Congratulations to Roxane Benoit on the acceptance of her thesis!
Congratulations to Roxane Benoit for the acceptance of her thesis! Her work was directed by Anne-Cécile Reymann and titled: "Investigate actin content during C. elegans early embryogenesis using single cell extracts".
During her thesis, Roxane Benoit developed a process enabling simple and efficient extraction of single cell content from C. elegans embryos. Thanks to her research, it has been possible to quantify various parameters of actin dynamics, for example with F-actin. Present in variable amounts during early C. elegans development, the concentration of F-actin is maintained between sister cells. Roxane Benoit also demonstrated the variability of G-actin levels during development.
Want to know more about the technique developed by the PhD student? Applied to brain extracts, this technique was used to study the role of the Kif21b protein, in collaboration with Juliette Godin's team. To access the article published in Cell Reports: https://pubmed.ncbi.nlm.nih.gov/37418324/
During her time at the IGBMC, aside from developing her own technique to collect single-cell extract from C. elegans, Roxane Benoit mastered skills in microwells and micropatterns fabrication.
Roxane Benoit’s thesis was made possible through the support of our Imaging center (Erwan Grandigard, Elvire Guiot, Bertrand Vernay). The PhD student also worked with Laurent Blanchoin’s team (Christophe Guerin, Louise Bonnemay) from the CEA Grenoble/Paris and Gilles Charvin’s team from the GMGM to learn the microwells technique
Thanks to ARC Fundation for their support!
Roxane Benoit is now looking for her next opportunity as a postdoc in the study of the cytoskeleton, where she can best put in practice what she developed during her thesis with us! You can contact her if you wish to exchange more about her career plan.