Contact
 

Congratulations to Nour EL KHAZEN on earning their PhD!

Brèves |

Her work, supervised by: Minchul KIM 
is entitled:“Dynamics, specialization and function of muscle nuclei in skeletal muscle".

  • Summary of her research work:
    Skeletal muscle is a multinucleated syncytium constantly exposed to mechanical and metabolic stress. Within this shared cytoplasm, myonuclei do not form a static population but undergo 
    continuous turnover under homeostatic conditions. This renewal is not uniform along the fiber and is particularly pronounced at the myotendinous junction. Oxidative stress contributes to triggering 
    selective nuclear elimination, with autophagy acting as the central effector mechanism. When this process is impaired, nuclei displaying inflammatory and senescent features accumulate, linking 
    nuclear dynamics to long-term muscle homeostasis. 
    In parallel, the development of viral and genetic mouse tools enabled the detection and characterization of specialized myonuclear subtypes within defined muscle domains, highlighting the spatial organization of nuclear function in adult muscle. 
    Together, these findings position adult skeletal muscle as a dynamic and spatially organized nuclear system maintained through continuous quality control.
     
  • Skills acquired at the IGBMC:
    During my four years at the IGBMC, I developed my independence, perseverance, and strong work ethic, as well as solid experimental and organizational skills. I also strengthened my ability to manage research projects, troubleshoot experimental issues, and work effectively in a scientific environment.
     
  • Life at the IGBMC:
    What I particularly appreciate about the institute is the open access to its various core facilities, as well as the wide range and regularity of the seminars offered. These opportunities foster continuous learning, scientific exchange, and exposure to new research approaches.
     
  • Funding and partners:
    Inserm
     
  • Future projects:
    At this stage of my career, I do not yet have a specific plan for the future, but I remain open to exploring different opportunities.