POST DOC

The candidate will join the Keyes lab – Common Mechanisms of Development, Cancer and Aging, part of the Development and Stem Cells department in the IGBMC. You will benefit from an international and diverse scientific atmosphere, as well as state-of-the-art facilities including genomics, proteomics, microscopy, flow cytometry and animal facilities. The position is funded for up to 2 years from Fondation Recherche Alzheimer. Located on the southern edge of Strasbourg, France, the IGBMC (https://www.igbmc.fr/en/) and the city combine a world-class research environment with an outstanding quality of life, offering a unique setting for postdoctoral training.

Activities

Ageing is accompanied by both increased senescent cell burden and the accumulation of pathological amyloids, yet a causal relationship between these processes remains unclear. This project will dissect how senescence-associated cellular states influence amyloidogenic pathways using a broad toolkit spanning cell culture systems, protein and amyloid biochemistry, mass spectrometry-based analyses, molecular biology and mouse models. Collaborative opportunities will be encouraged across ageing, biochemistry and structural biology groups.

• Conduct original research uncovering mechanistic interactions between senescence and amyloid formation.
• Design and perform experiments using biochemical, molecular, cellular, and eventually, in vivo approaches.
• Analyse and interpret data, ensuring rigorous and reproducible research practice.
• Present findings at lab meetings, conferences, and in peer-reviewed publications.
• Contribute to mentorship of junior researchers and collaborative project development.

Technical skills

Requirements

• PhD (or near completion) in biochemistry, cell biology, molecular biology, ageing biology, or a related field.
• Strong research background in protein biochemistry, cellular or molecular biology, amyloid biology or proteostasis would be beneficial. Experience with Mass Spec and microscopy would be a plus. Experience in senescence biology or working with animal models is not needed, but a strong interest in exploiting these is required.
• Demonstrated ability to design and execute experiments and publish high-quality research.
• Effective communication, teamwork, and organizational skills. The working language of the lab is English, so good communication skills in English are required.