Postdoctoral researcher position in Functional Genomics

We are seeking a highly motivated and enthusiastic individual to join the “Genomic and epigenomic regulation of cell fate” research group. Our overall aim is to better understand how cellular identity is determined by macromolecules acting on chromatin such as transcription factors and epigenetic regulators, both in physiological and pathological conditions.

Reference
POST DOC - R.PANTIER

Contract type
POST-DOC

Publication date
11/28/2025

In the context of a project funded by the French Research Agency (ANR), you will characterise a potential new class of transcriptional regulators sensing A/T nucleotide content of target genes. Specifically, you will be in charge of designing and executing high-throughput screens in cellular models using two independent approaches based on proteomics (DNA pulldown/mass spectrometry) or CRISPR/Cas9 perturbation coupled with singe-cell transcriptomics (Perturb-seq). Promising hits identified in these screens will be further characterized at the molecular and cellular levels using genetic engineering, biochemical and phenotypic assays.

The laboratory is part of the Functional Genomics & Cancer department within the Institute of Genetics and Molecular and Cellular Biology (IGBMC). You will benefit from an international and diverse scientific environment, as well as state-of-the-art facilities including genomics, bioinformatics, proteomics, microscopy, flow cytometry and cell culture.

Relevant publications:

Chhatbar et al., bioRxiv (2025): https://doi.org/10.1101/2025.11.14.688441
Watson*, Pantier* et al., Life Sci Alliance (2023) https://doi.org/10.26508/lsa.202201588
Pantier et al., Mol Cell (2021): https://doi.org/10.1016/j.molcel.2020.11.046

Application procedures

The position is available from March 2026 (starting date to be negotiated with the selected candidate). Interviews are expected mid-January.

Applications including CV (1), cover letter (2), and contact details of at least two referees who are familiar with your scientific work (3) should be sent by email directly to Raphaël Pantier (pantierr@igbmc.fr). Candidates can also contact the laboratory for additional information regarding the research project.

Application deadline: 5^th January 2026

Related to :

Research team(s) : Genomic and epigenomic regulation of cell fate

Profil

Candidate profile

- Recently obtained PhD in genomics, molecular biology or other relevant discipline.

- Strong interest in gene regulation and chromatin biology.

- Proven experience in generating high-throughput sequencing libraries (e.g. RNA-seq, ChIP-seq).

- Good handling of standard molecular biology techniques including molecular cloning, pulldown assays, Western-blot analysis.

- Experience in CRISPR/Cas9 genetic engineering (optional, but would be a plus).

- Experience in (stem) cell culture (optional, but would be a plus).

- Experience in preparation of proteomics samples (optional, but would be a plus).

Position: Postdoctoral researcher.

Initially for 1 year, renewable.