Christophe ROMIER

Publications

• 2019

  • Article in a journal

    Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors

    • Dmitrii V. Kalinin
    • Sunit K. Jana
    • Maxim Pfafenrot
    • Alokta Chakrabarti
    • Jelena Melesina
    • Tajith B. Shaik
    • Julien Lancelot
    • Raymond J. Pierce
    • Wolfgang Sippl
    • Christophe Romier
    • Manfred Jung
    • Ralph Holl

    ChemMedChem ; Volume: 15 ; Page: 571-584

    HAL DOI

  • Article in a journal

    One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

    • Matthes Zessin
    • Zsófia Kutil
    • Marat Meleshin
    • Zora Nováková
    • Ehab Ghazy
    • Diana Kalbas
    • Martin Marek
    • Christophe Romier
    • Wolfgang Sippl
    • Cyril Bařinka
    • Mike Schutkowski

    Biochemistry ; Volume: 58 ; Page: 4777-4789

    HAL DOI

  • Article in a journal

    Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni ( Sm Sirt2)

    • Daria Monaldi
    • Dante Rotili
    • Julien Lancelot
    • Martin Marek
    • Nathalie Wössner
    • Alessia Lucidi
    • Daniela Tomaselli
    • Elizabeth Ramos-Morales
    • Christophe Romier
    • Raymond J. Pierce
    • Antonello Mai
    • Manfred Jung

    Journal of Medicinal Chemistry ; Volume: 62 ; Page: 8733-8759

    HAL DOI

  • Article in a journal

    Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

    • Katharina Vögerl
    • Nghia Ong
    • Johanna Senger
    • Daniel Herp
    • Karin Schmidtkunz
    • Martin Marek
    • Martin Müller
    • Karin Bartel
    • Tajith Shaik
    • Nicholas Porter
    • Dina Robaa
    • David W. Christianson
    • Christophe Romier
    • Wolfgang Sippl
    • Manfred Jung
    • Franz Bracher

    Journal of Medicinal Chemistry ; Volume: 62 ; Page: 1138-1166

    HAL DOI

• 2018

  • Article in a journal

    Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

    • Martin Marek
    • Tajith Shaik
    • Tino Heimburg
    • Alokta Chakrabarti
    • Julien Lancelot
    • Elizabeth Ramos-Morales
    • Cyrielle da Veiga
    • Dmitrii Kalinin
    • Jelena Melesina
    • Dina Robaa
    • Karin Schmidtkunz
    • Takayoshi Suzuki
    • Ralph Holl
    • Eric Ennifar
    • Raymond Pierce
    • Manfred Jung
    • Wolfang Sippl
    • Christophe Romier

    Journal of Medicinal Chemistry ; Volume: 61 ; Page: 10000-10016

    HAL DOI

  • Article in a journal

    Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies

    • Margherita Brindisi
    • Johanna Senger
    • Caterina Cavella
    • Alessandro Grillo
    • Giulia Chemi
    • Sandra Gemma
    • Dora Mariagrazia Cucinella
    • Stefania Lamponi
    • Federica Sarno
    • Concetta Iside
    • Angela Nebbioso
    • Ettore Novellino
    • Tajith Baba Shaik
    • Christophe Romier
    • Daniel Herp
    • Manfred Jung
    • Stefania Butini
    • Giuseppe Campiani
    • Lucia Altucci
    • Simone Brogi

    European Journal of Medicinal Chemistry ; Volume: 157 ; Page: 127-138

    HAL DOI

  • Article in a journal

    Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

    • Bertrand Lecointre
    • Remy Narozny
    • Maria Teresa Borrello
    • Johanna Senger
    • Alokta Chakrabarti
    • Manfred Jung
    • Martin Marek
    • Christophe Romier
    • Jelena Melesina
    • Wolfgang Sippl
    • Laurent Bischoff
    • A. Ganesan

    Philosophical Transactions of the Royal Society B: Biological Sciences ; Volume: 373 ; Page: 20170364

    HAL DOI

  • Article in a journal

    A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

    • Conrad Simoben
    • Dina Robaa
    • Alokta Chakrabarti
    • Karin Schmidtkunz
    • Martin Marek
    • Julien Lancelot
    • Srinivasaraghavan Kannan
    • Jelena Melesina
    • Tajith Shaik
    • Raymond J. Pierce
    • Christophe Romier
    • Manfred Jung
    • Wolfgang Sippl

    Molecules ; Volume: 23 ; Page: 566

    HAL DOI

• 2017

  • Article in a journal

    Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

    • Tino Heimburg
    • Fiona Kolbinger
    • Patrik Zeyen
    • Ehab Ghazy
    • Daniel Herp
    • Karin Schmidtkunz
    • Jelena Melesina
    • Tajith Baba Shaik
    • Frank Erdmann
    • Matthias Schmidt
    • Christophe Romier
    • Dina Robaa
    • Olaf Witt
    • Ina Oehme
    • Manfred Jung
    • Wolfgang Sippl

    Journal of Medicinal Chemistry ; Volume: 60 ; Page: 10188-10204

    HAL DOI

  • Article in a journal

    Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni

    • Leticia Anderson
    • Monete Gomes
    • Lucas Dasilva
    • Adriana da Silva Andrade Pereira
    • Marina Mourão
    • Christophe Romier
    • Raymond Pierce
    • Sergio Verjovski-Almeida

    PLoS Neglected Tropical Diseases ; Volume: 11

    HAL DOI