Postdoctoral Research Fellow in Functional Genomics and Molecular Mechanisms of Oncogenic Transcription Factor Fusions

A fundamental question in cancer biology : How does an oncogenic transcription factor transform a normal cell into an aggressive cancer?

Oncogenic transcription factor fusions are among the most potent cancer drivers identified in human malignancies, yet the molecular principles governing their activity remain poorly understood. Why do they transform only specific cell types? How do they reprogram chromatin and transcription? How are they regulated by protein stability, post-translational modifications and cofactor interactions? Most importantly, how do these mechanisms create therapeutic vulnerabilities?