Guillaume PAVLOVIC

Engineer
Head of Unit
guillaume.pavlovic@igbmc.fr
Dr. Guillaume Pavlovic is Head of Genetic Engineering and Model Validation at PHENOMIN- Institut Clinique de la Souris (https://www.phenomin.fr), one of the largest French academic centres in phenogenomics and a founding member of the CELPHEDIA infrastructure (a national operational research infrastructure for animal research; https://celphedia.eu). His work consists of supporting the scientific community, both public and private, which has led to the development of 1,500 genetically modified rodent models. Guillaume therefore manages a range of services including genome engineering, expression analysis and microbiome metagenomics. He participates, and on several occasions coordinates for the ICS, various large national and international academic projects or collaborations with the industry.
As a technologist, he has built and applied a wide range of technologies, including recognized expertise in CRISPR/Cas9 genome editing and advanced molecular biology.
As a scientist, Guillaume has a keen interest in research reproducibility. He is actively involved in this topic as a trainer, reviewer, co-editor of journals or expert for the evaluation of infrastructure or scientific projects. In recent years, he and his team have been particularly active in publishing technical papers or reviews.
Publications
2021
Article in a journal
Introduction to mammalian genome special issue: the microbiome in human health and disease
- Guillaume Pavlovic
- Je Kyung Seong
- George Weinstock
Mammalian Genome ; Volume: 32 ; Page: 205-205
Article in a journal
Droplet digital PCR or quantitative PCR for in-depth genomic and functional validation of genetically altered rodents
- Loic Lindner
- Pauline Cayrou
- Thomas W Rosahl
- Heather H Zhou
- Marie-Christine Birling
- Yann Herault
- Guillaume Pavlovic
Methods ; Volume: 191 ; Page: 107 - 119
Article in a journal
A resource of targeted mutant mouse lines for 5,061 genes
- Marie-Christine Birling
- Atsushi Yoshiki
- David Adams
- Shinya Ayabe
- Arthur Beaudet
- Joanna Bottomley
- Allan Bradley
- Steve Dm Brown
- Antje Bürger
- Wendy Bushell
- Francesco Chiani
- Hsian-Jean Genie Chin
- Skevoulla Christou
- Gemma Codner
- Francesco Demayo
- Mary Dickinson
- Brendan Doe
- Leah Rae Donahue
- Martin Fray
- Alessia Gambadoro
- ...
Nature Genetics
2020
Pre-publication, Working Document
BIN1 genetic risk factor for Alzheimer is sufficient to induce early structural tract alterations in entorhinal cortex-dentate gyrus pathway and related hippocampal multi-scale impairments
- R Daudin
- D Marechal
- Q Wang
- Y Abe
- N Bourg
- M Sartori
- Y Loe-Mie
- J Lipecka
- C Guerrera
- A Mckenzie
- B Potier
- P Dutar
- J Viard
- A.M Lepagnol-Bestel
- A Winkeler
- V Hindié
- Mc Birling
- L Lindner
- C Chevalier
- G Pavlovic
- ...
Article in a journal
Variability in Genome Editing Outcomes: Challenges for Research Reproducibility and Clinical Safety
- Lydia Teboul
- Yann Herault
- Sara Wells
- Waseem Qasim
- Guillaume Pavlovic
Molecular Therapy ; Volume: 28 ; Page: 1422-1431
2019
Article in a journal
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis
- Ekaterina Ivanova
- Johan Gilet
- Vadym Sulimenko
- Arnaud Duchon
- Gabrielle Rudolf
- Karen Runge
- Stephan Collins
- Laure Asselin
- Loic Broix
- Nathalie Drouot
- Peggy Tilly
- Patrick Nusbaum
- Alexandre Vincent
- William Magnant
- Valerie Skory
- Marie-Christine Birling
- Guillaume Pavlovic
- Juliette Godin
- Binnaz Yalcin
- Yann Hérault
- ...
Nature Communications ; Volume: 10 ; Page: 100-110
Article in a journal
Modeling Down syndrome in animals from the early stage to the 4.0 models and next
- Maria del Mar Muñiz Moreno
- Veronique Brault
- Yann Hérault
- Maria Del Mar
- Muñiz Moreno
- Véronique Brault
- Marie-Christine Birling
- Guillaume Pavlovic
- Yann Herault
Progress in brain research
Article in a journal
Optimizing PCR for Mouse Genotyping: Recommendations for Reliable, Rapid, Cost Effective, Robust and Adaptable to High‐Throughput Genotyping Protocol for Any Type of Mutation
- Sylvie Jacquot
- Nathalie Chartoire
- Francoise Piguet
- Yann Hérault
- Guillaume Pavlovic
Current Protocols in Mouse Biology ; Volume: 9
2018
Article in a journal
A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations
- Aline Dubos
- Hamid Meziane
- Giovanni Iacono
- Aurore Curie
- Fabrice Riet
- Christelle Martin
- Nadège Loaec
- Marie-Christine Birling
- Mohammed Selloum
- Elisabeth Normand
- Guillaume Pavlovic
- Tania Sorg
- Henk G. Stunnenberg
- Jamel Chelly
- Yann Humeau
- Gaëlle Friocourt
- Yann Herault
Human Molecular Genetics ; Volume: 27 ; Page: 2138-2153
2017
Article in a journal
Translation of Expanded CGG Repeats into FMRpolyG Is Pathogenic and May Contribute to Fragile X Tremor Ataxia Syndrome
- Chantal Sellier
- Ronald Buijsen
- Fang He
- Sam Natla
- Laura Jung
- Philippe Tropel
- Angeline Gaucherot
- Hugues Jacobs
- Hamid Meziane
- Alexandre Vincent
- Marie-France Champy
- Tania Sorg
- Guillaume Pavlovic
- Marie Wattenhofer-Donze
- Marie-Christine Birling
- Mustapha Oulad-Abdelghani
- Pascal Eberling
- Frank Ruffenach
- Mathilde Joint
- Mathieu Anheim
- ...
Neuron ; Volume: 93 ; Page: 331-347