Congratulations to Guillaume Davidson on the acceptance of his thesis!
Congratulations to Guillaume Davidson for the acceptance of his thesis. His work was directed by Gabriel Malouf and titled: "Exploring the roles of cell plasticity and tumor heterogeneity in renal cell carcinoma: implications on development, progression and response to immunotherapy".
During his thesis, Guillaume Davidson studied clear-cell renal cell carcinoma (ccRCC) through single-cell RNA-sequencing and spatial transcriptomics. With his work, he showed that ccRCC cancer cells are capable of epithelial-mesenchymal plasticity and that a population of undifferentiated and invasive mesenchymal ccRCC cells cooperate with myofibroblastic cancer-associated fibroblasts for invasion, metastasis and resistance to immunotherapy.
Want to know more ? You can read this article published in the journal Cancer Research : https://doi.org/10.1158/0008-5472.CAN-22-3034
During his time at IGBMC, the PhD student was able to develop skills in cutting edge technologies such as data analysis for single-cell RNA-sequencing and spatial transcriptomics.
Thanks to our Genomeast platform for providing their help with sequencing and insightful discussions about data analysis. As a bioinformatician, Guillaume Davidson also heavily collaborated with Alexandra Helleux, from Irwin Davidson’s team.
Thanks to ARC Foundation, Ligue Nationale contre le Cancer, l’Institut National du Cancer et la Région Grand-Est for the support they provided.
Guillaume Davidson will continue with us for a few month as post-doctoral researcher to finish his project and supports others projects involving bioinformatics!