Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management
Translation/modification/RNA decay links
Translation/modification/RNA decay links
SUBGROUP LEADER
In eukaryotes, mRNA decay is intimately associated with translation. The latter process relies on specific marks to be efficient, namely the 5’ mRNA cap and the 3’ poly(A) tail. These characteristic modifications that delimits full mRNAs become ultimately the targets of the mRNA decay machinery. We are investigating how mRNA decay factors interact and/or interfere with the translation apparatus and how RNA modifications affect translation.
Teams
Members
Researchers
Publications
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2012
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Article in a journal
The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase
- S Glatt
- J Letoquart
- C Faux
- N Taylor
- Bertrand Séraphin
- C Muller
Nature Structural and Molecular Biology ; Volume: 19 ; Page: 314-320
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Article in a journal
Elongator: transcriptional or translational regulator?
- S Glatt
- Bertrand Séraphin
- C Muller
Transcription ; Volume: 3 ; Page: 273-276
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Article in a journal
Microbial proteomics: the quiet revolution
- Bertrand Séraphin
- R Hettich
Current Opinion in Microbiology ; Volume: 15 ; Page: 348-350
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Article in a journal
Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction
- J Basquin
- Vladimir Roudko
- M Rode
- C Basquin
- Bertrand Séraphin
- Eric Conti
Molecular Cell ; Volume: 48 ; Page: 207-218
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Article in a journal
Rbg1-Tma46 dimer structure reveals new functional domains and their role in polysome recruitment
- S Francis
- M Gas
- Marie-Claire Daugeron
- J Bravo
- Bertrand Séraphin
Nucleic Acids Research ; Volume: 40 ; Page: 11100-11114
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Article in a journal
Surveillance pathways rescuing eukaryotic ribosomes lost in translation
- Marc Graille
- Bertrand Séraphin
Nature Reviews Molecular Cell Biology ; Volume: 13 ; Page: 727-735
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2011
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Article in a journal
The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1
- Marie-Claire Daugeron
- Manoël Prouteau
- François Lacroute
- Bertrand Séraphin
Nucleic Acids Research ; Volume: 39 ; Page: 2221-2233
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Article in a journal
Cotranscriptional spliceosome assembly and splicing are independent of the Prp40p WW domain
- J Gornemann
- C Barrandon
- K Hujer
- B Rutz
- G Rigaut
- K Kotovic
- C Faux
- K Neugebauer
- Bertrand Séraphin
RNA ; Volume: 17 ; Page: 2119-2129
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Article in a journal
Catalytic properties of the eukaryotic exosome
- Aleksander Chlebowski
- María Eugenia Gas López
- Rafal Tomecki
- Bertrand Séraphin
- Andrzej Dziembowski
Advances in Experimental Medicine and Biology ; Volume: 702 ; Page: 63-78
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Article in a journal
Strategies for the structural analysis of multi-protein complexes: lessons from the 3D-Repertoire project
- B Collinet
- A Friberg
- M Brooks
- T van de Elzen
- V Henriot
- A Dziembowski
- M Graille
- D Durand
- N Leulliot
- C Saint Andre
- N Lazar
- M Sattler
- Bertrand Séraphin
- H van Tilbeurgh
Journal of Structural Biology ; Volume: 175 ; Page: 147-158
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