
Genomeast
GenomEast
PLATFORM LEADER
With over 20 years of experience, we offer a wide range of services to explore genomes, their expression and regulation, from quality control of starting samples to data analysis. These services are intended for the entire scientific community, national and international, public and private.
The platform is a member of the central core of the France Genomics National Research Infrastructure
The platform is IBISA certified.
Currently equipped with an Illumina NextSeq 2000 sequencer, we are carrying out projects to analyse :
of the transcriptome :
- RNA-seq
- small RNA-seq
- Single cell RNA-seq (scRNA-seq)
of the epigenome :
- ChIP-seq
- Cut & Run
- MeDIP-seq
- We also have experience in sequencing your ATAC-seq or Cut & Tag libraries
of the genome :
- Targeted regions of the genome (exome, regions of interest)
- Full genome sequencing
For these projects, we prepare and sequence your libraries, performing quality controls at each step. We can also perform the bioinformatics analysis of your data. We have expertise in a wide variety of applications and have developed dedicated bioinformatics pipelines to analyze the corresponding results.
Alternatively, you can use our sequencing capabilityto sequence your own libraries as long as they are compatible with Illumina technology.
How to submit a project to GenomEast?
Via our web interface
All our services are governed by the general terms and conditions of sale, which take precedence over any conditions of purchase, unless otherwise agreed in writing by us.
We regularly share our knowledge and expertise through various courses and training sessions, including:
- The "High Throughput Approaches" course at the Ecole Supérieure de Biotechnologie de Strasbourg (ESBS)
- The "Omics 2" course of the Master 2 Biology-Health, Biomedicine Research course at the University of Strasbourg
- The PhD Program of the IMCBio University Research School in Strasbourg
- The DU "High-throughput sequencing and rare diseases" at the University of Dijon
- The AVIESAN IFB Inserm bioinformatics school
- The organisation of training courses in bioinformatics for high-throughput sequencing with Inserm and the CNRS
France Génomique
Our platform has been a partner of the France Genomics network since the initial selection of the project within the framework of the "Investissements d'avenir" in 2011. This network brings together and shares the resources of the main French genomics and bioinformatics platforms.
Fondation maladies rares
Since 2011, we have been one of the partner platforms of the Fondation maladies rares for the implementation of the "GenOmics: high throughput sequencing & rare diseases" programme, which aims to unravel the genetic and molecular basis of rare diseases using high throughput sequencing.
CORTECS
Starting 2021, we belong to the CORTECS network, which groups together the Scientific Research and Services Platforms of the University of Strasbourg in partnership with SATT Conectus Alsace and the services of the CNRS and INSERM.
New applications and technologies
Each year we evaluate new applications and technologies to enhance our service offering. We are currently testing 10X Genomics' ATAC-seq and multiome single cell solutions, we are also experimenting with alternative techniques to single cell droplet analysis and we are working on the implementation of 10X Genomics' Visium spatial transcriptomics technology.
Publications
2022
Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning
- Andrea Riba
- Attila Oravecz
- Matej Durik
- Sara Jiménez
- Violaine Alunni
- Marie Cerciat
- Matthieu Jung
- Céline Keime
- William Keyes
- Nacho Molina
Nature Communications ; Volume: 13 ; Page: 2865
Waves of sumoylation support transcription dynamics during adipocyte differentiation
- Xu Zhao
- Ivo A Hendriks
- Stéphanie Le Gras
- Tao Ye
- Lucía Ramos-Alonso
- Aurélie Nguéa P
- Guro Flor Lien
- Fatemeh Ghasemi
- Arne Klungland
- Bernard Jost
- Jorrit M Enserink
- Michael L Nielsen
- Pierre Chymkowitch
Nucleic Acids Research ; Volume: 50 ; Page: 1351-1369
2021
Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (2): impacts of post-partum negative energy balance on stromal, glandular and luminal epithelial cells
- Wiruntita Chankeaw
- Sandra Lignier
- Christophe Richard
- Theodoros Ntallaris
- Mariam Raliou
- Yongzhi Guo
- Damien Plassard
- Claudia Bevilacqua
- Olivier Sandra
- Göran Andersson
- Patrice Humblot
- Gilles Charpigny
BMC Genomics ; Volume: 22
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network
- Valérie Schreiber
- Reuben Mercier
- Sara Jiménez
- Tao Ye
- Emmanuel García-Sánchez
- Annabelle Klein
- Aline Meunier
- Sabitri Ghimire
- Catherine Birck
- Bernard Jost
- Kristian Honnens de Lichtenberg
- Christian Honoré
- Palle Serup
- Gérard Gradwohl
Molecular metabolism ; Volume: 53 ; Page: 101313
Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia
- Pasquale Pensieri
- Annabelle Mantilleri
- Damien Plassard
- Takahisa Furukawa
- Kenneth Moya
- Alain Prochiantz
- Thomas Lamonerie
eNeuro ; Volume: 8 ; Page: ENEURO.0229-21.2021
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells
- Giovanni Cova
- Chiara Taroni
- Marie-Céline Deau
- Qi Cai
- Vincent Mittelheisser
- Muriel Philipps
- Matthieu Jung
- Marie Cerciat
- Stéphanie Le Gras
- Christelle Thibault-Carpentier
- Bernard Jost
- Leif Carlsson
- Angela Thornton
- Ethan Shevach
- Peggy Kirstetter
- Philippe Kastner
- Susan Chan
Journal of Experimental Medicine ; Volume: 218
Ikaros deficiency is associated with aggressive BCR-ABL1 B cell precursor acute lymphoblastic leukemia independent of the lineage and developmental origin
- Célestine Simand
- Céline Keime
- Aurélie Caye
- Chloé Arfeuille
- Marie Passet
- Rathana Kim
- Helene Cavé
- Emmanuelle Clappier
- Philippe Kastner
- Susan Chan
- Beate Heizmann
Haematologica ; Volume: 107 ; Page: 316-320
Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer
- Aina Venkatasamy
- Eric Guerin
- Anais Blanchet
- Christophe Orvain
- Véronique Devignot
- Matthieu Jung
- Alain C. Jung
- Marie-Pierre Chenard
- Benoit Romain
- Christian Gaiddon
- Georg Mellitzer
MDPI AG ; Volume: 13 ; Page: 1485
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells
- Jiang Zhang
- Stéphanie Le Gras
- Kevin Pouxvielh
- Fabrice Faure
- Lucie Fallone
- Nicolas Kern
- Marion Moreews
- Anne-Laure Mathieu
- Raphaël Schneider
- Quentin Marliac
- Mathieu Jung
- Aurore Berton
- Simon Hayek
- Pierre-Olivier Vidalain
- Antoine Marçais
- Garvin Dodard
- Anne Dejean
- Laurent Brossay
- Yad Ghavi-Helm
- Thierry Walzer
Nature Communications ; Volume: 12 ; Page: 5446
CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma
- Pietro Berico
- Max Cigrang
- Guillaume Davidson
- Cathy Braun
- Jeremy Sandoz
- Stephanie Legras
- Bujamin Hektor Vokshi
- Nevena Slovic
- François Peyresaubes
- Carlos Mario Gene Robles
- Jean‐marc Egly
- Emmanuel Compe
- Irwin Davidson
- Frédéric Coin
EMBO Reports ; Volume: 22 ; Page: e51683