Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management
SUBGROUP LEADER
While the main mRNA decay pathway involves the 5’ to 3’ degradation of the mRNA body, 3’ to 5’ exonucleolytic mRNA trimming has been shown to play a major role for the elimination of defective, poorly translatable transcripts. Factors involved in the latter pathway are altered in a rare human genetic disease, underlining its importance. In this context, we are testing the role of these factors in pathological conditions. Moreover, we have identified new factors associated with 3’-5’ mRNA decay and are actively pursuing their characterization.
Methods in Molecular Biology ; Page: 113-123
Nucleic Acids Research
Cell Reports ; Volume: 42 ; Page: 111902
Nucleic Acids Research
RNA Biology ; Page: 1-16
Nucleic Acids Research ; Volume: 48
PLoS Genetics ; Volume: 15 ; Page: e1007917
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 114 ; Page: E9493-E9501
RNA ; Volume: 23 ; Page: 968-981