Spatial organisation of the genome
Team Leader : Thomas SEXTON
Department : Functional genomics and cancer
Thomas SEXTON
Researcher
thomas.sexton@igbmc.fr
Research team(s)
Publications
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2024
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Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation
- Paul Marie
- Matéo Bazire
- Julien Ladet
- Lamya Ben Ameur
- Sanjay Chahar
- Nicolas Fontrodona
- Tom Sexton
- Didier Auboeuf
- Cyril F Bourgeois
- Franck Mortreux
Nucleic Acids Research ; Volume: 52 ; Page: 1527-1543
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Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics
- Angeliki Platania
- Cathie Erb
- Mariano Barbieri
- Bastien Molcrette
- Erwan Grandgirard
- Marit de Kort
- Wim Pomp
- Karen Meaburn
- Tiegh Taylor
- Virlana Shchuka
- Silvia Kocanova
- Mariia Nazarova
- Guilherme Monteiro Oliveira
- Jennifer Mitchell
- Evi Soutoglou
- Tineke Lenstra
- Nacho Molina
- Argyris Papantonis
- Kerstin Bystricky
- Tom Sexton
Science Advances ; Volume: 10 ; Page: eadq0987
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2023
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Transcription induces context-dependent remodeling of chromatin architecture during differentiation
- Sanjay Chahar
- Yousra Ben Zouari
- Hossein Salari
- Dominique Kobi
- Manon Maroquenne
- Cathie Erb
- Anne Molitor
- Audrey Mossler
- Nezih Karasu
- Daniel Jost
- Tom Sexton
PLoS Biology ; Volume: 21 ; Page: e3002424
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Short tandem repeats are important contributors to silencer elements in T cells
- Saadat Hussain
- Nori Sadouni
- Dominic van Essen
- Lan T M Dao
- Quentin Ferré
- Guillaume Charbonnier
- Magali Torres
- Frederic Gallardo
- Charles-Henri Lecellier
- Tom Sexton
- Simona Saccani
- Salvatore Spicuglia
Nucleic Acids Research ; Volume: 51 ; Page: 4845-4866
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Competition between transcription and loop extrusion modulates promoter and enhancer dynamics
- Angeliki Platania
- Cathie Erb
- Mariano Barbieri
- Bastien Molcrette
- Erwan Grandgirard
- Marit Ac de Kort
- Karen Meaburn
- Tiegh Taylor
- Virlana M Shchuka
- Silvia Kocanova
- Guilherme Monteiro Oliveira
- Jennifer A Mitchell
- Evi Soutoglou
- Tineke L Lenstra
- Nacho Molina
- Argyris Papantonis
- Kerstin Bystricky
- Tom Sexton
- Guilherme Monteiro Oliveira
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2022
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Context-dependent transcriptional remodeling of TADs during differentiation
- Sanjay Chahar
- Yousra Ben Zouari
- Hossein Salari
- Anne Molitor
- Dominique Kobi
- Manon Maroquenne
- Cathie Erb
- Audrey Mossler
- Nezih Karasu
- Daniel Jost
- Tom Sexton
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Concurrent CDX2 cis -deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL
- Marie Passet
- Rathana Kim
- Stéphanie Gachet
- François Sigaux
- Julie Chaumeil
- Ava Galland
- Thomas Sexton
- Samuel Quentin
- Lucie Hernandez
- Lise Larcher
- Hugo Bergugnat
- Tao Ye
- Nezih Karasu
- Aurélie Caye
- Beate Heizmann
- Isabelle Duluc
- Patrice Chevallier
- Philippe Rousselot
- Françoise Huguet
- Thibaut Leguay
- ...
Blood ; Volume: 139 ; Page: 3505-3518
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The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes
- Ludmila Recoules
- Alexandre Heurteau
- Flavien Raynal
- Nezih Karasu
- Fatima Moutahir
- Fabienne Bejjani
- Isabelle Jariel-Encontre
- Olivier Cuvier
- Thomas Sexton
- Anne-Claire Lavigne
- Kerstin Bystricky
Journal of Cell Science ; Volume: 135 ; Page: jcs259456
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2021
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Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
- Rafael Alcalá-Vida
- Jonathan Seguin
- Caroline Lotz
- Anne Molitor
- Ibai Irastorza-Azcarate
- Ali Awada
- Nezih Karasu
- Aurélie Bombardier
- Brigitte Cosquer
- Jose Luis Gomez Skarmeta
- Jean-Christophe Cassel
- Anne-Laurence Boutillier
- Thomas Sexton
- Karine Merienne
Nature Communications ; Volume: 12 ; Page: 364
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Precise measurements of chromatin diffusion dynamics by modeling using Gaussian processes
- Guilherme Oliveira
- Attila Oravecz
- Dominique Kobi
- Manon Maroquenne
- Kerstin Bystricky
- Thomas Sexton
- Nacho Molina
Nature Communications ; Volume: 12 ; Page: 6184
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