Congratulations to Nicolas Zinter on the acceptance of his thesis!
Congratulations to Nicolas Zinter for the acceptance of his thesis! His work was directed by Wojciech Krezel and entitled: " Multi-level analyses of Retinoic Acid Receptor beta (RARB) signaling to understand and treat rare and progressive neurological disorders".
During his thesis, Nicolas Zinter identified the first postnatal function of RARB in the brain. In order to do that, with IGBMC platforms, the PhD student used mouse models recapitulating neurological pathologies (such as Huntington’s disease and MCOPS12) and was able to launch behavioral phenotyping as well as cellular and molecular analyses. Thus, Nicolas Zinter was able to provide a better understanding of the impact of the RARB signaling deregulation on rare and progressive neurological disorders associated to striatal cell dysfunctions and death.
Want to know more ? You can read this article published in Progress in Neurobiology : https://doi.org/10.1016/j.pneurobio.2022.102246
During his time at the IGBMC, the PhD student gained valuable knowledge in behavioral phenotyping of animal models and primary striatal cultures. Also, he won a prize as the 2nd best poster presentation during 2023 Doctoral school days.
Nicolas Zinter wanted to address many thanks to IGBMC platforms for their support ! For his thesis, he collaborated with our photonic microscopy platform and our Genomeast platform to study the loss of function of RARB in the context of Huntington’s disease and MCOPS12. He also collaborated with ICS’ platforms for the production of the different mouse models.
Thanks to the Cure MCOPS12 association for their support of this research!
Nicolas Zinter is now looking for a new position as a post-doctoral fellow in neurosciences. More specifically, he’s looking to study the neurodevelopmental aspect of neurodegenerative disorders in a lab using organoids and assembloids!