Differentiation and physiopathology of endocrine cells in the pancreas and intestine
Team Leader : Gerard GRADWOHL
Department : Development and stem cells
Gerard GRADWOHL
Researcher
gradwohl@igbmc.fr
Research team(s)
Publications
2025
Article in a journal
Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation
- Christine Ebeid
- Adam Rump
- Chenglei Tian
- Anant Mamidi
- Adèle de Arcangelis
- Gérard Gradwohl
- Henrik Semb
EMBO Reports ; Page: Online ahead of print
Article in a journal
Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development
- Sara Jiménez
- Florence Blot
- Aline Meunier
- Rishabh Kapoor
- Valérie Schreiber
- Colette Giethlen
- Sabitri Ghimire
- Maxime Mahe
- Nacho Molina
- Adèle de Arcangelis
- Gérard Gradwohl
Biology Open ; Volume: 14 ; Page: bio062083
2023
Article in a journal » Data paper
Characterization of cell-fate decision landscapes by estimating transcription factor dynamics
- Sara Jiménez
- Valérie Schreiber
- Reuben Mercier
- Gérard Gradwohl
- Nacho Molina
Cell Reports Methods ; Page: 100512
Article in a journal
Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice
- Florence Blot
- Justine Marchix
- Miriam Ejarque
- Sara Jimenez
- Aline Meunier
- Céline Keime
- Camille Trottier
- Mikaël Croyal
- Céline Lapp
- Maxime Mahe
- Adèle de Arcangelis
- Gérard Gradwohl
Cellular and Molecular Gastroenterology and Hepatology
2021
Article in a journal
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network
- Valérie Schreiber
- Reuben Mercier
- Sara Jiménez
- Tao Ye
- Emmanuel García-Sánchez
- Annabelle Klein
- Aline Meunier
- Sabitri Ghimire
- Catherine Birck
- Bernard Jost
- Kristian Honnens de Lichtenberg
- Christian Honoré
- Palle Serup
- Gérard Gradwohl
Molecular metabolism ; Volume: 53 ; Page: 101313
Article in a journal
Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells
- Kaare V. Grunddal
- Sarah Tonack
- Kristoffer L. Egerod
- Jonanthan James Thompson
- Natalia Petersen
- Maja S. Engelstoft
- Constance Vagne
- Céline Keime
- Gerard Gradwohl
- Stefan Offermanns
- Thue W. Schwartz
Molecular metabolism ; Volume: 51
Article in a journal
Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine
- Hui Joyce Li
- Subir Ray
- Alper Kucukural
- Gerard Gradwohl
- Andrew Leiter
Cellular and Molecular Gastroenterology and Hepatology ; Volume: 11 ; Page: 433-448
2020
Article in a journal
Ascl1 is required to specify a subset of ventromedial hypothalamic neurons
- Shaghayegh Aslanpour
- Jessica M Rosin
- Anjali Balakrishnan
- Natalia Klenin
- Florence Blot
- Gerard Gradwohl
- Carol Schuurmans
- Deborah M Kurrasch
Development (Cambridge, England) ; Volume: 147 ; Page: dev180067
2019
Article in a journal
Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production
- Julie Piccand
- Constance Vagne
- Florence Blot
- Aline Meunier
- Anthony Beucher
- Perrine Strasser
- Mari Lund
- Sabitri Ghimire
- Laure Nivlet
- Céline Lapp
- Natalia Petersen
- Maja Engelstoft
- Christelle Thibault-Carpentier
- Céline Keime
- Sara Jimenez Correa
- Valérie Schreiber
- Nacho Molina
- Thue Schwartz
- Adèle de Arcangelis
- Gérard Gradwohl
Molecular metabolism ; Volume: 29 ; Page: 24-39
Article in a journal
A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas
- Léon van Gurp
- Mauro Muraro
- Tim Dielen
- Lina Seneby
- Gitanjali Dharmadhikari
- Gérard Gradwohl
- Alexander van Oudenaarden
- Eelco de Koning
Development (Cambridge, England) ; Volume: 146 ; Page: dev173716