Chromatin and epigenetic regulation
Chromatin and epigenetic regulation
The main research activity of our group is to study the role of histone variants and their deposition machineries in the epigenetic control of human genome activity at the genome- wide level. Among the various epigenetic memory mechanisms, the local replacement of canonical histones within the nucleosome by variant histones has the potential to affect considerably the activity of the corresponding genomic regions. Indeed, nucleosomes bearing histone variants have distinct structures and functional activities in vitro and some histone variants are incorporated at specific genomic locations. Our laboratory is focusing on the role of histone variants in gene regulation and genome integrity. We have recently implicated macroH2A in PARP-1 enzymatic activity and transcription regulation (Ouararhni et al., 2006), and discovered a new link between histone variants, transcription factors and non- coding RNA (unpublished results). This association with transcription factors and non-coding RNA is novel and will certainly help us to understand how chromatin domains are established and how epigenetic information is stored and transmitted to daughter cells. Alteration of these epigenetic marks is associated with developmental disorders and cancer.
Members
Researchers
Post-doctoral fellows
PhD students
Engineers
Technicians
News
The quaternary structure of the GR highlights inter-domain allosteric communication
In inflammatory or autoimmune diseases, modulating the action of the glucocorticoid receptor (GR) is an effective therapeutic strategy. However, the…
Read more
Publications
-
2012
-
Cancer cell death and selection: Unexpected putative roles for pRb2/p130, BORIS and CTCF in endoplasmic stress response maintained by the T-antigen
- Christian Bronner
- Ali Hamiche
Cell Cycle ; Volume: 11 ; Page: 2052--2052
-
-
2011
-
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma
- Benjamin Herquel
- Khalid Ouararhni
- Konstantin Khetchoumian
- Mihaela Ignat
- Marius Teletin
- Manuel Mark
- Guillaume Béchade
- Alain van Dorsselaer
- Sarah Cianferani-Sanglier
- Ali Hamiche
- Florence Cammas
- Irwin Davidson
- Regine Losson
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 108 ; Page: 8212-8217
-
The docking domain of histone H2A is required for H1 binding and RSC-mediated nucleosome remodeling.
- Manu Shubhdarshan Shukla
- Sajad Hussain Syed
- Damien Goutte-Gattat
- John Lalith Charles Richard
- Fabien Montel
- Ali Hamiche
- Andrew Travers
- Cendrine Faivre-Moskalenko
- Jan Bednar
- Jeffrey J Hayes
- Dimitar Angelov
- Stefan Dimitrov
Nucleic Acids Research ; Volume: 39 ; Page: 2559-70
-
-
2010
-
The structural plasticity of SCA7 domains defines their differential nucleosome‐binding properties
- Jacques Bonnet
- Ying‐hui Wang
- Gianpiero Spedale
- R Andrew Atkinson
- Christophe Romier
- Ali Hamiche
- W Pijnappel
- H Th Marc Timmers
- László Tora
- Didier Devys
- Bruno Kieffer
EMBO Reports ; Volume: 11 ; Page: 612-618
-
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3
- Pascal Drané
- Khalid Ouararhni
- Arnaud Depaux
- Muhammad Shuaib
- Ali Hamiche
Genes and Development ; Volume: 24 ; Page: 1253-1265
-
HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres
- Muhammad Shuaib
- Khalid Ouararhni
- Stefan Dimitrov
- Ali Hamiche
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 107 ; Page: 1349-1354
-
-
1994
-
Octamer displacement and redistribution in transcription of single nucleosomes
- Marie-Françoise O'Donohue
- Isabelle Duband-Goulet
- Ali Hamiche
- Ariel Prunell
Nucleic Acids Research ; Volume: 22 ; Page: 937-945
-
Page 6 of 6