Molecular mechanisms of chromatin reorganization

Publications

• 2022

  • Article in a journal

    Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

    • Salma Darwish
    • Ehab Ghazy
    • Tino Heimburg
    • Daniel Herp
    • Patrik Zeyen
    • Rabia Salem-Altintas
    • Johannes Ridinger
    • Dina Robaa
    • Karin Schmidtkunz
    • Frank Erdmann
    • Matthias Schmidt
    • Christophe Romier
    • Manfred Jung
    • Ina Oehme
    • Wolfgang Sippl

    International Journal of Molecular Sciences ; Volume: 23

    HAL DOI

  • Article in a journal

    Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in Trypanosoma cruzi

    • Gisele Fernanda Assine Picchi-Constante
    • Priscila Mazzocchi Hiraiwa
    • Martin Marek
    • Vanessa Zulkievicz Rogerio
    • Eloise Pavão Guerra-Slompo
    • Christophe Romier
    • Nilson Ivo Tonin Zanchin

    STAR Protocols ; Volume: 3

    HAL DOI

  • Article in a journal

    Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells

    • Patrik Zeyen
    • Yanira Zeyn
    • Daniel Herp
    • Fereshteh Mahmoudi
    • Talha Z. Yesiloglu
    • Frank Erdmann
    • Matthias Schmidt
    • Dina Robaa
    • Christophe Romie
    • Johannes Ridinger
    • Corey J. Herbst-Gervasoni
    • David W. Christianson
    • Ina Oehme
    • Manfred Jung
    • Oliver H. Krämer
    • Wolfgang Sippl

    European Journal of Medicinal Chemistry ; Volume: 234

    HAL DOI

• 2021

  • Article in a journal

    Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

    • Martin Marek
    • Elizabeth Ramos-Morales
    • Gisele F A Picchi-Constante
    • Theresa Bayer
    • Carina Norström
    • Daniel Herp
    • Policarpo A Sales-Junior
    • Eloise P Guerra-Slompo
    • Kristin Hausmann
    • Alokta Chakrabarti
    • Tajith B Shaik
    • Annika Merz
    • Edouard Troesch
    • Karin Schmidtkunz
    • Samuel Goldenberg
    • Raymond J Pierce
    • Marina M Mourão
    • Manfred Jung
    • Johan Schultz
    • Wolfgang Sippl
    • ...

    Cell Reports ; Volume: 37

    HAL DOI

  • Article in a journal

    The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination

    • Elizabeth Ramos Morales
    • Efil Bayam
    • Jordi del Pozo Rodriguez
    • Thalia Salinas-Giegé
    • Martin Marek
    • Peggy Tilly
    • Philippe Wolff
    • Edouard Troesch
    • Eric Ennifar
    • Laurence Drouard
    • Juliette Godin
    • Christophe Romier

    Nucleic Acids Research ; Volume: 49 ; Page: 6529-6548

    HAL DOI

  • Article in a journal

    Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 (smHDAC8) Inhibitors

    • Conrad V. Simoben
    • Ehab Ghazy
    • Patrick Zeyen
    • Salma Darwish
    • Matthias Schmidt
    • Christophe Romier
    • Dina Robaa
    • Wolfgang Sippl

    Molecules ; Volume: 26

    HAL DOI

  • Article in a journal

    Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation

    • Sébastien Coassolo
    • Guillaume Davidson
    • Luc Negroni
    • Giovanni Gambi
    • Sylvain Daujat
    • Christophe Romier
    • Irwin Davidson

    Nature Communications ; Volume: 12

    HAL DOI

  • Article in a journal

    Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity

    • Hany S. Ibrahim
    • Mohamed Abdelsalam
    • Yanira Zeyn
    • Mathes Zessin
    • Al-Hassan Mustafa
    • Marten A. Fischer
    • Patrik Zeyen
    • Ping Sun
    • Emre F. Bulbul
    • Anita Vecchio
    • Frank Erdmann
    • Matthias Schmidt
    • Dina Robaa
    • Cyril Barinka
    • Christophe Romier
    • Mike Schutkowski
    • Oliver H. Kramer
    • Wolfgang Sippl

    International Journal of Molecular Sciences ; Volume: 23 ; Page: 369

    HAL DOI

• 2020

  • Article in a journal

    Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

    • Ehab Ghazy
    • Patrik Zeyen
    • Daniel Herp
    • Martin Hügle
    • Karin Schmidtkunz
    • Frank Erdmann
    • Dina Robaa
    • Matthias Schmidt
    • Elizabeth Morales
    • Christophe Romier
    • Stefan Günther
    • Manfred Jung
    • Wolfgang Sippl

    European Journal of Medicinal Chemistry ; Volume: 200 ; Page: 112338

    HAL DOI

• 2019

  • Article in a journal

    Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors

    • Dmitrii V. Kalinin
    • Sunit K. Jana
    • Maxim Pfafenrot
    • Alokta Chakrabarti
    • Jelena Melesina
    • Tajith B. Shaik
    • Julien Lancelot
    • Raymond J. Pierce
    • Wolfgang Sippl
    • Christophe Romier
    • Manfred Jung
    • Ralph Holl

    ChemMedChem ; Volume: 15 ; Page: 571-584

    HAL DOI