Stabilité de la chromatine et mobilité de l'ADN
Chefs d'équipe : Valerie LAMOUR , Marc RUFF
Département : Biologie structurale intégrative
Structure-fonction des complexes impliqués dans le cycle de réplication du VIH, conception de médicaments
Structure-fonction des complexes impliqués dans le cycle de réplication du VIH, conception de médicaments
RESPONSABLE DE SOUS-GROUPE
Équipes
Membres
Chercheur(euse)s
Doctorant(e)s
Ingénieur(eure)s
Technicien(ne)s
Publications
2019
A Molecular Tool Targeting the Base‐Flipping Activity of Human UHRF1
- Liliyana Zaayter
- Mattia Mori
- Tanveer Ahmad
- Waseem Ashraf
- Christian Boudier
- Vasyl Kilin
- Krishna Gavvala
- Ludovic Richert
- Sylvia Eiler
- Marc Ruff
- Maurizio Botta
- Christian Bronner
- Marc Mousli
- Yves Mély
Chemistry - A European Journal ; Volume: 25 ; Page: 13363-13375
HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates
- Srinivasa Reddy Bonam
- Marc Ruff
- Sylviane Muller
Cells ; Volume: 8 ; Page: 849
Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase
- Eric Mauro
- Paul Lesbats
- Delphine Lapaillerie
- Stéphane Chaignepain
- Benoit Maillot
- Oyindamola Oladosu
- Xavier Robert
- Francesca Fiorini
- Bruno Kieffer
- Serge Bouaziz
- Patrice Gouet
- Marc Ruff
- Vincent Parissi
Nucleic Acids Research ; Volume: 47 ; Page: 3607-3618
Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design
- Nicolas Lévy
- Jean-Michel Bruneau
- Erwann Le Rouzic
- Damien Bonnard
- Frédéric Le Strat
- Audrey Caravano
- Francis Chevreuil
- Julien Barbion
- Sophie Chasset
- Benoit Ledoussal
- François Moreau
- Marc Ruff
Journal of Medicinal Chemistry ; Volume: 62 ; Page: 4742-4754
Structures and Functions of the HIV-1 Pre-Integration Complexes
- Julien Batisse
- Eduardo Bruch
- Nicolas Lévy
- Patrice Gouet
- Stéphane Emiliani
- Vincent Parissi
- Marc Ruff
Biophysical Journal ; Volume: 116 ; Page: 62a
2018
Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain
- Claire Bedez
- Christophe Lotz
- Claire Batisse
- Arnaud Vanden Broeck
- Roland Stote
- Eduardo Howard
- Karine Pradeau Aubreton
- Marc Ruff
- Valerie Lamour
Scientific Reports ; Volume: 8
Genetic Flexibility of the NKNK Motif in HIV-1 Integrases Allows Its Involvement in Multiple Functions During Infection
- Marine Kanja
- Pierre Cappy
- Guillermo Blanco-Rodriguez
- Nicolas Levy
- Oyindamola Oladosu
- Sylvie Schmidt
- Romain Gasser
- Paola Rossolillo
- Christiane Moog
- Marc Ruff
- Francesca Di Nunzio
- Matteo Negroni
- Daniela Lener-Ory
Synthetic Biology eJournal
Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration
- Damien Bonnard
- Erwann Le Rouzic
- Sylvia Eiler
- Céline Amadori
- Igor Orlov
- Jean-Michel Bruneau
- Julie Brias
- Julien Barbion
- Francis Chevreuil
- Daniele Spehner
- Sophie Chasset
- Benoit Ledoussal
- François Moreau
- Ali Saib
- Bruno P. Klaholz
- Stéphane Emiliani
- Marc Ruff
- Alessia Zamborlini
- Richard Benarous
Journal of Biological Chemistry ; Volume: 293 ; Page: 6172-6186
Unstable Protein Purification Through the Formation of Stable Complexes
- Sylvia Eiler
- Nicolas Lévy
- Benoit Maillot
- Julien Batisse
- Karine Pradeau Aubreton
- Oyindamola Oladosu
- Marc Ruff
Methods in Molecular Biology ; Page: 315-328
Toward High Resolution Structures of the HIV-1 In/LEDGF/DNA Complex
- Julien Batisse
- Eduardo Bruch
- Nicolas Lévy
- Benoit Maillot
- Sylvia Eiler
- Oyindamola Oladosu
- Marc Ruff
Biophysical Journal ; Volume: 114 ; Page: 218a