
Genomeast
GenomEast
PLATFORM LEADER
With over 20 years of experience, we offer a wide range of services to explore genomes, their expression and regulation, from quality control of starting samples to data analysis. These services are intended for the entire scientific community, national and international, public and private.
The platform is a member of the central core of the France Genomics National Research Infrastructure
The platform is IBISA certified.
Currently equipped with an Illumina NextSeq 2000 sequencer, we are carrying out projects to analyse :
of the transcriptome :
- RNA-seq
- small RNA-seq
- Single cell RNA-seq (scRNA-seq)
of the epigenome :
- ChIP-seq
- Cut & Run
- MeDIP-seq
- We also have experience in sequencing your ATAC-seq or Cut & Tag libraries
of the genome :
- Targeted regions of the genome (exome, regions of interest)
- Full genome sequencing
multiomics :
- Single Cell Multiome ATAC + Gene Expression
For these projects, we prepare and sequence your libraries, performing quality controls at each step. We can also perform the bioinformatics analysis of your data. We have expertise in a wide variety of applications and have developed dedicated bioinformatics pipelines to analyze the corresponding results.
Alternatively, you can use our sequencing capabilityto sequence your own libraries as long as they are compatible with Illumina technology.
How to submit a project to GenomEast?
Via our web interface
All our services are governed by the general terms and conditions of sale, which take precedence over any conditions of purchase, unless otherwise agreed in writing by us.
We regularly share our knowledge and expertise through various courses and training sessions, including:
- The "High Throughput Approaches" course at the Ecole Supérieure de Biotechnologie de Strasbourg (ESBS)
- The "Omics 2" course of the Master 2 Biology-Health, Biomedicine Research course at the University of Strasbourg
- The PhD Program of the IMCBio University Research School in Strasbourg
- The DU "High-throughput sequencing and rare diseases" at the University of Dijon
- The AVIESAN IFB Inserm bioinformatics school
- The organisation of training courses in bioinformatics for high-throughput sequencing with Inserm and the CNRS
Other equipments:
- High-throughput sequencing: iSeq100 (Illumina)
- High-throughput nanofluidics: Chromium Controller (10X Genomics)
- Spatial transcriptomics: GeoMx Digital Spatial Profiler (NanoString)
- Quality control : Varioskan Flash Reader and Qubit Fluorometer (Thermo Fisher), 2100 Bioanalyzer and AATI Fragment Analyzer (Agilent)
- Sonicator : E220 AFA system (Covaris)
- IT Infrastructure : computing power (Dell): 304 cores, storage (Lenovo, GPFS): 750 TB
France Génomique
Our platform has been a partner of the France Genomics network since the initial selection of the project within the framework of the "Investissements d'avenir" in 2011. This network brings together and shares the resources of the main French genomics and bioinformatics platforms.
Fondation maladies rares
Since 2011, we have been one of the partner platforms of the Fondation maladies rares for the implementation of the "GenOmics: high throughput sequencing & rare diseases" programme, which aims to unravel the genetic and molecular basis of rare diseases using high throughput sequencing.
CORTECS
Starting 2021, we belong to the CORTECS network, which groups together the Scientific Research and Services Platforms of the University of Strasbourg in partnership with SATT Conectus Alsace and the services of the CNRS and INSERM.
New applications and technologies
Over the past years, we have gained a strong expertise in single-cell sequencing technologies (Research Expertise 2021 prize from the University of Strasbourg). We further implement new applications each year. At the same time, we are implementing two complementary technologies dedicated to spatial transcriptomics: Visium (10X Genomics) and GeoMx (NanoString).
