
Genomeast
GenomEast
PLATFORM LEADER
With over 20 years of experience, we offer a wide range of services to explore genomes, their expression and regulation, from quality control of starting samples to data analysis. These services are intended for the entire scientific community, national and international, public and private.
The platform is a member of the central core of the France Genomics National Research Infrastructure
The platform is IBISA certified.
Currently equipped with an Illumina NextSeq 2000 and a MGI DNBSEQ-G400 sequencers, we are carrying out projects to analyse :
of the transcriptome :
- RNA-seq
- Single cell RNA-seq (scRNA-seq)
- Spatial transcriptomics
of the epigenome :
- ChIP-seq
- Cut & Run
- MeDIP-seq
- We also have experience in sequencing your ATAC-seq or Cut & Tag libraries
of the genome :
- Targeted regions of the genome (exome, regions of interest)
- Full genome sequencing
multiomics :
- Single Cell Multiome ATAC + Gene Expression
For these projects, we prepare and sequence your libraries, performing quality controls at each step. We can also perform the bioinformatics analysis of your data. We have expertise in a wide variety of applications and have developed dedicated bioinformatics pipelines to analyze the corresponding results.
Alternatively, you can use our sequencing capabilityto sequence your own libraries as long as they are compatible with Illumina technology.
How to submit a project to GenomEast?
Via our web interface
All our services are governed by the general terms and conditions of sale, which take precedence over any conditions of purchase, unless otherwise agreed in writing by us. You can also consult our Data Management Plan.
We regularly share our knowledge and expertise through various courses and training sessions, including:
- The "High Throughput Approaches" course at the Ecole Supérieure de Biotechnologie de Strasbourg (ESBS)
- The "Omics 2" course of the Master 2 Biology-Health, Biomedicine Research course at the University of Strasbourg
- The PhD Program of the IMCBio University Research School in Strasbourg
- The DU "High-throughput sequencing and rare diseases" at the University of Dijon
- The AVIESAN IFB Inserm bioinformatics school
- The organisation of training courses in bioinformatics for high-throughput sequencing with Inserm and the CNRS
Other equipments:
- High-throughput sequencing: iSeq100 (Illumina)
- High-throughput nanofluidics: Chromium Controller (10X Genomics)
- Spatial transcriptomics: GeoMx Digital Spatial Profiler (NanoString)
- Quality control : Varioskan Flash Reader and Qubit Fluorometer (Thermo Fisher), 2100 Bioanalyzer and AATI Fragment Analyzer (Agilent)
- Sonicator : E220 AFA system (Covaris)
- IT Infrastructure : computing power (Dell): 304 cores, storage (Lenovo, GPFS): 750 TB
France Génomique
Our platform has been a partner of the France Genomics network since the initial selection of the project within the framework of the "Investissements d'avenir" in 2011. This network brings together and shares the resources of the main French genomics and bioinformatics platforms.
Fondation maladies rares
Since 2011, we have been one of the partner platforms of the Fondation maladies rares for the implementation of the "GenOmics: high throughput sequencing & rare diseases" programme, which aims to unravel the genetic and molecular basis of rare diseases using high throughput sequencing.
IBiSA and CoRTecS
Since 2008, we have been part of the national network of platforms and resource centers in biology, health, and agronomy of the GIS IBiSA, and since 2021, part of the regional CoRTecS network, which brings together the scientific research and service platforms of the University of Strasbourg.
New applications and technologies
Over the past years, we have gained a strong expertise in single-cell sequencing technologies (Research Expertise 2021 prize from the University of Strasbourg). We further implement new applications each year. At the same time, we are implementing two complementary technologies dedicated to spatial transcriptomics: Visium (10X Genomics) and GeoMx (NanoString).
