Patient-derived organoids as tools for basic and translational research in urological cancers

Le April 19 2023 at 11h00 Séminaire

Progress in cancer research has long been hampered by a lack of in vitro models that adequately reflect the molecular, cellular, and architectural complexity characterizing solid tumors. Recent technical advances have enabled the establishment of more physiologically relevant three-dimensional in vitro models derived from patient’ material and referred to as patient-derived organoids (PDOs). I will present an overview of our efforts to develop prostate cancer and bladder cancer PDOs; this will include their application to investigate drug response and drug resistance mechanisms in prostate cancer, as well as their use to decipher mechanisms driving cellular plasticity and tumor progression in bladder cancer.