Pathophysiological role of nuclear receptor signalling
Team Leader : Daniel METZGER
Department : Functional genomics and cancer
The active form of the hormone vitamin D controls calcium and phosphate levels in the body. In addition, it contributes to the regulation of the inflammation and cell proliferation, conferring a protective, even therapeutic, role in various cancers and autoimmune diseases.
To date, the mechanisms underlying the activities of vitamin D have not been elucidated. This lack of understanding limits its clinical use, since the doses required for the treatment of cancers or autoimmune diseases induce hypercalcemia; resulting in calcification of the kidneys, heart and vessels, leading to dysfunction of these organs.
Our group is interested in understanding how vitamin D controls calcium homeostasis and tumor progression. We focus on rare diseases characterized by impaired vitamin D signaling, and on prostate cancer.
We use patient cells and mouse models recapitulating human pathologies, and leverage single-cell and spatial transcriptomic analyses coupled with functional validations.
We also collaborate with chemists to characterise new vitamin D analogues with potent therapeutic activities for many diseases that are refractory to current treatments.
From 10 November to 10 December 2024, the Life PINK association is launching a fundraising campaign in Alsace, with the aim of raising €1 per…
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Gilles Laverny
Individual fellowship - Inserm (2021)
Poster prize - Fondation Maladies Rares (2019)
Trainee Award - Vitamin D workshop (2015)
Daniela Rovito
Young researcher award - OSCAR (2021)
Kateryna Len-Tayon
Trainee Award - Vitamin D workshop (2024).
Jury award - Fondation ARC (2024).
Poster prize - Association pour la Recherche sur les Tumeurs Prostatiques (2021)
PhD fellowship - Ministère de l'Education Nationale, de l'Enseignement supérieur et de la Recherche (2020)
Noe Pierrat
PhD fellowship - Fondation pour la Recherche Médicale (2023)
Vanessa Friedrich
PhD fellowship Inserm/Pfizer (2024)
Médecine/Sciences ; Volume: 41 ; Page: 154-159
British Journal of Pharmacology ; Page: Online ahead of print
Nature Communications ; Volume: 15 ; Page: 3563
International Journal of Molecular Sciences ; Volume: 25
Rheumatology
Biomolecules ; Volume: 14 ; Page: 551
International Journal of Molecular Sciences ; Volume: 24 ; Page: 5325
International Journal of Molecular Sciences ; Volume: 24 ; Page: 5325
International Journal of Molecular Sciences ; Volume: 23 ; Page: 8445
Science Advances ; Volume: 8 ; Page: eabo2295
Team Leader : Daniel METZGER
Department : Functional genomics and cancer