Publications
2023
Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors
- Julie Terzic
- Mohamed Abu El Maaty
- Régis Lutzing
- Alexandre Vincent
- Rana El Bizri
- Matthieu Jung
- Céline Keime
- Daniel Metzger
EMBO Molecular Medicine
Peroxisomal defects in microglial cells induce a disease-associated microglial signature
- Quentin Raas
- Ali Tawbeh
- Mounia Tahri-Joutey
- Catherine Gondcaille
- Céline Keime
- Romain Kaiser
- Doriane Trompier
- Boubker Nasser
- Valerio Leoni
- Emma Bellanger
- Maud Boussand
- Yannick Hamon
- Alexandre Benani
- Francesca Di Cara
- Caroline Truntzer
- Mustapha Cherkaoui-Malki
- Pierre Andreoletti
- Stéphane Savary
Frontiers in Molecular Neuroscience ; Volume: 16
A time- and space-resolved nuclear receptor atlas in mouse liver
- Francesco Paolo Zummo
- Alexandre Berthier
- Céline Gheeraert
- Manjula Vinod
- Marie Bobowski-Gérard
- Olivier Molendi-Coste
- Laurent Pineau
- Matthieu Jung
- Loic Guille
- Julie Chevalier-Dubois
- David Dombrowicz
- Bart Staels
- Jérôme Eeckhoute
- Philippe Lefebvre
Journal of Molecular Endocrinology
Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice
- Florence Blot
- Justine Marchix
- Miriam Ejarque
- Sara Jimenez
- Aline Meunier
- Céline Keime
- Camille Trottier
- Mikaël Croyal
- Céline Lapp
- Maxime Mahe
- Adèle de Arcangelis
- Gérard Gradwohl
Cellular and Molecular Gastroenterology and Hepatology
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
- Lucía Ramos-Alonso
- Petter Holland
- Stéphanie Le Gras
- Xu Zhao
- Bernard Jost
- Magnar Bjørås
- Yves Barral
- Jorrit Enserink
- Pierre Chymkowitch
Proceedings of the National Academy of Sciences ; Volume: 120
Proprioceptors-enriched neuronal cultures from induced pluripotent stem cells from Friedreich ataxia patients show altered transcriptomic and proteomic profiles, abnormal neurite extension, and impaired electrophysiological properties
- Chiara Dionisi
- Marine Chazalon
- Myriam Rai
- Céline Keime
- Virginie Imbault
- David Communi
- Hélène Puccio
- Serge Schiffmann
- Massimo Pandolfo
Brain Communications ; Volume: 5
Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes
- Ferdinand Marlétaz
- Arnaud Couloux
- Julie Poulain
- Karine Labadie
- Corinne da Silva
- Sophie Mangenot
- Benjamin Noel
- Albert J Poustka
- Philippe Dru
- Cinta Pegueroles
- Marco Borra
- Elijah K Lowe
- Guy Lhomond
- Lydia Besnardeau
- Stéphanie Le Gras
- Tao Ye
- Daria Gavriouchkina
- Roberta Russo
- Caterina Costa
- Francesca Zito
- ...
Cell Genomics ; Volume: 3 ; Page: 100295
2022
Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects
- Edmone Dewaeles
- Kévin Carvalho
- Sandy Fellah
- Jaewon Sim
- Nihad Boukrout
- Raphaelle Caillierez
- Hariharan Ramakrishnan
- Cynthia van der Hauwaert
- Jhenkruthi Vijaya Shankara
- Nathalie Martin
- Noura Massri
- Agathe Launay
- Joseph Folger
- Clémentine de Schutter
- Romain Larrue
- Ingrid Loison
- Marine Goujon
- Matthieu Jung
- Stéphanie Le Gras
- Victoria Gomez-Murcia
- ...
The Journal of clinical investigation ; Volume: 132 ; Page: e152924
Loss of autism-candidate CHD8 perturbs neural crest development and intestinal homeostatic balance
- Gaëlle Hayot
- Mathieu Massonot
- Céline Keime
- Elodie Faure
- Christelle Golzio
Life Science Alliance ; Volume: 6
Distinct mechanisms underlie H2O2 sensing in C. elegans head and tail
- Sophie Quintin
- Théo Aspert
- Ye Tao
- Gilles Charvin
PLoS ONE ; Volume: 17 ; Page: e0274226.