Regulation of gene expression in cancer
Team Leader : Irwin DAVIDSON
Department : Functional genomics and cancer
Irwin DAVIDSON
Researcher
irwin@igbmc.fr
Research team(s)
Publications
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2024
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An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection.
- Atish Mukherji
- Frank Juehling
- Yogy Simanjuntak
- Emilie Crouchet
- Fabio del Zompo
- Yuji Teraoka
- Alexandre Haller
- Philippe Baltzinger
- Soumith Paritala
- Fahmida Rasha
- Naoto Fujiwara
- Cloé Gadenne
- Nevena Slovic
- Marine Oudot
- Sarah C. Durand
- Clara Ponsolles
- Catherine Schuster
- Xiaodong Zhuang
- Jacinta Holmes
- Ming-Lun Yeh
- ...
Nature Communications ; Volume: 15 ; Page: 7486
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2023
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Mesenchymal-like Tumor Cells and Myofibroblastic Cancer-Associated Fibroblasts Are Associated with Progression and Immunotherapy Response of Clear Cell Renal Cell Carcinoma
- Guillaume Davidson
- Alexandra Helleux
- Yann Vano
- Veronique Lindner
- Antonin Fattori
- Marie Cerciat
- Reza T. Elaidi
- Virginie Verkarre
- Cheng-Ming Sun
- Christine Chevreau
- Mostefa Bennamoun
- Hervé Lang
- Thibault Tricard
- Wolf H. Fridman
- Catherine Sautes-Fridman
- Xiaoping Su
- Damien Plassard
- Céline Keime
- Christelle Thibault-Carpentier
- Philippe Barthelemy
- ...
Cancer Research ; Volume: 83 ; Page: 2952-2969
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Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks
- Hélène Neyret-Kahn
- Jacqueline Fontugne
- Xiang Yu Meng
- Clarice Groeneveld
- Luc Cabel
- Tao Ye
- Elodie Guyon
- Clémentine Krucker
- Florent Dufour
- Elodie Chapeaublanc
- Audrey Rapinat
- Daniel Jeffery
- Laura Tanguy
- Victoria Dixon
- Yann Neuzillet
- Thierry Lebret
- David Gentien
- Irwin Davidson
- Yves Allory
- Isabelle Bernard-Pierrot
- ...
Oncogene ; Volume: 42 ; Page: 1524-1542
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An Enhancer Demethylator Phenotype Converged to Immune Dysfunction and Resistance to Immune Checkpoint Inhibitors in Clear-Cell Renal Cell Carcinomas
- Xiaofan Lu
- Yann Vano
- Alexandra Helleux
- Xiaoping Su
- Veronique Lindner
- Guillaume Davidson
- Roger Mouawad
- Jean-Philippe Spano
- Morgan Rouprêt
- Reza Elaidi
- Eva Compérat
- Virginie Verkarre
- Chengming Sun
- Christine Chevreau
- Mostefa Bennamoun
- Hervé Lang
- Thibault Tricard
- Wenxuan Cheng
- Li Xu
- Irwin Davidson
- ...
Clinical Cancer Research ; Volume: 29 ; Page: 1279-1291
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Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment
- Natascha Roehlen
- Marion Muller
- Zeina Nehme
- Emilie Crouchet
- Frank Jühling
- Fabio del Zompo
- Sara Cherradi
- François Ht Duong
- Nuno Almeida
- Antonio Saviano
- Mirian Fernández-Vaquero
- Tobias Riedl
- Houssein El Saghire
- Sarah C. Durand
- Clara Ponsolles
- Marine Oudot
- Romain Martin
- Nicolas Brignon
- Emanuele Felli
- Patrick Pessaux
- ...
Journal of Hepatology ; Volume: 78 ; Page: 343-355
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General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.
- Susanna Säisä-Borreill
- Guillaume Davidson
- Thomas Kleiber
- Andréa Thevenot
- Elisabeth Martin
- Stanislas Mondot
- Hervé M. Blottiere
- Alexandra Helleux
- Gabrielle Mengus
- Michelina Plateroti
- Isabelle Duluc
- Irwin Davidson
- Jean-Noël Freund
Cell death and differentiation
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Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability
- Pietro Berico
- Maguelone Nogaret
- Max Cigrang
- Antonin Lallement
- Fatemeh Vand-Rajabpour
- Amanda Flores-Yanke
- Giovanni Gambi
- Guillaume Davidson
- Leane Seno
- Jolian Obid
- Bujamin H. Vokshi
- Stéphanie Le Gras
- Gabrielle Mengus
- Tao Ye
- Carlos Fernandez Cordero
- Mélanie Dalmasso
- Emmanuel Compe
- Corine Bertolotto
- Eva Hernando
- Irwin Davidson
- ...
Cell Reports ; Volume: 42 ; Page: 113363
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2022
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A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity
- Natascha Roehlen
- Antonio Saviano
- Houssein El Saghire
- Emilie Crouchet
- Zeina Nehme
- Fabio del Zompo
- Frank Juehling
- Marine Oudot
- Sarah C. Durand
- François Ht Duong
- Sara Cherradi
- Victor Gonzalez Motos
- Nuno Almeida
- Clara Ponsolles
- Laura Heydmann
- Tessa Ostyn
- Antonin Lallement
- Patrick Pessaux
- Emanuele Felli
- Andrea Cavalli
- ...
Science Translational Medicine ; Volume: 14
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The lncRNA LENOX interacts with RAP2C to regulate metabolism and promote resistance to MAPK inhibition in melanoma.
- Giovanni Gambi
- Gabrielle Mengus
- Guillaume Davidson
- Ewout Demesmaeker
- Alessandro Cuomo
- Tiziana Bonaldi
- Vasiliki Katopodi
- Gabriel Malouf
- Eleonora Leucci
- Irwin Davidson
Cancer Research
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Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment
- Wenjin Yao
- Beatriz German
- Dounia Chraa
- Antoine Braud
- Cecile Hugel
- Pierre Meyer
- Guillaume Davidson
- Patrick Laurette
- Gabrielle Mengus
- Eric Flatter
- Pierre Marschall
- Justine Segaud
- Marine Guivarch
- Pierre Hener
- Marie-Christine Birling
- Dan Lipsker
- Irwin Davidson
- Mei Li
JCI Insight
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