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Eukaryotic mRNA decay

Eukaryotic mRNA decay

We are interested to unravel the mechanisms controlling eukaryotic gene expression at the level of RNA decay. Those contribute to the regulation of gene expression as changes in the local decay rate of specific messenger RNAs (mRNAs) most often result in cognate changes in the level of the corresponding protein through the modulation of the level of the mRNA template available to ribosomes. Thus, changes in mRNA degradation may affect in a timely manner the quantity of protein synthesized, but also contribute to the localized expression of specific factors (e.g., during development). Besides its quantitative role in controlling mRNA levels, RNA decay also performs a second qualitative function through the elimination of aberrant or damaged RNA molecules.


Several pathways implicated in the degradation of eukaryotic RNAs have been identified. The main pathway for the degradation of « normal » mRNAs is multistep, being initiated by the removal of the mRNA poly(A) tail, a process coined deadenylation, and usually followed by decapping before the degradation of the mRNA body in the 5’-3’ direction. Alternatively, after deadenylation, the mRNA body can be degraded by a minor pathway in the 3’-5’ direction. If many enzymes involved in mRNA decay are now known, some remain to be identified. Moreover, mechanisms activating specific enzymes in defined conditions need also to be elucidated. Finally, we are also interested in deciphering the coordination of mRNA decay with other cellular processes such as translation and in characterizing diseases resulting from alteration of this process.

Collaborations and networks

Bertrand Séraphin

  • Membre  de la RNA Society (USA) depuis 1995, membre élu de  son Conseil d'Administration (2006-2008)
  • Membre élu de l'EMBO (depuis 2000)

Eric Huntzinger

  • Comité d’organisation des Journées du Campus d’Illkirch

Funding and partners

In addition to those common to everyone in the institute:

  • Ligue Labellisée 2020
  • ANR

Awards and recognitions

B. Séraphin

  • Emilia Valori Prize, Académie des Sciences (2013)
  • European Inventor of the Year Nominee, European Patent Office (2008)
  • CNRS Silver Medal, CNRS (France) (2007)
  • Award of the International Society for Molecular Recognition, ISMR (2005)
  • 22nd William Ferdinand Memorial Lecture, University of Sheffield (2003)

News

Pho92 binds m6A residues to modulate messenger RNA levels and control meiotic recombination

The m6A residues, the most common internal modifications of eukaryotic messenger RNAs (mRNAs), contribute to various biological and pathological…

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Publications