Jean CAVARELLI

Publications

• 2022

  • Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach

    • Giulia Iannelli
    • Ciro Milite
    • Nils Marechal
    • Vincent Cura
    • Luc Bonnefond
    • Nathalie Troffer-Charlier
    • Alessandra Feoli
    • Donatella Rescigno
    • Yalong Wang
    • Alessandra Cipriano
    • Monica Viviano
    • Mark Bedford
    • Jean Cavarelli
    • Sabrina Castellano
    • Gianluca Sbardella

    Journal of Medicinal Chemistry ; Volume: 65 ; Page: 11574-11606

    HAL DOI

• 2021

  • Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase

    • Vincent Cura
    • Jean Cavarelli

    Life ; Volume: 11 ; Page: 1263

    HAL DOI

• 2020

  • FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts

    • Thomas Di Mattia
    • Arthur Martinet
    • Souade Ikhlef
    • Alastair G Mcewen
    • Yves Nominé
    • Corinne Wendling
    • Pierre Poussin‐courmontagne
    • Laetitia Voilquin
    • Pascal Eberling
    • Frank Ruffenach
    • Jean Cavarelli
    • John Slee
    • Timothy P Levine
    • Guillaume Drin
    • Catherine Tomasetto
    • Fabien Alpy

    EMBO Journal ; Volume: 39

    HAL DOI

  • Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation

    • Emmanuel Salomon
    • Marjorie Schmitt
    • Elisabeth Mouray
    • Alastair G Mcewen
    • Lotfi Bounaadja
    • Morgan Torchy
    • Pierre Poussin-Courmontagne
    • Sarah Alavi
    • Céline Tarnus
    • Jean Cavarelli
    • Isabelle Florent
    • Sebastien Albrecht

    Bioorganic Chemistry ; Volume: 98 ; Page: 103750

    HAL DOI

• 2018

  • Role of the SMN complex and the methylosome in selenoprotein mRNP assembly and translation

    • Anne-Sophie Gribling-Burrer
    • Hassan Hayek
    • Vincent Cura
    • Martine Barkats
    • Jean Cavarelli
    • Séverine Massenet
    • Franck Martin
    • Gilbert Eriani
    • Christine Allmang

    HAL

  • Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

    • Ludovic Halby
    • Nils Marechal
    • Dany Pechalrieu
    • Vincent Cura
    • Don-Marc Franchini
    • Céline Faux
    • Frédéric Alby
    • Nathalie Troffer-Charlier
    • Srikanth Kudithipudi
    • Albert Jeltsch
    • Wahiba Aouadi
    • Etienne Decroly
    • Jean-Claude Guillemot
    • Patrick Page
    • Clotilde Ferroud
    • Luc Bonnefond
    • Dominique Guianvarc'H
    • Jean Cavarelli
    • Paola Arimondo

    Philosophical Transactions of the Royal Society B: Biological Sciences ; Volume: 373 ; Page: 20170072

    HAL DOI

• 2017

  • SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation

    • Anne-Sophie Gribling-Burrer
    • Michael Leichter
    • Laurence Wurth
    • Alexandra Huttin
    • Florence Schlotter
    • Nathalie Troffer-Charlier
    • Vincent Cura
    • Martine Barkats
    • Jean Cavarelli
    • Séverine Massenet
    • Christine Allmang

    Nucleic Acids Research ; Volume: 45 ; Page: 5399-5413

    HAL DOI

  • Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis

    • G Peng
    • A Mcewen
    • V Olieric
    • Céline Schmitt
    • Sébastien Albrecht
    • Jean Cavarelli
    • Celine Tarnus

    Proteins ; Volume: 85 ; Page: 1413-1421

    HAL DOI

  • Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1

    • Matthijs van Haren
    • Nils Marechal
    • Nathalie Troffer-Charlier
    • Agostino Cianciulli
    • Gianluca Sbardella
    • Jean Cavarelli
    • Nathaniel Martin

    Proceedings of the National Academy of Sciences of the United States of America ; Volume: 114 ; Page: 3625-3630

    HAL DOI

  • Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors

    • Vincent Cura
    • N Marechal
    • N Troffer-Charlier
    • Jean-Marc Strub
    • M van Haren
    • Nathaniel I. Martin
    • Sarah Cianferani
    • Luc Bonnefond
    • Jean Cavarelli

    FEBS Journal ; Volume: 284 ; Page: 77-96

    HAL DOI