Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Functional genomics and cancer
Bertrand SERAPHIN
Researcher
seraphin@igbmc.fr
Research team(s)
Research subgroup(s)
Publications
2021
A conserved motif in human BTG1 and BTG2 proteins mediates interaction with the poly(A) binding protein PABPC1 to stimulate mRNA deadenylation
- Hamza Amine
- Nina Ripin
- Sahil Sharma
- Georg Stoecklin
- Frédéric Allain
- Bertrand Séraphin
- Fabienne Mauxion
RNA Biology ; Page: 1-16
2020
Pby1 is a direct partner of the Dcp2 decapping enzyme
- Clément Charenton
- Claudine Gaudon-Plesse
- Régis Back
- Nathalie Ulryck
- Loreline Cosson
- Bertrand Séraphin
- Marc Graille
Nucleic Acids Research ; Volume: 48
2019
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation
- Amy O’connell
- Maxim Gerashchenko
- Marie-Françoise O'Donohue
- Samantha Rosen
- Eric Huntzinger
- Diane Gleeson
- Antonella Galli
- Edward Ryder
- Siqi Cao
- Quinn Murphy
- Shideh Kazerounian
- Sarah Morton
- Klaus Schmitz-Abe
- Vadim Gladyshev
- Pierre-Emmanuel Gleizes
- Bertrand Séraphin
- Pankaj Agrawal
PLoS Genetics ; Volume: 15 ; Page: e1007917
2018
Recruitment of the mRNA decay machineries to the 5’ end of mRNAs
- Clément Charenton
- Claudine Gaudon Plesse
- Valério Taverniti
- Régis Back
- Bertrand Séraphin
- Marc Graille
2017
A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5′–3′ mRNA exonuclease in yeast
- Clément Charenton
- Claudine Gaudon-Plesse
- Zaineb Fourati
- Valério Taverniti
- Régis Back
- Olga Kolesnikova
- Bertrand Séraphin
- Marc Graille
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 114 ; Page: E9493-E9501
Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain
- A van Roon
- C Oubridge
- E Obayashi
- B Sposito
- A Newman
- Bertrand Séraphin
- K Nagai
RNA ; Volume: 23 ; Page: 968-981
Structures and activities of the Elongator complex and Its cofactors
- Olga Kolaj-Robin
- Bertrand Séraphin
Enzymes ; Volume: 41 ; Page: 117-149
Architecture of the yeast elongator complex
- M Dauden
- J Kosinski
- Olga Kolaj-Robin
- A Desfosses
- A Ori
- C Faux
- N Hoffmann
- O Onuma
- K Breunig
- M Beck
- C Sachse
- Bertrand Séraphin
- S Glatt
- C Muller
EMBO Reports ; Volume: 18 ; Page: 264-279
2016
Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator
- Clément Charenton
- Valerio Taverniti
- Claudine Gaudon-Plesse
- Régis Back
- Bertrand Séraphin
- Marc Graille
Nature Structural and Molecular Biology ; Volume: 23 ; Page: 982-986
Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2
- Sahil Sharma
- Fabian Poetz
- Marius Bruer
- Thi Bach Nga Ly-Hartig
- Johanna Schott
- Bertrand Séraphin
- Georg Stoecklin
Molecular Cell ; Volume: 63 ; Page: 927-38