Guillaume PAVLOVIC

Engineer
Head of Unit
guillaume.pavlovic@igbmc.fr
Dr. Guillaume Pavlovic is Head of Genetic Engineering and Model Validation at PHENOMIN- Institut Clinique de la Souris (https://www.phenomin.fr), one of the largest French academic centres in phenogenomics and a founding member of the CELPHEDIA infrastructure (a national operational research infrastructure for animal research; https://celphedia.eu). His work consists of supporting the scientific community, both public and private, which has led to the development of 1,500 genetically modified rodent models. Guillaume therefore manages a range of services including genome engineering, expression analysis and microbiome metagenomics. He participates, and on several occasions coordinates for the ICS, various large national and international academic projects or collaborations with the industry.
As a technologist, he has built and applied a wide range of technologies, including recognized expertise in CRISPR/Cas9 genome editing and advanced molecular biology.
As a scientist, Guillaume has a keen interest in research reproducibility. He is actively involved in this topic as a trainer, reviewer, co-editor of journals or expert for the evaluation of infrastructure or scientific projects. In recent years, he and his team have been particularly active in publishing technical papers or reviews.
Publications
2017
Article in a journal
Nox4 genetic inhibition in experimental hypertension and metabolic syndrome
- Ghina Bouabout
- Estelle Ayme-Dietrich
- Hugues Jacobs
- Marie-France Champy Methlin
- Marie-Christine Birling
- Guillaume Pavlovic
- Lola Madeira
- Lahcen El Fertak
- Benoît Petit-Demoulière
- Tania Sorg-Guss
- Yann Hérault
- John Mudgett
- Laurent Monassier
Archives of cardiovascular diseases ; Volume: 111 ; Page: 41-52
Article in a journal
Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies
- Olivia Wendling
- Marie-France Champy Methlin
- Solène Jaubert
- Guillaume Pavlovic
- Aline Dubos
- Loic Lindner
- Hugues Jacobs
- Manuel Mark
- Roy Combe
- Isabelle Goncalves da Cruz
- Hervé Luche
- John Mudgett
- Thomas Rosahl
- Tania Sorg-Guss
- Marie Malissen
- Patrick Reilly
- Yann Herault
Scientific Reports ; Volume: 7
Article in a journal
Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE
- Marie-Christine Birling
- Laurence Schaeffer
- Philippe Andre
- Loic Lindner
- Damien Marechal
- Abdelkader Ayadi
- Tania Sorg-Guss
- Guillaume Pavlovic
- Yann Herault
Scientific Reports ; Volume: 7
Article in a journal
Modeling human disease in rodents by CRISPR/Cas9 genome editing
- Marie-Christine Birling
- Yann Herault
- Guillaume Pavlovic
Mammalian Genome ; Volume: 28 ; Page: 291-301
Article in a journal
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
- Terrence Meehan
- Nathalie Conte
- David West
- Julius Jacobsen
- Jeremy Mason
- Jonathan Warren
- Chao Chen
- Ilinca Tudose
- Mike Relac
- Peter Matthews
- Natasha Karp
- Luis Santos
- Tanja Fiegel
- Natalie Ring
- Henrik Westerberg
- Simon Greenaway
- Duncan Sneddon
- Hugh Morgan
- Gemma Codner
- Michelle Stewart
- ...
Nature Genetics ; Volume: 49 ; Page: 1231-1238
2016
Article in a journal
Physiological Expression of AMPKγ2 Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice
- Xiaodong Yang
- John Mudgett
- Ghina Bou About
- Marie-France Champy Methlin
- Hugues Jacobs
- Laurent Monassier
- Guillaume Pavlovic
- Tania Sorg-Guss
- Yann Hérault
- Benoît Petit-Demoulière
- Ku Lu
- Wen Feng
- Hongwu Wang
- Li-Jun Ma
- Roger Askew
- Mark D. Erion
- David E. Kelley
- Robert W. Myers
- Cai Li
- Hong-Ping Guan
Journal of Biological Chemistry ; Volume: 291 ; Page: 23428-23439
Article in a journal
E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis
- Perrine Goguet-Rubio
- Berfin Seyran
- Laurie Gayte
- Florence F. Bernex
- Anne Sutter
- Hélène Delpech
- Laetitia Karine Linares
- Romain Riscal
- Cendrine Repond
- Genevieve Rodier
- Olivier Kirsh
- Jawida Touhami
- Jean Noel
- Charles Vincent
- Nelly Pirot
- G Pavlovic
- Yann Hérault
- Marc Sitbon
- Luc Pellerin
- Claude Sardet
- ...
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 113 ; Page: 11004-11009
Article in a journal
Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction
- G. F. Codner
- Loic Lindner
- A. Caulder
- Marie Wattenhofer-Donze
- A. Radage
- Annelyse Mertz
- Benjamin Eisenmann
- Joffrey Mianne
- E. P. Evans
- C. V. Beechey
- M. D. Fray
- Marie-Christine Birling
- Yann Herault
- Guillaume Pavlovic
- L. Teboul
BMC Cell Biology ; Volume: 17
2015
Article in a journal
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
- Martin Hrabě de Angelis
- George Nicholson
- Mohammed Selloum
- Jacqueline White
- Hugh Morgan
- Ramiro Ramirez-Solis
- Tania Sorg
- Sara Wells
- Helmut Fuchs
- Martin Fray
- David Adams
- Niels Adams
- Thure Adler
- Antonio Aguilar-Pimentel
- Dalila Ali-Hadji
- Gregory Amann
- Philippe André
- Sarah Atkins
- Aurelie Auburtin
- Abdel Ayadi
- ...
Nature Genetics ; Volume: 47 ; Page: 969-978
Article in a journal
La révolution de la génomique fonctionnelle
- Guillaume Pavlovic
- Tania Sorg
- Ali Ayadi
- Marie-Christine Birling
- Isabelle Goncalves
- C Fremont
- B Malissen
- Yann Hérault
Biofutur ; Volume: 34 ; Page: 47-53