Structure function of complexes involved in the HIV replication cycle, drug design

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Teams
Members
Publications

Structure function of complexes involved in the HIV replication cycle, drug design

SUBGROUP LEADER

Marc RUFF

Teams

Regulation of DNA topology
Team Leaders : Valerie LAMOUR , Marc RUFF
Department : Integrated structural biology

Members

Researchers

Engineers

Sylvia EILER

Technicians

Sylvie DUCLAUD

Publications

2018
- Article in a journal
  
  Genetic Flexibility of the NKNK Motif in HIV-1 Integrases Allows Its Involvement in Multiple Functions During Infection
  - Marine Kanja
  - Pierre Cappy
  - Guillermo Blanco-Rodriguez
  - Nicolas Levy
  - Sylvie Schmidt
  - Romain Gasser
  - Paola Rossolillo
  - Christiane Moog
  - M. Ruff
  - Francesca Di Nunzio
  - Matteo Negroni
  - Daniela Lener
  Synthetic Biology eJournal
  HAL DOI
- Article in a journal
  
  Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration
  - Damien Bonnard
  - Erwann Le Rouzic
  - Sylvia Eiler
  - Céline Amadori
  - Igor Orlov
  - Jean-Michel Bruneau
  - Julie Brias
  - Julien Barbion
  - Francis Chevreuil
  - Daniele Spehner
  - Sophie Chasset
  - Benoit Ledoussal
  - François Moreau
  - Ali Saib
  - Bruno P. Klaholz
  - Stéphane Emiliani
  - Marc Ruff
  - Alessia Zamborlini
  - Richard Benarous
  Journal of Biological Chemistry ; Volume: 293 ; Page: 6172-6186
  HAL DOI
- Chapter of the book
  
  Unstable Protein Purification Through the Formation of Stable Complexes
  - Sylvia Eiler
  - Nicolas Lévy
  - Benoit Maillot
  - Julien Batisse
  - Karine Pradeau Aubreton
  - Oyindamola Oladosu
  - Marc Ruff
  Methods in Molecular Biology ; Page: 315-328
  HAL DOI
- Article in a journal
  
  Toward High Resolution Structures of the HIV-1 In/LEDGF/DNA Complex
  - Julien Batisse
  - Eduardo Bruch
  - Nicolas Lévy
  - Benoit Maillot
  - Sylvia Eiler
  - Oyindamola Oladosu
  - Marc Ruff
  Biophysical Journal ; Volume: 114 ; Page: 218a
  HAL DOI
2017
- Article in a journal
  
  The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity
  - Céline Amadori
  - Yme Ubeles van Der Velden
  - Damien Bonnard
  - Igor Orlov
  - Nikki van Bel
  - Erwann Le Rouzic
  - Laia Miralles
  - Julie Brias
  - Francis Chevreuil
  - Daniele Spehner
  - Sophie Chasset
  - Benoit Ledoussal
  - Luzia Mayr
  - François Moreau
  - Felipe García
  - José Gatell
  - Alessia Zamborlini
  - Stéphane Emiliani
  - Marc Ruff
  - Bruno P. Klaholz
  - ...
  Retrovirology ; Volume: 14 ; Page: 50
  HAL DOI
- Article in a journal
  
  Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration
  - Julien Matysiak
  - Paul Lesbats
  - Eric Mauro
  - Delphine Lapaillerie
  - Jean-William Dupuy
  - Angelica P. Lopez
  - Mohamed Salah Benleulmi
  - Christina Calmels
  - Marie-Line Andreola
  - Marc Ruff
  - Manuel Llano
  - Olivier Delelis
  - Marc Lavigne
  - Vincent Parissi
  Retrovirology ; Volume: 14 ; Page: 39
  HAL DOI
- Article in a journal
  
  Dynamics of Methylated Cytosine Flipping by UHRF1
  - Christian Bronner
  - Vasyl Kilin
  - Krishna Gavvala
  - Nicolas Barthes
  - Benoît Michel
  - Dongwon Shin
  - Christian Boudier
  - Olivier Mauffret
  - Valeriy Yashchuk
  - Marc Mousli
  - Marc Ruff
  - Florence Granger
  - Sylvia Eiler
  - Yitzhak Tor
  - Alain Burger
  - Yves Mély
  Journal of the American Chemical Society ; Volume: 139 ; Page: 2520-2528
  HAL DOI
- Article in a journal
  
  The HIV-1 Pre-Integration Complexes: Structures, Functions and Dynamics
  - Nicolas Levy
  - Karine Pradeau-Aubreton
  - Sylvia Eiler
  - Julien Batisse
  - Oyindamola Oladosu
  - Benoit Maillot
  - Marc Ruff
  Biophysical Journal ; Volume: 112 ; Page: 30a
  HAL DOI
- Article in a journal
  
  Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails
  - Mohamed S Benleulmi
  - Julien Matysiak
  - Xavier Robert
  - Csaba Miskey
  - Eric Mauro
  - Delphine Lapaillerie
  - Paul Lesbats
  - Stéphane Chaignepain
  - Daniel R Henriquez
  - Christina Calmels
  - Oyindamola Oladosu
  - Eloïse Thierry
  - Oscar Leon
  - Marc Lavigne
  - Marie-Line Andreola
  - Olivier Delelis
  - Zoltán Ivics
  - Marc Ruff
  - Patrice Gouet
  - Vincent Parissi
  Retrovirology ; Volume: 14 ; Page: 54
  HAL DOI
2016
- Article in a journal
  
  DNA minicircles clarify the specific role of DNA structure on retroviral integration
  - Marc Pasi
  - Damien Mornico
  - Stevenn Volant
  - Anna Juchet
  - Julien Batisse
  - Christiane Bouchier
  - Vincent Parissi
  - Marc Ruff
  - Richard Lavery
  - Marc Lavigne
  Nucleic Acids Research ; Volume: 44 ; Page: 7830 - 7847
  HAL DOI