Structural biology of epigenetic targets
Team Leader : Jean CAVARELLI
Department : Integrated structural biology
Jean CAVARELLI
Researcher
jean.cavarelli@igbmc.fr
Research team(s)
Publications
2022
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach
- Giulia Iannelli
- Ciro Milite
- Nils Marechal
- Vincent Cura
- Luc Bonnefond
- Nathalie Troffer-Charlier
- Alessandra Feoli
- Donatella Rescigno
- Yalong Wang
- Alessandra Cipriano
- Monica Viviano
- Mark Bedford
- Jean Cavarelli
- Sabrina Castellano
- Gianluca Sbardella
Journal of Medicinal Chemistry ; Volume: 65 ; Page: 11574-11606
2021
Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase
- Vincent Cura
- Jean Cavarelli
Life ; Volume: 11 ; Page: 1263
2020
FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts
- Thomas Di Mattia
- Arthur Martinet
- Souade Ikhlef
- Alastair G Mcewen
- Yves Nominé
- Corinne Wendling
- Pierre Poussin‐courmontagne
- Laetitia Voilquin
- Pascal Eberling
- Frank Ruffenach
- Jean Cavarelli
- John Slee
- Timothy P Levine
- Guillaume Drin
- Catherine Tomasetto
- Fabien Alpy
EMBO Journal ; Volume: 39
Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation
- Emmanuel Salomon
- Marjorie Schmitt
- Elisabeth Mouray
- Alastair G Mcewen
- Lotfi Bounaadja
- Morgan Torchy
- Pierre Poussin-Courmontagne
- Sarah Alavi
- Céline Tarnus
- Jean Cavarelli
- Isabelle Florent
- Sebastien Albrecht
Bioorganic Chemistry ; Volume: 98 ; Page: 103750
2018
Role of the SMN complex and the methylosome in selenoprotein mRNP assembly and translation
- Anne-Sophie Gribling-Burrer
- Hassan Hayek
- Vincent Cura
- Martine Barkats
- Jean Cavarelli
- Séverine Massenet
- Franck Martin
- Gilbert Eriani
- Christine Allmang
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors
- Ludovic Halby
- Nils Marechal
- Dany Pechalrieu
- Vincent Cura
- Don-Marc Franchini
- Céline Faux
- Frédéric Alby
- Nathalie Troffer-Charlier
- Srikanth Kudithipudi
- Albert Jeltsch
- Wahiba Aouadi
- Etienne Decroly
- Jean-Claude Guillemot
- Patrick Page
- Clotilde Ferroud
- Luc Bonnefond
- Dominique Guianvarc'H
- Jean Cavarelli
- Paola Arimondo
Philosophical Transactions of the Royal Society B: Biological Sciences ; Volume: 373 ; Page: 20170072
2017
Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1
- Matthijs van Haren
- Nils Marechal
- Nathalie Troffer-Charlier
- Agostino Cianciulli
- Gianluca Sbardella
- Jean Cavarelli
- Nathaniel Martin
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 114 ; Page: 3625-3630
Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors
- Vincent Cura
- N Marechal
- N Troffer-Charlier
- Jean-Marc Strub
- M van Haren
- Nathaniel I. Martin
- Sarah Cianferani
- Luc Bonnefond
- Jean Cavarelli
FEBS J ; Volume: 284 ; Page: 77-96
SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation
- Anne-Sophie Gribling-Burrer
- Michael Leichter
- Laurence Wurth
- Alexandra Huttin
- Florence Schlotter
- Nathalie Troffer-Charlier
- Vincent Cura
- Martine Barkats
- Jean Cavarelli
- Séverine Massenet
- Christine Allmang
Nucleic Acids Research ; Volume: 45 ; Page: 5399-5413
Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis
- G Peng
- A Mcewen
- V Olieric
- Céline Schmitt
- Sébastien Albrecht
- Jean Cavarelli
- Celine Tarnus
Proteins ; Volume: 85 ; Page: 1413-1421