Bases Moléculaires de la Régulation de la Chromatine et de la Transcription
Chef d'équipe : Christophe ROMIER
Département : Biologie structurale intégrative
Christophe ROMIER
Chercheur
romier@igbmc.fr
Équipe(s)
Publications
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2021
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Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
- Sébastien Coassolo
- Guillaume Davidson
- Luc Negroni
- Giovanni Gambi
- Sylvain Daujat
- Christophe Romier
- Irwin Davidson
Nature Communications ; Volume: 12
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Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity
- Hany S. Ibrahim
- Mohamed Abdelsalam
- Yanira Zeyn
- Mathes Zessin
- Al-Hassan Mustafa
- Marten A. Fischer
- Patrik Zeyen
- Ping Sun
- Emre F. Bulbul
- Anita Vecchio
- Frank Erdmann
- Matthias Schmidt
- Dina Robaa
- Cyril Barinka
- Christophe Romier
- Mike Schutkowski
- Oliver H. Kramer
- Wolfgang Sippl
International Journal of Molecular Sciences ; Volume: 23 ; Page: 369
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2020
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Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1
- Ehab Ghazy
- Patrik Zeyen
- Daniel Herp
- Martin Hügle
- Karin Schmidtkunz
- Frank Erdmann
- Dina Robaa
- Matthias Schmidt
- Elizabeth Morales
- Christophe Romier
- Stefan Günther
- Manfred Jung
- Wolfgang Sippl
European Journal of Medicinal Chemistry ; Volume: 200 ; Page: 112338
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2019
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Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors
- Dmitrii V. Kalinin
- Sunit K. Jana
- Maxim Pfafenrot
- Alokta Chakrabarti
- Jelena Melesina
- Tajith B. Shaik
- Julien Lancelot
- Raymond J. Pierce
- Wolfgang Sippl
- Christophe Romier
- Manfred Jung
- Ralph Holl
ChemMedChem ; Volume: 15 ; Page: 571-584
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One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity
- Matthes Zessin
- Zsófia Kutil
- Marat Meleshin
- Zora Nováková
- Ehab Ghazy
- Diana Kalbas
- Martin Marek
- Christophe Romier
- Wolfgang Sippl
- Cyril Bařinka
- Mike Schutkowski
Biochemistry ; Volume: 58 ; Page: 4777-4789
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Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni ( Sm Sirt2)
- Daria Monaldi
- Dante Rotili
- Julien Lancelot
- Martin Marek
- Nathalie Wössner
- Alessia Lucidi
- Daniela Tomaselli
- Elizabeth Ramos-Morales
- Christophe Romier
- Raymond J. Pierce
- Antonello Mai
- Manfred Jung
Journal of Medicinal Chemistry ; Volume: 62 ; Page: 8733-8759
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Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors
- Katharina Vögerl
- Nghia Ong
- Johanna Senger
- Daniel Herp
- Karin Schmidtkunz
- Martin Marek
- Martin Müller
- Karin Bartel
- Tajith Shaik
- Nicholas Porter
- Dina Robaa
- David W. Christianson
- Christophe Romier
- Wolfgang Sippl
- Manfred Jung
- Franz Bracher
Journal of Medicinal Chemistry ; Volume: 62 ; Page: 1138-1166
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2018
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Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants
- Martin Marek
- Tajith Shaik
- Tino Heimburg
- Alokta Chakrabarti
- Julien Lancelot
- Elizabeth Ramos-Morales
- Cyrielle da Veiga
- Dmitrii Kalinin
- Jelena Melesina
- Dina Robaa
- Karin Schmidtkunz
- Takayoshi Suzuki
- Ralph Holl
- Eric Ennifar
- Raymond Pierce
- Manfred Jung
- Wolfang Sippl
- Christophe Romier
Journal of Medicinal Chemistry ; Volume: 61 ; Page: 10000-10016
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Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies
- Margherita Brindisi
- Johanna Senger
- Caterina Cavella
- Alessandro Grillo
- Giulia Chemi
- Sandra Gemma
- Dora Mariagrazia Cucinella
- Stefania Lamponi
- Federica Sarno
- Concetta Iside
- Angela Nebbioso
- Ettore Novellino
- Tajith Baba Shaik
- Christophe Romier
- Daniel Herp
- Manfred Jung
- Stefania Butini
- Giuseppe Campiani
- Lucia Altucci
- Simone Brogi
European Journal of Medicinal Chemistry ; Volume: 157 ; Page: 127-138
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Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity
- Bertrand Lecointre
- Remy Narozny
- Maria Teresa Borrello
- Johanna Senger
- Alokta Chakrabarti
- Manfred Jung
- Martin Marek
- Christophe Romier
- Jelena Melesina
- Wolfgang Sippl
- Laurent Bischoff
- A. Ganesan
Philosophical Transactions of the Royal Society B: Biological Sciences ; Volume: 373 ; Page: 20170364
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