Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management
3'-5' RNA decay and effects on pathologies
3'-5' RNA decay and effects on pathologies
SUBGROUP LEADER
While the main mRNA decay pathway involves the 5’ to 3’ degradation of the mRNA body, 3’ to 5’ exonucleolytic mRNA trimming has been shown to play a major role for the elimination of defective, poorly translatable transcripts. Factors involved in the latter pathway are altered in a rare human genetic disease, underlining its importance. In this context, we are testing the role of these factors in pathological conditions. Moreover, we have identified new factors associated with 3’-5’ mRNA decay and are actively pursuing their characterization.
Teams
Members
Researchers
Publications
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2023
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Chapter of the book
An RNA-ligation-based RACE-PAT assay to monitor poly(A) tail length of mRNAs of interest
- Fabienne Mauxion
- Bertrand Séraphin
Methods in Molecular Biology ; Page: 113-123
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Article in a journal
HELZ2: a new, interferon-regulated, human 3′-5′ exoribonuclease of the RNB family is expressed from a non-canonical initiation codon
- Eric Huntzinger
- Jordan Sinteff
- Bastien Morlet
- Bertrand Séraphin
Nucleic Acids Research
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Article in a journal
The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
- Fabienne Mauxion
- Jérôme Basquin
- Sevim Ozgur
- Marion Rame
- Jana Albrecht
- Ingmar Schäfer
- Bertrand Séraphin
- Elena Conti
Cell Reports ; Volume: 42 ; Page: 111902
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2022
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Article in a journal
The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts
- Jérémy Scutenaire
- Damien Plassard
- Mélody Matelot
- Tommaso Villa
- Julie Zumsteg
- Domenico Libri
- Bertrand Séraphin
Nucleic Acids Research
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2021
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Article in a journal
A conserved motif in human BTG1 and BTG2 proteins mediates interaction with the poly(A) binding protein PABPC1 to stimulate mRNA deadenylation
- Hamza Amine
- Nina Ripin
- Sahil Sharma
- Georg Stoecklin
- Frédéric Allain
- Bertrand Séraphin
- Fabienne Mauxion
RNA Biology ; Page: 1-16
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2020
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Article in a journal
Pby1 is a direct partner of the Dcp2 decapping enzyme
- Clément Charenton
- Claudine Gaudon-Plesse
- Régis Back
- Nathalie Ulryck
- Loreline Cosson
- Bertrand Séraphin
- Marc Graille
Nucleic Acids Research ; Volume: 48
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2019
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Article in a journal
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation
- Amy O'Connell
- Maxim Gerashchenko
- Marie-Françoise O'Donohue
- Samantha Rosen
- Eric Huntzinger
- Diane Gleeson
- Antonella Galli
- Edward Ryder
- Siqi Cao
- Quinn Murphy
- Shideh Kazerounian
- Sarah Morton
- Klaus Schmitz-Abe
- Vadim Gladyshev
- Pierre-Emmanuel Gleizes
- Bertrand Séraphin
- Pankaj Agrawal
PLoS Genetics ; Volume: 15 ; Page: e1007917
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2017
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Article in a journal
A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5′–3′ mRNA exonuclease in yeast
- Clément Charenton
- Claudine Gaudon-Plesse
- Zaineb Fourati
- Valério Taverniti
- Régis Back
- Olga Kolesnikova
- Bertrand Séraphin
- Marc Graille
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 114 ; Page: E9493-E9501
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Article in a journal
Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain
- A van Roon
- C Oubridge
- E Obayashi
- B Sposito
- A Newman
- Bertrand Séraphin
- K Nagai
RNA ; Volume: 23 ; Page: 968-981
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Article in a journal
Architecture of the yeast elongator complex
- M Dauden
- J Kosinski
- Olga Kolaj-Robin
- A Desfosses
- A Ori
- C Faux
- N Hoffmann
- O Onuma
- K Breunig
- M Beck
- C Sachse
- Bertrand Séraphin
- S Glatt
- C Muller
EMBO Reports ; Volume: 18 ; Page: 264-279
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