Molecular mechanisms of chromatin reorganization

Publications

• 2024

  • The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains

    • Marina Vitoria Gomes
    • Pauline Landwerlin
    • Marie-Laure Diebold-Durand
    • Tajith B Shaik
    • Alexandre Durand
    • Edouard Troesch
    • Chantal Weber
    • Karl Brillet
    • Marianne V Lemée
    • Christophe Decroos
    • Ludivine Dulac
    • Pierre Antony
    • Erwan Watrin
    • Eric Ennifar
    • Christelle Golzio
    • Christophe Romier

    Cell Reports ; Volume: 43 ; Page: 114656

    HAL DOI

• 2023

  • Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation

    • Laura Sinatra
    • Anja Vogelmann
    • Florian Friedrich
    • Margarita A. Tararina
    • Emilia Neuwirt
    • Arianna Colcerasa
    • Philipp König
    • Lara Toy
    • Talha Z. Yesiloglu
    • Sebastian Hilscher
    • Lena Gaitzsch
    • Niklas Papenkordt
    • Shiyang Zhai
    • Lin Zhang
    • Christophe Romier
    • Oliver Einsle
    • Wolfgang Sippl
    • Mike Schutkowski
    • Olaf Gross
    • Gerd Bendas
    • ...

    Journal of Medicinal Chemistry ; Volume: 66 ; Page: 14787-14814

    HAL DOI

  • Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras

    • Salma Darwish
    • Tino Heimburg
    • Johannes Ridinger
    • Daniel Herp
    • Matthias Schmidt
    • Christophe Romier
    • Manfred Jung
    • Ina Oehme
    • Wolfgang Sippl

    HDAC/HAT Function Assessment and Inhibitor Development ; Volume: 2589 ; Page: 179-193

    HAL DOI

  • Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages

    • Beatrice Noce
    • Elisabetta Di Bello
    • Clemens Zwergel
    • Rossella Fioravanti
    • Sergio Valente
    • Dante Rotili
    • Andrea Masotti
    • Mohammad Salik Zeya Ansari
    • Daniela Trisciuoglio
    • Alokta Chakrabarti
    • Christophe Romier
    • Dina Robaa
    • Wolfgang Sippl
    • Manfred Jung
    • Cécile Häberli
    • Jennifer Keiser
    • Antonello Mai

    ChemMedChem ; Volume: 18

    HAL DOI

  • In cellulo and in vivo assays for compound testing against Trypanosoma cruzi

    • Eloise Pavão Guerra-Slompo
    • Gisele Fernanda Assine Picchi-Constante
    • Martin Marek
    • Christophe Romier
    • Wolfgang Sippl
    • Nilson Ivo Tonin Zanchin

    STAR Protocols ; Volume: 4 ; Page: 102058

    HAL DOI

• 2022

  • Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties

    • Ping Sun
    • Jing Wang
    • Khadija S. Khan
    • Weiqin Yang
    • Billy Wai-Lung Ng
    • Nikita Ilment
    • Matthes Zessin
    • Emre F. Bülbül
    • Dina Robaa
    • Frank Erdmann
    • Matthias Schmidt
    • Christophe Romier
    • Mike Schutkowski
    • Alfred Sze-Lok Cheng
    • Wolfgang Sippl

    Journal of Medicinal Chemistry ; Volume: 65 ; Page: 16313-16337

    HAL DOI

  • Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni

    • Muhammad Murtaza Hassan
    • Abootaleb Sedighi
    • Olasunkanmi O. Olaoye
    • Cécile Häberli
    • Annika Merz
    • Elizabeth Ramos Morales
    • Elvin D. de Araujo
    • Christophe Romier
    • Manfred Jung
    • Jennifer Keiser
    • Patrick T. Gunning

    ChemMedChem ; Volume: 17

    HAL DOI

  • First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement

    • Daniel Herp
    • Johannes Ridinger
    • Dina Robaa
    • Stephen A. Shinsky
    • Karin Schmidtkunz
    • Talha Z. Yesiloglu
    • Theresa Bayer
    • Raphael R. Steimbach
    • Corey J. Herbst-Gervasoni
    • Annika Merz
    • Christophe Romier
    • Peter Sehr
    • Nikolas Gunkel
    • Aubry K. Miller
    • David W. Christianson
    • Ina Oehme
    • Wolfgang Sippl
    • Manfred Jung

    ChemBioChem ; Volume: 23

    HAL DOI

  • Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

    • Salma Darwish
    • Ehab Ghazy
    • Tino Heimburg
    • Daniel Herp
    • Patrik Zeyen
    • Rabia Salem-Altintas
    • Johannes Ridinger
    • Dina Robaa
    • Karin Schmidtkunz
    • Frank Erdmann
    • Matthias Schmidt
    • Christophe Romier
    • Manfred Jung
    • Ina Oehme
    • Wolfgang Sippl

    International Journal of Molecular Sciences ; Volume: 23

    HAL DOI

  • Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in Trypanosoma cruzi

    • Gisele Fernanda Assine Picchi-Constante
    • Priscila Mazzocchi Hiraiwa
    • Martin Marek
    • Vanessa Zulkievicz Rogerio
    • Eloise Pavão Guerra-Slompo
    • Christophe Romier
    • Nilson Ivo Tonin Zanchin

    STAR Protocols ; Volume: 3

    HAL DOI