Publications
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2025
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Compromised retinoic acid receptor beta expression accelerates the onset of motor, cellular and molecular abnormalities in a mouse model of Huntington’s disease
- Nicolas Zinter
- Tao Ye
- Hanna Semaan
- Valerie Fraulob
- Damien Plassard
- Wojciech Krezel
Neurobiology of Disease ; Volume: 212 ; Page: 106943
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Assessment of the effects of estetrol and 17α-ethinylestradiol on zebrafish (Danio rerio) metamorphosis: a morphological and transcriptomic approach
- Nathalie Leroux
- Sébastien Baekelandt
- Jean-Baptiste Robert
- Laura Burattin
- Céline Keime
- Céline Gérard
- Patrick Kestemont
Elsevier BV ; Volume: 376 ; Page: 126423
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The transcription factor IID subunit Taf13 is dispensable for TATA binding protein promoter recruitment and RNA polymerase II transcription
- Igor Martianov
- Stephanie Le Gras
- Guillaume Davidson
- Irwin Davidson
Elsevier BV ; Volume: 28 ; Page: 112286
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Hippocampal Astrocyte Morphology Follows an Unexpected Trajectory With Age in a Transgenic Rodent Model of Tauopathy.
- E. Augustin
- T. Vinasco-Sandoval
- M. Riquelme-Perez
- D. Plassard
- M. Gaudin
- G. Aurégan
- J. Mitja
- S. Bernier
- C. Joséphine
- F. Petit
- C. Jan
- A. S. Hérard
- M. C. Gaillard
- Agathe Launay
- Emilie Faivre
- Luc Buee
- A. L. Boutillier
- David Blum
- A. P. Bemelmans
- G. Bonvento
- ...
Glia
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TFE3 fusions drive oxidative metabolism and ferroptosis resistance in translocation renal cell carcinoma
- Alexandra Helleux
- Guillaume Davidson
- Antonin Lallement
- Fatima Al Hourani
- Alexandre Haller
- Isabelle Michel
- Anas Fadloun
- Christelle Thibault-Carpentier
- Xiaoping Su
- Véronique Lindner
- Thibault Tricard
- Hervé Lang
- Nizar M Tannir
- Irwin Davidson
- Gabriel G Malouf
Springer Science and Business Media LLC ; Volume: 17 ; Page: 1041-1070
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CREB3 gain of function variants protect against ALS
- Salim Megat
- Christine Marques
- Marina Hernán-Godoy
- Chantal Sellier
- Geoffrey Stuart-Lopez
- Sylvie Dirrig-Grosch
- Charlotte Gorin
- Aurore Brunet
- Mathieu Fischer
- Céline Keime
- Pascal Kessler
- Marco Antonio Mendoza-Parra
- Ramona A. J. Zwamborn
- Jan H. Veldink
- Sonja W. Scholz
- Luigi Ferrucci
- Albert Ludolph
- Bryan Traynor
- Adriano Chio
- Luc Dupuis
- ...
Springer Science and Business Media LLC ; Volume: 16
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Negative energy balance by feed deprivation affects the adipose miRNome in the lactating goat
- Yannick Faulconnier
- Tao Ye
- Christine Leroux
Journal of Animal Science ; Volume: 103
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Gene-specific transcript buffering revealed by perturbation of coactivator complexes
- Faezeh Forouzanfar
- David F Moreno
- Damien Plassard
- Audrey Furst
- Karen Amaral de Oliveira
- Bernardo Reina San Martin
- Làszlo Tora
- Nacho Molina
- Manuel Mendoza
Science Advances ; Volume: 11 ; Page: eadr1492
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Transcriptomic analysis of human primary T cells after short-term leucine-deprivation and evaluation of kinase GCN2’s role in regulating differential gene expression
- Aurore Dougé
- Gwendal Cueff
- Céline Keime
- Valérie Carraro
- Céline Jousse
- Paul Rouzaire
- Alain Bruhat
PLoS ONE ; Volume: 20 ; Page: e0317505
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Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1
- Baptiste Brulé
- Rafael Alcalá-Vida
- Noémie Penaud
- Jil Scuto
- Coline Mounier
- Jonathan Seguin
- Sina Vincent Khodaverdian
- Brigitte Cosquer
- Etienne Birmelé
- Stéphanie Le Gras
- Charles Decraene
- Anne-Laurence Boutillier
- Karine Merienne
Nature Communications ; Volume: 16 ; Page: 1550
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