    • Alessia Lucidi
    • Daniela Tomaselli
    • Elizabeth Ramos-Morales
    • Christophe Romier
    • Raymond J. Pierce
    • Antonello Mai
    • Manfred Jung

    Journal of Medicinal Chemistry ; Volume: 62 ; Page: 8733-8759

    HALDOI

  • Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

    • Katharina Vögerl
    • Nghia Ong
    • Johanna Senger
    • Daniel Herp
    • Karin Schmidtkunz
    • Martin Marek
    • Martin Müller
    • Karin Bartel
    • Tajith Shaik
    • Nicholas Porter
    • Dina Robaa
    • David W. Christianson
    • Christophe Romier
    • Wolfgang Sippl
    • Manfred Jung
    • Franz Bracher

    Journal of Medicinal Chemistry ; Volume: 62 ; Page: 1138-1166

    HALDOI