XPD, at the crossroads of repair, transcription and mitosis
The XPD protein is known to be one of the subunits of TFIIH, a multiprotein complex involved in DNA repair and transcription of protein-coding genes. In this study published in the journal Science Advances, the researchers show that XPD can also play a role in chromosome segregation during mitosis, independently of its presence in TFIIH. Thus, this work highlights the multiple functions played by XPD and allows a better understanding of the etiology of diseases associated with it, such as Moon Child disease.
To learn more about this new publication by Emmanuel Compe and the Frédéric Coin and Izabela Sumara teams, you can read this article on the INSB website, or consult the publication directly.