Integrated Structural Biology
Leader : Catherine BIRCK
Alastair MC EWEN
Engineer
alastair@igbmc.fr
Platform(s) / Service(s)
Research platforms
Publications
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2025
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Article in a journal
The Holdup Multiplex, an assay for high-throughput measurement of protein-ligand affinity constants using a mass-spectrometry readout
- François Delalande
- So̷ren Østergaard
- Gergő Gógl
- Alexandra Cousido-Siah
- Alastair G Mcewen
- Yushi Men
- Farida Salimova
- Aurélien Rohrbacher
- Camille Kostmann
- Yves Nominé
- Renaud Vincentelli
- Pascal Eberling
- Christine Carapito
- Gilles Travé
- Elodie Monsellier
Journal of the American Chemical Society ; Volume: 147 ; Page: 10886-10902
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2024
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Article in a journal
Molecular mechanism of IKK catalytic dimer docking to NF-κB substrates
- Changqing Li
- Stefano Moro
- Kateryna Shostak
- Francis J O’reilly
- Mariel Donzeau
- Andrea Graziadei
- Alastair G Mcewen
- Dominique Desplancq
- Pierre Poussin-Courmontagne
- Thomas Bachelart
- Mert Fiskin
- Nicolas Berrodier
- Simon Pichard
- Karl Brillet
- Georges Orfanoudakis
- Arnaud Poterszman
- Vladimir Torbeev
- Juri Rappsilber
- Norman E Davey
- Alain Chariot
- ...
Nature Communications ; Volume: 15 ; Page: 7692
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2023
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Article in a journal
Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA
- Abdul Kareem Mohideen Patel
- Pierre Vilela
- Tajith Baba Shaik
- Alastair G Mcewen
- Isabelle Hazemann
- Karl Brillet
- Eric Ennifar
- Ali Hamiche
- Gabriel V Markov
- Vincent Laudet
- Dino Moras
- Bruno P Klaholz
- Isabelle M Billas
Nucleic Acids Research ; Volume: 51 ; Page: 8864-8879
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Article in a journal
Crystal Structure of Staphopain C from Staphylococcus aureus
- Malgorzata Magoch
- Alastair McEwen
- Valeria Napolitano
- Benedykt Władyka
- Grzegorz Dubin
Molecules ; Volume: 28 ; Page: 4407
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2022
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Article in a journal
A novel nuclear receptor subfamily enlightens the origin of heterodimerization
- Brice Beinsteiner
- Gabriel V Markov
- Maxime Bourguet
- Alastair G Mcewen
- Stéphane Erb
- Abdul Kareem Mohideen Patel
- Fatima Z El Khaloufi El Khaddar
- Claire Lecroisey
- Guillaume Holzer
- Karim Essabri
- Isabelle Hazemann
- Ali Hamiche
- Sarah Cianférani
- Dino Moras
- Vincent Laudet
- Isabelle M L Billas
BMC Biology ; Volume: 20 ; Page: 217
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2021
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Article in a journal
The SOUL family of heme-binding proteins: Structure and function 15 years later
- Brian J. Goodfellow
- Filipe Freire
- Ana Luisa Carvalho
- Susana S. Aveiro
- Peggy Charbonnier
- Jean Marc Moulis
- Leonildo Delgado
- Gloria C. Ferreira
- João E. Rodrigues
- Pierre Poussin-Courmontagne
- Catherine Birck
- Alastair G Mcewen
- Anjos L. Macedo
Coordination Chemistry Reviews ; Volume: 448 ; Page: 214189
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Article in a journal
A structural signature motif enlightens the origin and diversification of nuclear receptors
- Brice Beinsteiner
- Gabriel V Markov
- Stéphane Erb
- Yassmine Chebaro
- Alastair G Mcewen
- Sarah Cianférani
- Vincent Laudet
- Dino Moras
- Isabelle M L Billas
PLoS Genetics ; Volume: 17 ; Page: e1009492
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Article in a journal
Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP
- Christopher Browning
- Alastair Mcewen
- Kotaro Mori
- Taiyo Yokoi
- Dino Moras
- Yoshiaki Nakagawa
- Isabelle Billas Massobrio
Journal of Pesticide Science ; Volume: 46 ; Page: 88-100
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Article in a journal
Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site
- Elise Naudin
- Alastair G. Mcewen
- Sophia K. Tan
- Pierre Poussin-Courmontagne
- Jean Louis Schmitt
- Catherine Birck
- William F. Degrado
- Vladimir Torbeev
Journal of the American Chemical Society ; Volume: 143 ; Page: 3330-3339
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Article in a journal
A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress
- Eric Moeglin
- Dominique Desplancq
- Audrey Stoessel
- Christian Massute
- Jeremy Ranniger
- Alastair G Mcewen
- Gabrielle Zeder-Lutz
- Mustapha Oulad-Abdelghani
- Manuela Chiper
- Pierre Lafaye
- Barbara Di Ventura
- Pascal Didier
- A. Poterszman
- Etienne Weiss
Cancers ; Volume: 13 ; Page: 3317
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