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Oncogenesis and progression of hormone-dependent cancers

Oncogenesis and progression of hormone-dependent cancers

SUBGROUP LEADER

Daniel METZGER

Estrogens and androgens stimulate the proliferation of epithelial cells of the breast and prostate, and contribute to the development of tumors. Breast and prostate cancers are the most common cancers in women and men, respectively, and are a major cause of death. Hormonal treatments based on anti-estrogens (e.g. Tamoxifen) and anti-androgens (e.g. flutamide, bicalutamide) are effective for some forms of these cancers, but also lead to resistance.
In order to study the molecular and cellular mechanisms underlying the initiation and progression of these cancers, we established mouse models reproducing the characteristics and kinetics of the human pathologies. This project aims to deconstruct the cellular complexity of their microenvironment, understand the molecular mechanisms of disease initiation and progression, as well as analyze the epigenetic signature and plasticity of tumor cells.

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Awards and recognitions

Daniel Metzger

  • Prix Marigny d'Alsace Contre le Cancer
  • Grand Prix René Turpin de Cancérologie / Fondation de l’Institut de France (2016)
  • Membre élu de l’EMBO (2013)
  • Membre élu de l’European Academy of Cancer Sciences (2012)
  • Médaille d’argent du CNRS (2010)
  • Grand Prix Jules Martin de l'Académie des Sciences (2007)
  • Prix Janine Courrier de l'Académie des Sciences (1999)

PhD students

  • Delphine DUTEIL - Prix de thèse - Conseil scientifique de l'Université de Strasbourg (2011)
  • Vanessa UEBERSCHLAG - Palmarès prix de thèse SBS : Prix de la Région du Grand Est - Société de Biologie de Strasbourg (2017)
  • Darya YANUSHKO - best Oral Presentation award at the Canceropole-Est Forum (2023)
  • Darya YANUSHKO - Poster prize at the 32nd journée scientifique de l'ARTP (2023)
  • Léa BOUHELIER - Poster prize at the 33rd journée scientifique de l'ARTP (2024)

News

Les Anges de Passage support breast cancer research

On Thursday, August 7, 2025, the association Les Anges de Passage, based in Lutterbach near Mulhouse, presented a check for €5,000 to Daniel Metzger’s…

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