Christophe ROMIER

Publications

• 2018

  • Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

    • Bertrand Lecointre
    • Remy Narozny
    • Maria Teresa Borrello
    • Johanna Senger
    • Alokta Chakrabarti
    • Manfred Jung
    • Martin Marek
    • Christophe Romier
    • Jelena Melesina
    • Wolfgang Sippl
    • Laurent Bischoff
    • A. Ganesan

    Philosophical Transactions of the Royal Society B: Biological Sciences ; Volume: 373 ; Page: 20170364

    HAL DOI

  • A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

    • Conrad Simoben
    • Dina Robaa
    • Alokta Chakrabarti
    • Karin Schmidtkunz
    • Martin Marek
    • Julien Lancelot
    • Srinivasaraghavan Kannan
    • Jelena Melesina
    • Tajith Shaik
    • Raymond J. Pierce
    • Christophe Romier
    • Manfred Jung
    • Wolfgang Sippl

    Molecules ; Volume: 23 ; Page: 566

    HAL DOI

• 2017

  • Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

    • Tino Heimburg
    • Fiona Kolbinger
    • Patrik Zeyen
    • Ehab Ghazy
    • Daniel Herp
    • Karin Schmidtkunz
    • Jelena Melesina
    • Tajith Baba Shaik
    • Frank Erdmann
    • Matthias Schmidt
    • Christophe Romier
    • Dina Robaa
    • Olaf Witt
    • Ina Oehme
    • Manfred Jung
    • Wolfgang Sippl

    Journal of Medicinal Chemistry ; Volume: 60 ; Page: 10188-10204

    HAL DOI

  • Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni

    • Leticia Anderson
    • Monete Gomes
    • Lucas Dasilva
    • Adriana da Silva Andrade Pereira
    • Marina Mourão
    • Christophe Romier
    • Raymond Pierce
    • Sergio Verjovski-Almeida

    PLoS Neglected Tropical Diseases ; Volume: 11

    HAL DOI

  • Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

    • Viktoria Krieger
    • Alexandra Hamacher
    • Christoph Gertzen
    • Johanna Senger
    • Martijn Zwinderman
    • Martin Marek
    • Christophe Romier
    • Frank Dekker
    • Thomas Kurz
    • Manfred Jung
    • Holger Gohlke
    • Matthias Kassack
    • Finn Hansen

    Journal of Medical Chemistry ; Volume: 60 ; Page: 5493-5506

    HAL DOI

  • Alkoxyurea-based histone deacetylase inhibitors increase cisplatin potency in chemoresistant cancer cell lines

    • Katharina Stenzel
    • Alexandra Hamacher
    • Finn Hansen
    • Christoph Gertzen
    • Johanna Senger
    • Viktoria Marquardt
    • Linda Marek
    • Martin Marek
    • Christophe Romier
    • Marc Remke
    • Manfred Jung
    • Holger Gohlke
    • Matthias Kassack
    • Thomas Kurz

    Journal of Medicinal Chemistry ; Volume: 60 ; Page: 5334-5348

    HAL DOI

  • Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni

    • Katharina Stenzel
    • Alokta Chakrabarti
    • Jelena Melesina
    • Finn Hansen
    • Julien Lancelot
    • Simon Herkenhohner
    • Beate Lungerich
    • Martin Marek
    • Christophe Romier
    • Raymond Pierce
    • Wolfgang Sippl
    • Manfred Jung
    • T Kurz

    Arch Pharm (Weinheim) ; Volume: 350

    HAL DOI

• 2016

  • Molecular basis and specificity of H2A.Z–H2B recognition and deposition by the histone chaperone YL1

    • Chrysa Latrick
    • Martin Marek
    • Khalid Ouararhni
    • Christophe Papin
    • Isabelle Stoll
    • Maria Ignatyeva
    • Arnaud Obri
    • Eric Ennifar
    • Stefan Dimitrov
    • Christophe Romier
    • Ali Hamiche

    Nature Structural and Molecular Biology ; Volume: 23 ; Page: 309-316

    HAL DOI

  • Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

    • J. Senger
    • J. Melesina
    • Martin Marek
    • Christophe Romier
    • I. Oehme
    • O. Witt
    • W. Sippl
    • M. Jung

    Journal of Medicinal Chemistry ; Volume: 59 ; Page: 1545-55

    HAL DOI

  • Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni

    • Martin Marek
    • Tajith Baba Shaik
    • Sylvie Duclaud
    • R. J. Pierce
    • Christophe Romier

    Methods in Molecular Biology ; Volume: 1436 ; Page: 109-18

    HAL DOI