3'-5' RNA decay and effects on pathologies

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3'-5' RNA decay and effects on pathologies

SUBGROUP LEADER

While the main mRNA decay pathway involves the 5’ to 3’ degradation of the mRNA body, 3’ to 5’ exonucleolytic mRNA trimming has been shown to play a major role for the elimination of defective, poorly translatable transcripts. Factors involved in the latter pathway are altered in a rare human genetic disease, underlining its importance. In this context, we are testing the role of these factors in pathological conditions. Moreover, we have identified new factors associated with 3’-5’ mRNA decay and are actively pursuing their characterization.

Teams

Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management

Members

Researchers

Publications

2014
- Article in a journal
  
  Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast
  - Laurence Decourty
  - Antonia Doyen
  - Christophe Malabat
  - Emmanuel Frachon
  - Delphine Rispal
  - Bertrand Séraphin
  - Frank Feuerbach
  - Alain Jacquier
  - Cosmin Saveanu
  Cell Reports ; Volume: 6 ; Page: 593--598
  HAL DOI
- Article in a journal
  
  Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress
  - A van den Elzen
  - A Schuller
  - R Green
  - Bertrand Séraphin
  EMBO Journal ; Volume: 33 ; Page: 265-276
  HAL DOI
- Article in a journal
  
  Quantification of pre-mRNA escape rate and synergy in splicing
  - Marie Mi Bonde
  - S Voegeli
  - A Baudrimont
  - Bertrand Séraphin
  - A Becskei
  Nucleic Acids Research ; Volume: 42 ; Page: 12847-12860
  HAL DOI
- Article in a journal
  
  A novel protein-protein interaction in the RES (REtention and Splicing) complex
  - K Tripsianes
  - A Friberg
  - C Barrandon
  - M Brooks
  - H van Tilbeurgh
  - Bertrand Séraphin
  - M Sattler
  Journal of Biological Chemistry ; Volume: 289 ; Page: 28640-28650
  HAL DOI
2013
- Article in a journal
  
  Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay.
  - Olga Kolesnikova
  - Régis Back
  - Marc Graille
  - Bertrand Séraphin
  Nucleic Acids Research ; Volume: 41 ; Page: 9514-9523
  HAL DOI
- Article in a journal
  
  Rapid screening of yeast mutants with reporters identifies new splicing phenotypes
  - Natacha Dreumont
  - Bertrand Séraphin
  FEBS Journal ; Volume: 280 ; Page: 2712-2726
  HAL DOI
- Article in a journal
  
  Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex
  - V Bhaskar
  - Vladimir Roudko
  - J Basquin
  - K Sharma
  - H Urlaub
  - Bertrand Séraphin
  - E Conti
  Nature Structural and Molecular Biology ; Volume: 20 ; Page: 1281-1288
  HAL DOI
- Article in a journal
  
  Intracellular ribonucleases involved in transcript processing and decay: precision tools for RNA
  - C Arraiano
  - Fabienne Mauxion
  - S Viegas
  - R Matos
  - Bertrand Séraphin
  BBA - Biochimica et Biophysica Acta ; Volume: 1829 ; Page: 491-513
  HAL DOI
- Article in a journal
  
  C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex
  - Fabienne Mauxion
  - Brigitte Prève
  - Bertrand Séraphin
  RNA Biology ; Volume: 10 ; Page: 267-276
  HAL DOI
2012
- Article in a journal
  
  Extensive degradation of RNA precursors by the exosome in wild-type cells.
  - Rajani Kanth Gudipati
  - Zhenyu Xu
  - Alice Lebreton
  - Bertrand Séraphin
  - Lars M Steinmetz
  - Alain Jacquier
  - Domenico Libri
  Molecular Cell ; Volume: 48 ; Page: 409-21
  HAL DOI

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3'-5' RNA decay and effects on pathologies