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Structure-fonction of nucleoproteic complexes of DNA topoisomerases

Structure-fonction of nucleoproteic complexes of DNA topoisomerases

SUBGROUP LEADER

Valerie LAMOUR

Our project is aiming at the functional and structural studies of DNA topoisomerase cellular complexes targeted by therapeutic compounds used in cancer and anti-bacterial therapies. The main goal of this study is to identify and study the structure/function of Topoisomerase-associated complexes targeted by drugs through a combination of functional and structural approaches.

Current projects

Structural analysis of chromatin complexes of human DNA topoisomerases (TopoII).

Impact of post-translational modifications on the catalytic activities of the human Topo II isoforms.

Structure/function analysis of nucleoproteic complexes of the bacterial DNA gyrase.

Publications