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Structure-function relationships of nuclear receptors and their co-regulators

Structure-function relationships of nuclear receptors and their co-regulators

SUBGROUP LEADER

Natacha ROCHEL-GUIBERTEAU

Nuclear receptors are ligand-regulated transcription factors that control nearly all aspects of human physiology. We are studying several members of the nuclear receptor family including the vitamin D receptor (VDR), peroxisome-activated receptors (PPARs) and retinoid receptors (RARs and RXRs). The objective of our research is to understand how the activation and repression of nuclear receptor transcription are regulated at the structural and molecular level using X-ray crystallography and other structural, biophysical and cellular methods.

 

Current projects

  • Structural studies of nuclear receptors-coregulators complexes
  • Mechanisms involved in the deregulation of nuclear receptor signaling
  • Structural pharmacology

Members

Researchers

PhD students

Engineers

Collaborations and networks

  • D. Metzger and G. Laverny (IGBMC)
  • A. Mourino (University Santiago de Compostella, Espagne)
  • I. Bernard-Pierrot and F. Radvanyi (Institut Curie, Paris)
  • G. Guichard (IECB Bordeaux)
  • V. Torbeev (ESBS, Strasbourg)
  • B. Kieffer and C. Deville (IGBMC)

Teams

Publications