Yann HERAULT

Researcher
yann.herault@igbmc.fr

Research team(s)

Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
Team Leader : Yann HERAULT
Department : Translational medecine and neurogenetics

Research subgroup(s)

Aging, Down's syndrome and Alzheimer's disease
Leader : Yann HERAULT
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
Modeling of "genotype-phenotype" relationships and therapeutic approach in Down syndrome
Leader : Yann HERAULT
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
neurobiology of 16p11.2 and 17q21.31syndromes and other genetic diseases with ID or ASD
Leader : Yann HERAULT
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities

Publications

2022
- The Human SCN9AR185H Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice
  - Yaping Xue
  - Mélanie Kremer
  - Maria del Mar Muniz Moreno
  - Celeste Chidiac
  - Romain Lorentz
  - Marie-Christine Birling
  - Michel Barrot
  - Yann Herault
  - Claire Gaveriaux-Ruff
  Frontiers in Molecular Neuroscience ; Volume: 15 ; Page: 913990
  HAL DOI
- HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models
  - Laetitia Dard
  - Christophe Hubert
  - Pauline Esteves
  - Wendy Blanchard
  - Ghina Bou About
  - Lyla Baldasseroni
  - Elodie Dumon
  - Chloe Angelini
  - Mégane Delourme
  - Veronique Guyonnet-Duperat
  - Stephane Claverol
  - Laura Fontenille
  - Karima Kissa
  - Pierre-Emmanuel Seguela
  - Jean-Benoit Thambo
  - Nicolas Levy
  - Yann Hérault
  - Nadege Bellance
  - Nivea Dias Amoedo
  - Frédérique Magdinier
  - ...
  JOURNAL OF CLINICAL INVESTIGATION ; Volume: 132
  HAL DOI
- Possible association of 16p11.2 copy number variation with altered lymphocyte and neutrophil counts
  - Giuliana Giannuzzi
  - Nicolas Chatron
  - Katrin Mannik
  - Chiara Auwerx
  - Sylvain Pradervand
  - Gilles Willemin
  - Kendra Hoekzema
  - Xander Nuttle
  - Jacqueline Chrast
  - Marie Sadler
  - Eleonora Porcu
  - Nicolas Chatron
  - Katrin Männik
  - Damien Sanlaville
  - Caroline Schluth-Bolard
  - Cédric Le Caignec
  - Mathilde Nizon
  - Sandra Martin
  - Sébastien Jacquemont
  - Armand Bottani
  - ...
  npj Genomic Medicine ; Volume: 7 ; Page: 38
  HAL DOI
2021
- The Human SCN10AG1662S Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity
  - Céleste Chidiac
  - Yaping Xue
  - Maria del Mar Muniz Moreno
  - Ameer Abu Bakr Rasheed
  - Romain Lorentz
  - Marie-Christine Birling
  - Claire Gaveriaux-Ruff
  - Yann Herault
  Frontiers in Pharmacology ; Volume: 12 ; Page: 780132
  HAL DOI
- Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models
  - Sandra Martin Lorenzo
  - Valérie Nalesso
  - Claire Chevalier
  - Marie-Christine Birling
  - Yann Hérault
  Molecular Autism ; Volume: 12
  HAL DOI
- HDAC inhibitor ameliorates behavioral deficits in Mecp2308/y mouse model of Rett syndrome
  - Nicolas Lebrun
  - Chloé Delépine
  - Mohamed Selloum
  - Hamid Meziane
  - Juliette Nectoux
  - Yann Herault
  - Thierry Bienvenu
  Brain Research ; Volume: 1772 ; Page: 147670
  HAL DOI
- ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis
  - Alyssa Imbert
  - Magali Rompais
  - Mohammed Selloum
  - Florence Castelli
  - Emmanuelle Mouton-Barbosa
  - Marion Brandolini-Bunlon
  - Emeline Chu-Van
  - Charlotte Joly
  - Aurélie Hirschler
  - Pierrick Roger-Mele
  - Thomas Burger
  - Sophie Leblanc
  - Tania Sorg
  - Sadia Ouzia
  - Yves Vandenbrouck
  - Claudine Médigue
  - Christophe Junot
  - Myriam Ferro
  - Christine Carapito
  - Anne Gonzalez de Peredo
  - ...
  Scientific Data ; Volume: 8 ; Page: 311
  HAL DOI
- Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome
  - Helin Atas-Ozcan
  - Véronique Brault
  - Arnaud Duchon
  - Yann Hérault
  Genes ; Volume: 12 ; Page: 1833
  HAL DOI
- Integrative approach to interpret DYRK1A variants, leading to a frequent neurodevelopmental disorder
  - Jérémie Courraud
  - Eric Chater-Diehl
  - Benjamin Durand
  - Marie Vincent
  - Maria del Mar Muñiz Moreno
  - Imène Boujelbene
  - Nathalie Drouot
  - Lauréline Genschik
  - Elise Schaefer
  - Mathilde Nizon
  - Bénédicte Gerard
  - Marc Abramowicz
  - Benjamin Cogné
  - Lucas Bronicki
  - Lydie Burglen
  - Magalie Barth
  - Perrine Charles
  - Estelle Colin
  - Christine Coubes
  - Albert David
  - ...
  Genetics in Medicine ; Volume: 23 ; Page: 2150–2159
  HAL DOI
- Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
  - Véronique Brault
  - Thu Lan Nguyen
  - Javier Flores-Gutiérrez
  - Giovanni Iacono
  - Marie-Christine Birling
  - Valérie Lalanne
  - Hamid Meziane
  - Antigoni Manousopoulou
  - Guillaume Pavlovic
  - Loïc Lindner
  - Mohammed Selloum
  - Tania Sorg
  - Eugene Yu
  - Spiros D Garbis
  - Yann Hérault
  PLoS Genetics ; Volume: 17 ; Page: e1009777
  HAL DOI

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Yann HERAULT

Research team(s)

Research subgroup(s)

Publications

2022

2021