Pathophysiological role of nuclear receptor signalling
Team Leader : Daniel METZGER
Department : Functional genomics and cancer
Daniel METZGER
Researcher
metzger@igbmc.fr
Research team(s)
Research subgroup(s)
Publications
2007
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.
- Arup Kumar Indra
- Eduardo Castaneda
- Maria Cristina Antal
- Ming Jiang
- Nadia Messaddeq
- Xiangjun Meng
- Christiane V Loehr
- Patricio Gariglio
- Shigeaki Kato
- Walter Wahli
- Béatrice Desvergne
- Daniel Metzger
- Pierre Chambon
Journal of Investigative Dermatology ; Volume: 127 ; Page: 1250-60
Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.
- Daniel Metzger
- Pierre Chambon
Handb Exp Pharmacol ; Page: 511-24
Inducible Cre/loxP recombination in the mouse proximal tubule.
- Bernd Dworniczak
- Boris Skryabin
- Joëlle Tchinda
- Silke Heuck
- Franz-Josef Seesing
- Daniel Metzger
- Pierre Chambon
- Jürgen Horst
- Petra Pennekamp
Nephron Experimental Nephrology ; Volume: 106 ; Page: e11-20
2006
PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes.
- Michael Schuler
- Faisal Ali
- Céline Chambon
- Delphine Duteil
- Jean-Marc Bornert
- Aubry Tardivel
- Béatrice Desvergne
- Walter Wahli
- Pierre Chambon
- Daniel Metzger
Cell Metabolism ; Volume: 4 ; Page: 407-14
LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways.
- Xiaoren Tang
- Daniel Metzger
- Susan Leeman
- Salomon Amar
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 103 ; Page: 13777-82
Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.
- Thordur Oskarsson
- Marieke Alida Gertruda Essers
- Nicole Dubois
- Sandra Offner
- Christelle Dubey
- Catherine Roger
- Daniel Metzger
- Pierre Chambon
- Edith Hummler
- Peter Beard
- Andreas Trumpp
Genes and Development ; Volume: 20 ; Page: 2024-9
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.
- Mei Li
- Pierre Hener
- Zhikun Zhang
- Shigeaki Kato
- Daniel Metzger
- Pierre Chambon
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 103 ; Page: 11736-41
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
- Cécile Calléja
- Nadia Messaddeq
- Benoit Chapellier
- Haiyuan Yang
- Wojciech Krezel
- Mei Li
- Daniel Metzger
- Bénédicte Mascrez
- Kiminori Ohta
- Hiroyuki Kagechika
- Yasuyuki Endo
- Manuel Mark
- Norbert B Ghyselinck
- Pierre Chambon
Genes and Development ; Volume: 20 ; Page: 1525-38
Temporal regulation of Cre recombinase activity in neural stem cells.
- Itaru Imayoshi
- Toshiyuki Ohtsuka
- Daniel Metzger
- Pierre Chambon
- Ryoichiro Kageyama
Genesis ; Volume: 44 ; Page: 233-8
Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis.
- Athanasios Stratis
- Manolis Pasparakis
- Doreen Markur
- Renate Knaup
- Ruth Pofahl
- Daniel Metzger
- Pierre Chambon
- Thomas Krieg
- Ingo Haase
Journal of Investigative Dermatology ; Volume: 126 ; Page: 614-20