Guillaume PAVLOVIC

Engineer
Head of Unit
guillaume.pavlovic@igbmc.fr
Dr. Guillaume Pavlovic is Head of Genetic Engineering and Model Validation at PHENOMIN- Institut Clinique de la Souris (https://www.phenomin.fr), one of the largest French academic centres in phenogenomics and a founding member of the CELPHEDIA infrastructure (a national operational research infrastructure for animal research; https://celphedia.eu). His work consists of supporting the scientific community, both public and private, which has led to the development of 1,500 genetically modified rodent models. Guillaume therefore manages a range of services including genome engineering, expression analysis and microbiome metagenomics. He participates, and on several occasions coordinates for the ICS, various large national and international academic projects or collaborations with the industry.
As a technologist, he has built and applied a wide range of technologies, including recognized expertise in CRISPR/Cas9 genome editing and advanced molecular biology.
As a scientist, Guillaume has a keen interest in research reproducibility. He is actively involved in this topic as a trainer, reviewer, co-editor of journals or expert for the evaluation of infrastructure or scientific projects. In recent years, he and his team have been particularly active in publishing technical papers or reviews.
Publications
2025
Article in a journal
Better understanding of laboratory animal genetics will improve reproducibility
- Guillaume Pavlovic
- Sara Wells
- Yann Hérault
- Lydia Teboul
PLoS Biology ; Volume: 23 ; Page: e3003464
2024
Article in a journal
Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines
- Hillary Elrick
- Kevin A Peterson
- Brandon J Willis
- Denise G Lanza
- Elif F Acar
- Edward J Ryder
- Lydia Teboul
- Petr Kasparek
- Marie-Christine Birling
- David J Adams
- Allan Bradley
- Robert E Braun
- Steve D Brown
- Adam Caulder
- Gemma F Codner
- Francesco J Demayo
- Mary E Dickinson
- Brendan Doe
- Graham Duddy
- Marina Gertsenstein
- ...
Scientific Reports ; Volume: 14 ; Page: 22626
Article in a journal
Improving laboratory animal genetic reporting: LAG-R guidelines
- Lydia Teboul
- James Amos-Landgraf
- Fernando J Benavides
- Marie-Christine Birling
- Steve D M Brown
- Elizabeth Bryda
- Rosie Bunton-Stasyshyn
- Hsian-Jean Chin
- Martina Crispo
- Fabien Delerue
- Michael Dobbie
- Craig L Franklin
- Ernst-Martin Fuchtbauer
- Xiang Gao
- Christelle Golzio
- Rebecca Haffner
- Yann Hérault
- Martin Hrabe de Angelis
- Kevin C Kent Lloyd
- Terry R Magnuson
- ...
Nature Communications ; Volume: 15
Article in a journal
Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice
- Daniel Holl
- Wing Fung Hau
- Anais Julien
- Shervin Banitalebi
- Jannis Kalkitsas
- Soniya Savant
- Enric Llorens-Bobadilla
- Yann Herault
- Guillaume Pavlovic
- Mahmood Amiry-Moghaddam
- David Oliveira Dias
- Christian Göritz
Nature Neuroscience ; Volume: 27 ; Page: 1285 - 1298
2023
Article in a journal
Increased On-Target Rate and Risk of Concatemerization after CRISPR-Enhanced Targeting in ES Cells
- Valérie Erbs
- Romain Lorentz
- Benjamin Eisenman
- Laurence Schaeffer
- Laurence Luppi
- Loic Lindner
- Yann Hérault
- Guillaume Pavlovic
- Marie Wattenhofer-Donzé
- Marie-Christine Birling
Genes ; Volume: 14 ; Page: 401
2021
Article in a journal
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
- Véronique Brault
- Thu Lan Nguyen
- Javier Flores-Gutiérrez
- Giovanni Iacono
- Marie-Christine Birling
- Valérie Lalanne
- Hamid Meziane
- Antigoni Manousopoulou
- Guillaume Pavlovic
- Loïc Lindner
- Mohammed Selloum
- Tania Sorg
- Eugene Yu
- Spiros D Garbis
- Yann Hérault
PLoS Genetics ; Volume: 17 ; Page: e1009777
Article in a journal
Droplet digital PCR or quantitative PCR for in-depth genomic and functional validation of genetically altered rodents
- Loic Lindner
- Pauline Cayrou
- Thomas W Rosahl
- Heather H Zhou
- Marie-Christine Birling
- Yann Herault
- Guillaume Pavlovic
Methods ; Volume: 191 ; Page: 107 - 119
Article in a journal
A resource of targeted mutant mouse lines for 5,061 genes
- Marie-Christine Birling
- Atsushi Yoshiki
- David Adams
- Shinya Ayabe
- Arthur Beaudet
- Joanna Bottomley
- Allan Bradley
- Steve Dm Brown
- Antje Bürger
- Wendy Bushell
- Francesco Chiani
- Hsian-Jean Genie Chin
- Skevoulla Christou
- Gemma Codner
- Francesco Demayo
- Mary Dickinson
- Brendan Doe
- Leah Rae Donahue
- Martin Fray
- Alessia Gambadoro
- ...
Nature Genetics
2020
Pre-publication, Working Document
BIN1 genetic risk factor for Alzheimer is sufficient to induce early structural tract alterations in entorhinal cortex-dentate gyrus pathway and related hippocampal multi-scale impairments
- R Daudin
- D Marechal
- Q Wang
- Y Abe
- N Bourg
- M Sartori
- Y Loe-Mie
- J Lipecka
- C Guerrera
- A Mckenzie
- B Potier
- P Dutar
- J Viard
- A.M Lepagnol-Bestel
- A Winkeler
- V Hindié
- Mc Birling
- L Lindner
- C Chevalier
- G Pavlovic
- ...
Article in a journal
Variability in Genome Editing Outcomes: Challenges for Research Reproducibility and Clinical Safety
- Lydia Teboul
- Yann Herault
- Sara Wells
- Waseem Qasim
- Guillaume Pavlovic
Molecular Therapy ; Volume: 28 ; Page: 1422-1431