Postdoctoral position at the department of Integrative Structural Biology at the IGBMC in Strasbourg, France
Our group “Structure-function relationships of nuclear receptors and their co-regulators” (https://www.igbmc.fr/en/recherche/teams/subgroups/experimental-structure-function-studies-of-nuclear-receptor-and-coregulators) has an opening position for a 2-year postdoctoral research fellow funded by the French National Research Agency. We are looking for a highly motivated and self-organized postdoctoral fellow to investigate transcription coregulators.
Reference
Postdoctoral position at the department of Integrative Structural Biology
Contract type
POST-DOC
Publication date
04/16/2025
Environment:
Our institute is a leading research institute in Europe. The Integrated Structural Biology department integrates biochemical, biophysical, and structural approaches, to study increasing complex biological systems. The team will benefit of excellent in-house scientific services and technological platforms and to cutting-edge technological environment of the Centre for integrative biology (CBI). CBI houses world-class equipment and know-how in the fields of biological sample production and characterization, cryo-electron microscopy and super-resolution microscopy.
Selected references
- Perdriau C, Luton A, Zimmeter K, Neuville M, Saragaglia C, Peluso-Iltis C, Osz J, Kauffmann B, Collie GW, Rochel N, Guichard G, Pasco M. Guanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions. Angew Chem Int Ed Engl. 2025, 64(5), e202416348.
- Belorusova AY, Bourguet M, Hessmann S, Chalhoub S, Kieffer B, Cianferani S, Rochel N. Molecular determinant for MED1 interaction with the VDR-RXR heterodimer. Nucleic Acids Res. 2020, 48(19):11199-11213.
- Rochel N, Krucker C, Coutos-Thévenot L, Osz J, Zhang R, Guyon E, Zita W, Vanthong S, Hernandez OA, Bourguet M, Badawy KA, Dufour F, Peluso-Iltis C, Heckler-Beji S, Dejaegere A, Kamoun A, de Reyniès A, Neuzillet Y, Rebouissou S, Béraud C, Lang H, Massfelder T, Allory Y, Cianférani S, Stote RH, Radvanyi F, Bernard-Pierrot I. Recurrent activating mutations of PPARγ associated with luminal bladder tumors. Nat Commun. 2019, 10(1):253.
Application procedures
Application should be sent to Natacha Rochel (rochel@igbmc.fr). Interested candidates are invited to send a CV with skills and complete list of publications, a cover letter including a brief statement of research interests, past scientific experiences and achievements and the names and contact details for two references and recommendation letters.
Related to :
Missions
The project is centered on the understanding of the molecular mechanisms involving Mediator complex in transcription and transcription coupled repair and the consequences of identified pathogenic variants of Mediator subunits. This project developed in tight collaboration with expert biologists and clinicians aims to characterize Mediator complexes and consequences of the Mediator subunits variants as well as to identify proteins deregulated. The position requires the applicant to purify and reconstitute complexes for functional, biochemical and biophysical studies and for structural characterization by structural mass spectrometry and/or X-ray crystallography or cryo-electron microscopy.
Profil
Qualifications:
Applicants must hold a PhD in biological sciences (preferably in biochemistry or structural biology) and should have a strong background in biochemistry, purification of recombinantly expressed proteins and biophysics methods. Experience in structural mass spectrometry and/or cryo- electron microscopy would be a plus.