Molecular Basis of Chromatin and Transcription Regulation
Team Leader : Christophe ROMIER
Department : Integrated structural biology
Molecular mechanisms of chromatin reorganization
Molecular mechanisms of chromatin reorganization
Teams
Members
Researchers
Publications
2017
Article in a journal
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity
- Tino Heimburg
- Fiona Kolbinger
- Patrik Zeyen
- Ehab Ghazy
- Daniel Herp
- Karin Schmidtkunz
- Jelena Melesina
- Tajith Baba Shaik
- Frank Erdmann
- Matthias Schmidt
- Christophe Romier
- Dina Robaa
- Olaf Witt
- Ina Oehme
- Manfred Jung
- Wolfgang Sippl
Journal of Medicinal Chemistry ; Volume: 60 ; Page: 10188-10204
Article in a journal
Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni
- Katharina Stenzel
- Alokta Chakrabarti
- Jelena Melesina
- Finn Hansen
- Julien Lancelot
- Simon Herkenhohner
- Beate Lungerich
- Martin Marek
- Christophe Romier
- Raymond Pierce
- Wolfgang Sippl
- Manfred Jung
- T Kurz
Arch Pharm (Weinheim) ; Volume: 350
Article in a journal
Alkoxyurea-based histone deacetylase inhibitors increase cisplatin potency in chemoresistant cancer cell lines
- Katharina Stenzel
- Alexandra Hamacher
- Finn Hansen
- Christoph Gertzen
- Johanna Senger
- Viktoria Marquardt
- Linda Marek
- Martin Marek
- Christophe Romier
- Marc Remke
- Manfred Jung
- Holger Gohlke
- Matthias Kassack
- Thomas Kurz
Journal of Medicinal Chemistry ; Volume: 60 ; Page: 5334-5348
Article in a journal
Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni
- Leticia Anderson
- Monete Gomes
- Lucas Dasilva
- Adriana da Silva Andrade Pereira
- Marina Mourão
- Christophe Romier
- Raymond Pierce
- Sergio Verjovski-Almeida
PLoS Neglected Tropical Diseases ; Volume: 11
Article in a journal
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups
- Viktoria Krieger
- Alexandra Hamacher
- Christoph Gertzen
- Johanna Senger
- Martijn Zwinderman
- Martin Marek
- Christophe Romier
- Frank Dekker
- Thomas Kurz
- Manfred Jung
- Holger Gohlke
- Matthias Kassack
- Finn Hansen
Journal of Medical Chemistry ; Volume: 60 ; Page: 5493-5506
2016
Article in a journal
Molecular basis and specificity of H2A.Z–H2B recognition and deposition by the histone chaperone YL1
- Chrysa Latrick
- Martin Marek
- Khalid Ouararhni
- Christophe Papin
- Isabelle Stoll
- Maria Ignatyeva
- Arnaud Obri
- Eric Ennifar
- Stefan Dimitrov
- Christophe Romier
- Ali Hamiche
Nature Structural and Molecular Biology ; Volume: 23 ; Page: 309-316
Article in a journal
Structure-Based Design and Synthesis of Novel Inhibitors targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis
- Tino Heimburg
- Alokta Chakrabarti
- Julien Lancelot
- Martin Marek
- Jelena Melesina
- Alexander-Thomas Hauser
- Tajith B Shaik
- Sylvie Duclaud
- Dina Robaa
- Frank Erdmann
- Matthias Schmidt
- Christophe Romier
- Raymond J Pierce
- Manfred Jung
- Wolfgang Sippl
Journal of Medicinal Chemistry ; Volume: 59 ; Page: 2423-2435
Article in a journal
Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors
- J. Senger
- J. Melesina
- Martin Marek
- Christophe Romier
- I. Oehme
- O. Witt
- W. Sippl
- M. Jung
Journal of Medicinal Chemistry ; Volume: 59 ; Page: 1545-55
Article in a journal
Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni
- Martin Marek
- Tajith Baba Shaik
- Manfred Jung
- Wolfgang Sippl
- Raymond J. Pierce
- Christophe Romier
Biologie Aujourd'hui ; Volume: 210 ; Page: 311--320
Chapter of the book
Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput
- Renaud Vincentelli
- Christophe Romier
ADVANCED TECHNOLOGIES FOR PROTEIN COMPLEX PRODUCTION AND CHARACTERIZATION ; Volume: 896 ; Page: 43-58