Molecular Basis of Chromatin and Transcription Regulation
Team Leader : Christophe ROMIER
Department : Integrated structural biology
Christophe ROMIER
Researcher
romier@igbmc.fr
Research team(s)
Research subgroup(s)
Publications
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2019
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Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors
- Katharina Vögerl
- Nghia Ong
- Johanna Senger
- Daniel Herp
- Karin Schmidtkunz
- Martin Marek
- Martin Müller
- Karin Bartel
- Tajith Shaik
- Nicholas Porter
- Dina Robaa
- David W. Christianson
- Christophe Romier
- Wolfgang Sippl
- Manfred Jung
- Franz Bracher
Journal of Medicinal Chemistry ; Volume: 62 ; Page: 1138-1166
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2018
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Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants
- Martin Marek
- Tajith Shaik
- Tino Heimburg
- Alokta Chakrabarti
- Julien Lancelot
- Elizabeth Ramos-Morales
- Cyrielle da Veiga
- Dmitrii Kalinin
- Jelena Melesina
- Dina Robaa
- Karin Schmidtkunz
- Takayoshi Suzuki
- Ralph Holl
- Eric Ennifar
- Raymond Pierce
- Manfred Jung
- Wolfang Sippl
- Christophe Romier
Journal of Medicinal Chemistry ; Volume: 61 ; Page: 10000-10016
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Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies
- Margherita Brindisi
- Johanna Senger
- Caterina Cavella
- Alessandro Grillo
- Giulia Chemi
- Sandra Gemma
- Dora Mariagrazia Cucinella
- Stefania Lamponi
- Federica Sarno
- Concetta Iside
- Angela Nebbioso
- Ettore Novellino
- Tajith Baba Shaik
- Christophe Romier
- Daniel Herp
- Manfred Jung
- Stefania Butini
- Giuseppe Campiani
- Lucia Altucci
- Simone Brogi
European Journal of Medicinal Chemistry ; Volume: 157 ; Page: 127-138
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Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity
- Bertrand Lecointre
- Remy Narozny
- Maria Teresa Borrello
- Johanna Senger
- Alokta Chakrabarti
- Manfred Jung
- Martin Marek
- Christophe Romier
- Jelena Melesina
- Wolfgang Sippl
- Laurent Bischoff
- A. Ganesan
Philosophical Transactions of the Royal Society B: Biological Sciences ; Volume: 373 ; Page: 20170364
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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing
- Conrad Simoben
- Dina Robaa
- Alokta Chakrabarti
- Karin Schmidtkunz
- Martin Marek
- Julien Lancelot
- Srinivasaraghavan Kannan
- Jelena Melesina
- Tajith Shaik
- Raymond J. Pierce
- Christophe Romier
- Manfred Jung
- Wolfgang Sippl
Molecules ; Volume: 23 ; Page: 566
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2017
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Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity
- Tino Heimburg
- Fiona Kolbinger
- Patrik Zeyen
- Ehab Ghazy
- Daniel Herp
- Karin Schmidtkunz
- Jelena Melesina
- Tajith Baba Shaik
- Frank Erdmann
- Matthias Schmidt
- Christophe Romier
- Dina Robaa
- Olaf Witt
- Ina Oehme
- Manfred Jung
- Wolfgang Sippl
Journal of Medicinal Chemistry ; Volume: 60 ; Page: 10188-10204
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Alkoxyurea-based histone deacetylase inhibitors increase cisplatin potency in chemoresistant cancer cell lines
- Katharina Stenzel
- Alexandra Hamacher
- Finn Hansen
- Christoph Gertzen
- Johanna Senger
- Viktoria Marquardt
- Linda Marek
- Martin Marek
- Christophe Romier
- Marc Remke
- Manfred Jung
- Holger Gohlke
- Matthias Kassack
- Thomas Kurz
Journal of Medicinal Chemistry ; Volume: 60 ; Page: 5334-5348
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Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni
- Katharina Stenzel
- Alokta Chakrabarti
- Jelena Melesina
- Finn Hansen
- Julien Lancelot
- Simon Herkenhohner
- Beate Lungerich
- Martin Marek
- Christophe Romier
- Raymond Pierce
- Wolfgang Sippl
- Manfred Jung
- T Kurz
Arch Pharm (Weinheim) ; Volume: 350
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Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni
- Leticia Anderson
- Monete Gomes
- Lucas Dasilva
- Adriana da Silva Andrade Pereira
- Marina Mourão
- Christophe Romier
- Raymond Pierce
- Sergio Verjovski-Almeida
PLoS Neglected Tropical Diseases ; Volume: 11
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Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups
- Viktoria Krieger
- Alexandra Hamacher
- Christoph Gertzen
- Johanna Senger
- Martijn Zwinderman
- Martin Marek
- Christophe Romier
- Frank Dekker
- Thomas Kurz
- Manfred Jung
- Holger Gohlke
- Matthias Kassack
- Finn Hansen
Journal of Medical Chemistry ; Volume: 60 ; Page: 5493-5506
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