Molecular Basis of Chromatin and Transcription Regulation
Team Leader : Christophe ROMIER
Department : Integrated structural biology
Christophe ROMIER
Researcher
romier@igbmc.fr
Research team(s)
Research subgroup(s)
Publications
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2025
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ADAT3 variants disrupt the activity of the ADAT tRNA deaminase complex and impair neuronal migration
- Jordi Del-Pozo-Rodriguez
- Peggy Tilly
- Romain Lecat
- Hugo Rolando Vaca
- Laureline Mosser
- Elena Brivio
- Till Balla
- Marina Vitoria Gomes
- Elizabeth Ramos-Morales
- Noémie Schwaller
- Thalia Salinas-Giegé
- Grace Vannoy
- Eleina England
- Alysia Kern Lovgren
- Melanie O’leary
- Maya Chopra
- Naomi Meave Ojeda
- Mehran Beiraghi Toosi
- Atieh Eslahi
- Masoome Alerasool
- ...
Brain - A Journal of Neurology
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2024
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The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains
- Marina Vitoria Gomes
- Pauline Landwerlin
- Marie-Laure Diebold-Durand
- Tajith B Shaik
- Alexandre Durand
- Edouard Troesch
- Chantal Weber
- Karl Brillet
- Marianne V Lemée
- Christophe Decroos
- Ludivine Dulac
- Pierre Antony
- Erwan Watrin
- Eric Ennifar
- Christelle Golzio
- Christophe Romier
Cell Reports ; Volume: 43 ; Page: 114656
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Structure–Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2
- Arianna Colcerasa
- Florian Friedrich
- Jelena Melesina
- Patrick Moser
- Anja Vogelmann
- Pavlos Tzortzoglou
- Emilia Neuwirt
- Manuela Sum
- Dina Robaa
- Lin Zhang
- Elizabeth Ramos-Morales
- Christophe Romier
- Oliver Einsle
- Eric Metzger
- Roland Schüle
- Olaf Groß
- Wolfgang Sippl
- Manfred Jung
Journal of Medicinal Chemistry ; Volume: 67 ; Page: 10076-10095
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2023
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Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation
- Laura Sinatra
- Anja Vogelmann
- Florian Friedrich
- Margarita A. Tararina
- Emilia Neuwirt
- Arianna Colcerasa
- Philipp König
- Lara Toy
- Talha Z. Yesiloglu
- Sebastian Hilscher
- Lena Gaitzsch
- Niklas Papenkordt
- Shiyang Zhai
- Lin Zhang
- Christophe Romier
- Oliver Einsle
- Wolfgang Sippl
- Mike Schutkowski
- Olaf Gross
- Gerd Bendas
- ...
Journal of Medicinal Chemistry ; Volume: 66 ; Page: 14787-14814
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Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras
- Salma Darwish
- Tino Heimburg
- Johannes Ridinger
- Daniel Herp
- Matthias Schmidt
- Christophe Romier
- Manfred Jung
- Ina Oehme
- Wolfgang Sippl
HDAC/HAT Function Assessment and Inhibitor Development ; Volume: 2589 ; Page: 179-193
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Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages
- Beatrice Noce
- Elisabetta Di Bello
- Clemens Zwergel
- Rossella Fioravanti
- Sergio Valente
- Dante Rotili
- Andrea Masotti
- Mohammad Salik Zeya Ansari
- Daniela Trisciuoglio
- Alokta Chakrabarti
- Christophe Romier
- Dina Robaa
- Wolfgang Sippl
- Manfred Jung
- Cécile Häberli
- Jennifer Keiser
- Antonello Mai
ChemMedChem ; Volume: 18
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In cellulo and in vivo assays for compound testing against Trypanosoma cruzi
- Eloise Pavão Guerra-Slompo
- Gisele Fernanda Assine Picchi-Constante
- Martin Marek
- Christophe Romier
- Wolfgang Sippl
- Nilson Ivo Tonin Zanchin
STAR Protocols ; Volume: 4 ; Page: 102058
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2022
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Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties
- Ping Sun
- Jing Wang
- Khadija S. Khan
- Weiqin Yang
- Billy Wai-Lung Ng
- Nikita Ilment
- Matthes Zessin
- Emre F. Bülbül
- Dina Robaa
- Frank Erdmann
- Matthias Schmidt
- Christophe Romier
- Mike Schutkowski
- Alfred Sze-Lok Cheng
- Wolfgang Sippl
Journal of Medicinal Chemistry ; Volume: 65 ; Page: 16313-16337
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Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni
- Muhammad Murtaza Hassan
- Abootaleb Sedighi
- Olasunkanmi O. Olaoye
- Cécile Häberli
- Annika Merz
- Elizabeth Ramos Morales
- Elvin D. de Araujo
- Christophe Romier
- Manfred Jung
- Jennifer Keiser
- Patrick T. Gunning
ChemMedChem ; Volume: 17
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First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement
- Daniel Herp
- Johannes Ridinger
- Dina Robaa
- Stephen A. Shinsky
- Karin Schmidtkunz
- Talha Z. Yesiloglu
- Theresa Bayer
- Raphael R. Steimbach
- Corey J. Herbst-Gervasoni
- Annika Merz
- Christophe Romier
- Peter Sehr
- Nikolas Gunkel
- Aubry K. Miller
- David W. Christianson
- Ina Oehme
- Wolfgang Sippl
- Manfred Jung
ChemBioChem ; Volume: 23
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