OTX2 and EN1 homeoprotein transduction, from physiopathology to therapeutic strategies
Intercellular transfer has now been demonstrated for 150 homeoprotein transcription factors. However, the physiological functions served by this novel signaling pathways have only been studied for a handful of them, including OTX2 and ENGRAILED. The conference will focus on the role of OTX2 and ENGRAILED-1 signaling in the regulation of cerebral cortex plasticity and spinal cord a-Motoneuron physiology, respectively. The consequences of the latter recent findings in the development of original therapeutic strategies in mood disorders and Amyotrophic Lateral Sclerosis will be discussed.
Prof. Alain PROCHIANTZ
Center for Interdisciplinary Research in Biology
Collège de France