Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
Team Leader : Yann HERAULT
Department : Translational medecine and neurogenetics
Yann HERAULT
Researcher
yann.herault@igbmc.fr
Research team(s)
Research subgroup(s)
Publications
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2015
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Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration
- Aline Dubos
- Anna Castells-Nobau
- Hamid Meziane
- Merel A.W. Oortveld
- Xander Houbaert
- Giovanni Iacono
- Christelle Martin
- Christophe Mittelhaeuser
- Valérie Lalanne
- Jamie M. Kramer
- Anuradha Bhukel
- Christine Quentin
- Jan Slabbert
- Patrik Verstreken
- Stefan J. Sigrist
- Nadia Messaddeq
- Marie-Christine Birling
- Mohammed Selloum
- Henk G. Stunnenberg
- Yann Humeau
- ...
Human Molecular Genetics ; Volume: 24 ; Page: 6736--6755
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Dosage of the Abcg1-U2af1 Region Modifies Locomotor and Cognitive Deficits Observed in the Tc1 Mouse Model of Down Syndrome
- Damien Marechal
- Patricia Lopes Pereira
- Arnaud Duchon
- Yann Herault
PLoS ONE ; Volume: 10 ; Page: e0115302
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Deletion of the App-Runx1 region in mice models human partial monosomy 21
- Thomas Arbogast
- Matthieu Raveau
- Claire Chevalier
- Valérie Nalesso
- Doulaye Dembele
- Hugues Jacobs
- Olivia Wendling
- Michel J. Roux
- Arnaud Duchon
- Yann Hérault
Disease Models & Mechanisms ; Volume: 8 ; Page: 623-634
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2014
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Heterozygous deletion of the Williams–Beuren syndrome critical interval in mice recapitulates most features of the human disorder
- Maria Segura-Puimedon
- Ignasi Sahún
- Emilie Velot
- Pierre Dubus
- Cristina Borralleras
- Ana Rodrigues
- Maria Adela Valero
- Olga Valverde
- Nuno Sousa
- Yann Hérault
- Mara Dierssen
- Luis Pérez-Jurado
- Victoria Campuzano
Human Molecular Genetics ; Volume: 23 ; Page: 6481-6494
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Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage
- Benoît Souchet
- Fayçal Guedj
- Ignasi Sahún
- Arnaud Duchon
- Fabrice Daubigney
- Anne Badel
- Yuchio Yanagawa
- Maria-Jose Barallobre
- Mara Dierssen
- Eugene Yu
- Yann Hérault
- Mariona Arbones
- Nathalie Janel
- Nicole Créau
- Jean-Maurice Delabar
Neurobiology of Disease ; Volume: 69 ; Page: 65-75
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Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance
- Latif Rachdi
- Dulanjalee Kariyawasam
- Virginie Aïello
- Yann Hérault
- Nathalie Janel
- Jean-Maurice Delabar
- Michel Polak
- Raphaël Scharfmann
Cell Cycle ; Volume: 13 ; Page: 2221-2229
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Domains of genome-wide gene expression dysregulation in Down’s syndrome
- Audrey Letourneau
- Federico Santoni
- Ximena Bonilla
- M. Reza Sailani
- David Gonzalez
- Jop Kind
- Claire Chevalier
- Robert Thurman
- Richard Sandstrom
- Youssef Hibaoui
- Marco Garieri
- Konstantin Popadin
- Emilie Falconnet
- Maryline Gagnebin
- Corinne Gehrig
- Anne Vannier
- Michel Guipponi
- Laurent Farinelli
- Daniel Robyr
- Eugenia Migliavacca
- ...
Nature ; Volume: 508 ; Page: 345-350
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Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome.
- François Mouton-Liger
- Ignasi Sahún
- Thibault Collin
- Patricia Lopes Pereira
- Debora Masini
- Sophie Thomas
- Evelyne Paly
- Sabrina Luilier
- Sandra Même
- Quentin Jouhault
- Soumia Bennaï
- Jean-Claude Beloeil
- Jean-Charles Bizot
- Yann Hérault
- Mara Dierssen
- Nicole Créau
Neurobiology of Disease ; Volume: 63 ; Page: 92-106
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Skin Progenitor Cells Contribute to Bleomycin-Induced Skin Fibrosis
- Shangxi Liu
- Yann Hérault
- Guillaume Pavlovic
- Andrew Leask
Arthritis & rheumatology ; Volume: 66 ; Page: 707--713
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In vivo 9.4T MRI and 1H MRS for Evaluation of Brain Structural and Metabolic Changes in the Ts65Dn Mouse Model for Down Syndrome.
- S. Même
- N. Joudiou
- N. Yousfi
- F. Szeremeta
- P. Lopes-Pereira
- J. C. Beloeil
- Y. Herault
- W. Même
World Journal of Neuroscience ; Volume: 04 ; Page: 152-163
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