Congratulations to Guillaume CAULIER on the acceptance of his thesis!
His work, supervised by Fabienne Mauxion and Bertrand Séraphin,
is entitled: Characterization of a module of the CCR4-NOT complex targeting mRNAs encoding potentially deleterious proteins.
Summary of his research:
Cells control the synthesis of aberrant or toxic proteins, particularly when they are in excess, through mechanisms recently uncovered such as co-translational mRNA degradation. Malfunctions in these quality control systems can contribute to proteinopathies and cancers. In the yeast S. cerevisiae, Caf130, interacting with Btt1 from the NAC complex, controls the degradation of the mRNA encoding the Rpl4 protein when the latter is misfolded. Structural and functional analyses, including AlphaFold modeling, helped elucidate the organization of these factors in connection with the CCR4-NOT deadenylase complex and provided a better understanding of how this model system operates.
Skills acquired at IGBMC:
Experimental skills, notably in protein purification, structural analysis, molecular biology, as well as yeast genetics. Also, skills in presenting my work, the ability to take on the challenge of progressing independently in a project, and perseverance in problem-solving.
Life at IGBMC:
The wide range of platforms available at IGBMC is a real asset for advancing our projects.
What you did not like and what should be improved:
Mutual assistance and communication between teams.
Collaborations:
Elena Conti (Max Planck Institute, Germany)
Funding and partners:
Initial funding by the University of Strasbourg, then by the ANR.
Partners for training, etc.: IMCBio, LabexINRT.
Future projects:
To undertake a postdoctoral fellowship to continue expanding my research knowledge.